Integrating Genomic Data Sets for Knowledge Discovery: An Informed Approach to Management of Captive Endangered Species
Many endangered captive populations exhibit reduced genetic diversity resulting in health issues that impact reproductive fitness and quality of life. Numerous cost effective genomic sequencing and genotyping technologies provide unparalleled opportunity for incorporating genomics knowledge in manag...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | International Journal of Genomics |
| Online Access: | http://dx.doi.org/10.1155/2016/2374610 |
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| author | Kristopher J. L. Irizarry Doug Bryant Jordan Kalish Curtis Eng Peggy L. Schmidt Gini Barrett Margaret C. Barr |
| author_facet | Kristopher J. L. Irizarry Doug Bryant Jordan Kalish Curtis Eng Peggy L. Schmidt Gini Barrett Margaret C. Barr |
| author_sort | Kristopher J. L. Irizarry |
| collection | DOAJ |
| description | Many endangered captive populations exhibit reduced genetic diversity resulting in health issues that impact reproductive fitness and quality of life. Numerous cost effective genomic sequencing and genotyping technologies provide unparalleled opportunity for incorporating genomics knowledge in management of endangered species. Genomic data, such as sequence data, transcriptome data, and genotyping data, provide critical information about a captive population that, when leveraged correctly, can be utilized to maximize population genetic variation while simultaneously reducing unintended introduction or propagation of undesirable phenotypes. Current approaches aimed at managing endangered captive populations utilize species survival plans (SSPs) that rely upon mean kinship estimates to maximize genetic diversity while simultaneously avoiding artificial selection in the breeding program. However, as genomic resources increase for each endangered species, the potential knowledge available for management also increases. Unlike model organisms in which considerable scientific resources are used to experimentally validate genotype-phenotype relationships, endangered species typically lack the necessary sample sizes and economic resources required for such studies. Even so, in the absence of experimentally verified genetic discoveries, genomics data still provides value. In fact, bioinformatics and comparative genomics approaches offer mechanisms for translating these raw genomics data sets into integrated knowledge that enable an informed approach to endangered species management. |
| format | Article |
| id | doaj-art-c63e6079380d42bdbf649b8b58226f42 |
| institution | Kabale University |
| issn | 2314-436X 2314-4378 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Genomics |
| spelling | doaj-art-c63e6079380d42bdbf649b8b58226f422025-02-03T01:10:49ZengWileyInternational Journal of Genomics2314-436X2314-43782016-01-01201610.1155/2016/23746102374610Integrating Genomic Data Sets for Knowledge Discovery: An Informed Approach to Management of Captive Endangered SpeciesKristopher J. L. Irizarry0Doug Bryant1Jordan Kalish2Curtis Eng3Peggy L. Schmidt4Gini Barrett5Margaret C. Barr6College of Veterinary Medicine, Western University of Health Sciences, 309 East Second Street, Pomona, CA 91766, USADanforth Center, 975 N. Warson Road, St. Louis, MO 63132, USACollege of Veterinary Medicine, Western University of Health Sciences, 309 East Second Street, Pomona, CA 91766, USACollege of Veterinary Medicine, Western University of Health Sciences, 309 East Second Street, Pomona, CA 91766, USACollege of Veterinary Medicine, Western University of Health Sciences, 309 East Second Street, Pomona, CA 91766, USACollege of Veterinary Medicine, Western University of Health Sciences, 309 East Second Street, Pomona, CA 91766, USACollege of Veterinary Medicine, Western University of Health Sciences, 309 East Second Street, Pomona, CA 91766, USAMany endangered captive populations exhibit reduced genetic diversity resulting in health issues that impact reproductive fitness and quality of life. Numerous cost effective genomic sequencing and genotyping technologies provide unparalleled opportunity for incorporating genomics knowledge in management of endangered species. Genomic data, such as sequence data, transcriptome data, and genotyping data, provide critical information about a captive population that, when leveraged correctly, can be utilized to maximize population genetic variation while simultaneously reducing unintended introduction or propagation of undesirable phenotypes. Current approaches aimed at managing endangered captive populations utilize species survival plans (SSPs) that rely upon mean kinship estimates to maximize genetic diversity while simultaneously avoiding artificial selection in the breeding program. However, as genomic resources increase for each endangered species, the potential knowledge available for management also increases. Unlike model organisms in which considerable scientific resources are used to experimentally validate genotype-phenotype relationships, endangered species typically lack the necessary sample sizes and economic resources required for such studies. Even so, in the absence of experimentally verified genetic discoveries, genomics data still provides value. In fact, bioinformatics and comparative genomics approaches offer mechanisms for translating these raw genomics data sets into integrated knowledge that enable an informed approach to endangered species management.http://dx.doi.org/10.1155/2016/2374610 |
| spellingShingle | Kristopher J. L. Irizarry Doug Bryant Jordan Kalish Curtis Eng Peggy L. Schmidt Gini Barrett Margaret C. Barr Integrating Genomic Data Sets for Knowledge Discovery: An Informed Approach to Management of Captive Endangered Species International Journal of Genomics |
| title | Integrating Genomic Data Sets for Knowledge Discovery: An Informed Approach to Management of Captive Endangered Species |
| title_full | Integrating Genomic Data Sets for Knowledge Discovery: An Informed Approach to Management of Captive Endangered Species |
| title_fullStr | Integrating Genomic Data Sets for Knowledge Discovery: An Informed Approach to Management of Captive Endangered Species |
| title_full_unstemmed | Integrating Genomic Data Sets for Knowledge Discovery: An Informed Approach to Management of Captive Endangered Species |
| title_short | Integrating Genomic Data Sets for Knowledge Discovery: An Informed Approach to Management of Captive Endangered Species |
| title_sort | integrating genomic data sets for knowledge discovery an informed approach to management of captive endangered species |
| url | http://dx.doi.org/10.1155/2016/2374610 |
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