Whole-genome sequencing analyses suggest novel genetic factors associated with Alzheimer’s disease and a cumulative effects model for risk liability

Whole-genome sequencing analyses suggest novel genetic factors associated with Alzheimer’s disease and a cumulative effects model for risk liability

Abstract Genome-wide association studies (GWAS) on Alzheimer’s disease (AD) have predominantly focused on identifying common variants in Europeans. Here, we performed whole-genome sequencing (WGS) of 1,559 individuals from a Korean AD cohort to identify various genetic variants and biomarkers associ...

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Main Authors: Jun Pyo Kim, Minyoung Cho, Chanhee Kim, Hyunwoo Lee, Beomjin Jang, Sang-Hyuk Jung, Yujin Kim, In Gyeong Koh, Seoyeon Kim, Daeun Shin, Eun Hye Lee, Jong-Young Lee, YoungChan Park, Hyemin Jang, Bo-Hyun Kim, Hongki Ham, Beomsu Kim, A-Hyun Cho, Towfique Raj, Hee Jin Kim, Duk L. Na, Sang Won Seo, Joon-Yong An, Hong-Hee Won
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59949-y
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