Potential risk factors for diabetes mellitus type 1
Diabetes mellitus type 1 (T1D) develops as a result of the interaction of genetic and environmental factors. Genetic predisposition to T1D turns into clinical reality only in half of hereditary cases, which indirectly indicates the importance of external factors, the significance of which is periodi...
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2022-07-01
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| Series: | Сахарный диабет |
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| Online Access: | https://www.dia-endojournals.ru/jour/article/view/12573 |
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| author | K. G. Korneva L. G. Strongin K. Yu. Nazarova V. E. Zagainov |
| author_facet | K. G. Korneva L. G. Strongin K. Yu. Nazarova V. E. Zagainov |
| author_sort | K. G. Korneva |
| collection | DOAJ |
| description | Diabetes mellitus type 1 (T1D) develops as a result of the interaction of genetic and environmental factors. Genetic predisposition to T1D turns into clinical reality only in half of hereditary cases, which indirectly indicates the importance of external factors, the significance of which is periodically reviewed. Retrospective and prospective clinical foreign and national studies were included. PubMed, Medline and eLibrary were searched. Modern ideas about the possible impact of the main prenatal and postnatal environmental factors on the development of autoimmune response against insulin-producing islet cells and T1D were discussed. The risk of developing type 1 diabetes is determined by the complex interaction of environmental factors and genetic predisposition. The mechanisms of their influence remain rather unknown. Further research is needed to determine strategies of primary and secondary prevention of T1D. |
| format | Article |
| id | doaj-art-c63b5eac829c47d1b3c9da1464ec1f16 |
| institution | DOAJ |
| issn | 2072-0351 2072-0378 |
| language | English |
| publishDate | 2022-07-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj-art-c63b5eac829c47d1b3c9da1464ec1f162025-08-20T03:09:04ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782022-07-0125325626610.14341/DM1257310950Potential risk factors for diabetes mellitus type 1K. G. Korneva0L. G. Strongin1K. Yu. Nazarova2V. E. Zagainov3Privolzhsky Research Medical UniversityPrivolzhsky Research Medical UniversityPrivolzhsky Research Medical UniversityPrivolzhsky Research Medical UniversityDiabetes mellitus type 1 (T1D) develops as a result of the interaction of genetic and environmental factors. Genetic predisposition to T1D turns into clinical reality only in half of hereditary cases, which indirectly indicates the importance of external factors, the significance of which is periodically reviewed. Retrospective and prospective clinical foreign and national studies were included. PubMed, Medline and eLibrary were searched. Modern ideas about the possible impact of the main prenatal and postnatal environmental factors on the development of autoimmune response against insulin-producing islet cells and T1D were discussed. The risk of developing type 1 diabetes is determined by the complex interaction of environmental factors and genetic predisposition. The mechanisms of their influence remain rather unknown. Further research is needed to determine strategies of primary and secondary prevention of T1D.https://www.dia-endojournals.ru/jour/article/view/12573type 1 diabetes mellitus, risk factors, systematic review |
| spellingShingle | K. G. Korneva L. G. Strongin K. Yu. Nazarova V. E. Zagainov Potential risk factors for diabetes mellitus type 1 Сахарный диабет type 1 diabetes mellitus, risk factors, systematic review |
| title | Potential risk factors for diabetes mellitus type 1 |
| title_full | Potential risk factors for diabetes mellitus type 1 |
| title_fullStr | Potential risk factors for diabetes mellitus type 1 |
| title_full_unstemmed | Potential risk factors for diabetes mellitus type 1 |
| title_short | Potential risk factors for diabetes mellitus type 1 |
| title_sort | potential risk factors for diabetes mellitus type 1 |
| topic | type 1 diabetes mellitus, risk factors, systematic review |
| url | https://www.dia-endojournals.ru/jour/article/view/12573 |
| work_keys_str_mv | AT kgkorneva potentialriskfactorsfordiabetesmellitustype1 AT lgstrongin potentialriskfactorsfordiabetesmellitustype1 AT kyunazarova potentialriskfactorsfordiabetesmellitustype1 AT vezagainov potentialriskfactorsfordiabetesmellitustype1 |