Worsening of renal function in patients hospitalized with acutely decompensated heart failure
Background/Aim. A predictor of a poor prognosis, renal dysfunction often manifests in patients with heart failure, and is associated with an increased mortality in these patients. The aim of the parent study was to determine risk factors associated with worsening renal function (WRF) in patients hos...
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| Format: | Article |
| Language: | English |
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2018-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2018/0042-84501700038L.pdf |
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| author | Lazović Marko Radenković Sonja Stojanović Dijana Radović Jelena Stojanović Miodrag Tasić Danijela Stanojević Dragana |
| author_facet | Lazović Marko Radenković Sonja Stojanović Dijana Radović Jelena Stojanović Miodrag Tasić Danijela Stanojević Dragana |
| author_sort | Lazović Marko |
| collection | DOAJ |
| description | Background/Aim. A predictor of a poor prognosis, renal dysfunction often manifests in patients with heart failure, and is associated with an increased mortality in these patients. The aim of the parent study was to determine risk factors associated with worsening renal function (WRF) in patients hospitalized for acutely decompensated heart failure. Methods. The study included 330 patients with acutely decompensated heart failure. Patients who developed WRF (n = 215, mean age 72.4 ± 9.8 years) were in the clinical group, and patients without WRF (n = 115, mean age 59.8 ± 11.7 years) were in the control group. Patients in the clinical group were observed according to: the age, gender, lipids, electrolytes, smoking, hypertension, and type of heart failure, with reduced or preserved left ventricle ejection fraction (HFrEF or HFpEF). We used logistic regression to calculate non-adjusted odds ratio (OR) and 95% confidence intervals for occurrence of WRF. Results. WRF was determined in 65.2% of patients with heart failure. Non-adjusted OR showed that there was a significant risk for development of WRF with age (OR = 4.3; p < 0.01), total cholesterol > 5.2 mmol/L (OR = 1.6; p < 0.05), hyponatremia < 135 mmol/L, (OR = 2.8; p < 0.01), smoking (OR = 3.9; p < 0.01), hypertension (OR = 2.0; p < 0.05), and with the presence of HFrEF (OR = 1.3; p < 0.01). Presence of HFpEF, hypokalemia, < 3.5 mmol/L, plasma triglycerides, > 1.7 mmol/L, and gender, did not have any significance for the development of renal damage. Conclusion. Patients’ age, total cholesterol, hyponatremia, smoking, hypertension, and HFrEF were significant risk factors for worsening renal function in heart failure patients. Comparing predictive values, age could be the best prognostic tool for early identification of patients at risk for WRF. |
| format | Article |
| id | doaj-art-c63aa012fac346b997a4e6f44d8be2f2 |
| institution | OA Journals |
| issn | 0042-8450 2406-0720 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-c63aa012fac346b997a4e6f44d8be2f22025-08-20T02:02:37ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502406-07202018-01-0175111083108810.2298/VSP170226038L0042-84501700038LWorsening of renal function in patients hospitalized with acutely decompensated heart failureLazović Marko0Radenković Sonja1Stojanović Dijana2Radović Jelena3Stojanović Miodrag4Tasić Danijela5Stanojević Dragana6Clinical Center Niš, Clinic for Cardiology, Niš + Faculty of Medicine, Department of Internal Medicine, NišClinical Center Niš, Clinic for Nephrology Dialysis and Transplantation, Niš + Faculty of Medicine, Institute of Pathophysiology, NišFaculty of Medicine, Institute of Pathophysiology, NišFaculty of Medicine, Institute of Pathophysiology, NišInstitute for Public Health, NišClinical Center Niš, Clinic for Nephrology Dialysis and Transplantation, Niš Clinical Center Niš, Clinic for Cardiology, NišBackground/Aim. A predictor of a poor prognosis, renal dysfunction often manifests in patients with heart failure, and is associated with an increased mortality in these patients. The aim of the parent study was to determine risk factors associated with worsening renal function (WRF) in patients hospitalized for acutely decompensated heart failure. Methods. The study included 330 patients with acutely decompensated heart failure. Patients who developed WRF (n = 215, mean age 72.4 ± 9.8 years) were in the clinical group, and patients without WRF (n = 115, mean age 59.8 ± 11.7 years) were in the control group. Patients in the clinical group were observed according to: the age, gender, lipids, electrolytes, smoking, hypertension, and type of heart failure, with reduced or preserved left ventricle ejection fraction (HFrEF or HFpEF). We used logistic regression to calculate non-adjusted odds ratio (OR) and 95% confidence intervals for occurrence of WRF. Results. WRF was determined in 65.2% of patients with heart failure. Non-adjusted OR showed that there was a significant risk for development of WRF with age (OR = 4.3; p < 0.01), total cholesterol > 5.2 mmol/L (OR = 1.6; p < 0.05), hyponatremia < 135 mmol/L, (OR = 2.8; p < 0.01), smoking (OR = 3.9; p < 0.01), hypertension (OR = 2.0; p < 0.05), and with the presence of HFrEF (OR = 1.3; p < 0.01). Presence of HFpEF, hypokalemia, < 3.5 mmol/L, plasma triglycerides, > 1.7 mmol/L, and gender, did not have any significance for the development of renal damage. Conclusion. Patients’ age, total cholesterol, hyponatremia, smoking, hypertension, and HFrEF were significant risk factors for worsening renal function in heart failure patients. Comparing predictive values, age could be the best prognostic tool for early identification of patients at risk for WRF.http://www.doiserbia.nb.rs/img/doi/0042-8450/2018/0042-84501700038L.pdfheart failurecardio-renal syndromerisk factors |
| spellingShingle | Lazović Marko Radenković Sonja Stojanović Dijana Radović Jelena Stojanović Miodrag Tasić Danijela Stanojević Dragana Worsening of renal function in patients hospitalized with acutely decompensated heart failure Vojnosanitetski Pregled heart failure cardio-renal syndrome risk factors |
| title | Worsening of renal function in patients hospitalized with acutely decompensated heart failure |
| title_full | Worsening of renal function in patients hospitalized with acutely decompensated heart failure |
| title_fullStr | Worsening of renal function in patients hospitalized with acutely decompensated heart failure |
| title_full_unstemmed | Worsening of renal function in patients hospitalized with acutely decompensated heart failure |
| title_short | Worsening of renal function in patients hospitalized with acutely decompensated heart failure |
| title_sort | worsening of renal function in patients hospitalized with acutely decompensated heart failure |
| topic | heart failure cardio-renal syndrome risk factors |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2018/0042-84501700038L.pdf |
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