Effective anti-adhesives of uropathogenic Escherichia coli
Urinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC) are among the most common infectious diseases in humans. Due to their frequent occurrence in the community and nosocomial settings, as well as the development of resistance to the commonly prescribed antimicrobial agents...
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| Format: | Article |
| Language: | English |
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Sciendo
2018-03-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2018-0004 |
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| author | Ribić Rosana Meštrović Tomislav Neuberg Marijana Kozina Goran |
| author_facet | Ribić Rosana Meštrović Tomislav Neuberg Marijana Kozina Goran |
| author_sort | Ribić Rosana |
| collection | DOAJ |
| description | Urinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC) are among the most common infectious diseases in humans. Due to their frequent occurrence in the community and nosocomial settings, as well as the development of resistance to the commonly prescribed antimicrobial agents, an enormous financial burden is placed on healthcare systems around the world. Therefore, novel approaches to the prevention and treatment of UTIs are needed. Although UPEC may harbour a plethora of virulence factors, type I fimbriae and P pili are two of the most studied adhesive organelles, since the attachment to host cells in the urinary tract is a crucial step towards infection. Design of receptor analogues that competitively bind to UPEC surface adhesins placed at the top of pili organelles led to the development of anti-adhesive drugs that are increasingly recognized as important and promising alternatives to antibiotic treatment of UTIs. |
| format | Article |
| id | doaj-art-c61f8d7292ed49419212a26f121dc15e |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2018-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-c61f8d7292ed49419212a26f121dc15e2025-02-02T17:46:44ZengSciendoActa Pharmaceutica1846-95582018-03-0168111810.2478/acph-2018-0004acph-2018-0004Effective anti-adhesives of uropathogenic Escherichia coliRibić Rosana0Meštrović Tomislav1Neuberg Marijana2Kozina Goran3Research and Development Department, Tesla Ltd. 42244 Klenovnik, CroatiaClinical Microbiology and Parasitology Unit Polyclinic “Dr. Zora Profozić” 10000 Zagreb, CroatiaDepartment of Biomedical Sciences University Centre Varaždin University North, 42000 Varaždin, CroatiaDepartment of Biomedical Sciences University Centre Varaždin University North, 42000 Varaždin, CroatiaUrinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC) are among the most common infectious diseases in humans. Due to their frequent occurrence in the community and nosocomial settings, as well as the development of resistance to the commonly prescribed antimicrobial agents, an enormous financial burden is placed on healthcare systems around the world. Therefore, novel approaches to the prevention and treatment of UTIs are needed. Although UPEC may harbour a plethora of virulence factors, type I fimbriae and P pili are two of the most studied adhesive organelles, since the attachment to host cells in the urinary tract is a crucial step towards infection. Design of receptor analogues that competitively bind to UPEC surface adhesins placed at the top of pili organelles led to the development of anti-adhesive drugs that are increasingly recognized as important and promising alternatives to antibiotic treatment of UTIs.https://doi.org/10.2478/acph-2018-0004urinary tract infectionstype i fimbriaep pilimannosidescranberrypolyphenols |
| spellingShingle | Ribić Rosana Meštrović Tomislav Neuberg Marijana Kozina Goran Effective anti-adhesives of uropathogenic Escherichia coli Acta Pharmaceutica urinary tract infections type i fimbriae p pili mannosides cranberry polyphenols |
| title | Effective anti-adhesives of uropathogenic Escherichia coli |
| title_full | Effective anti-adhesives of uropathogenic Escherichia coli |
| title_fullStr | Effective anti-adhesives of uropathogenic Escherichia coli |
| title_full_unstemmed | Effective anti-adhesives of uropathogenic Escherichia coli |
| title_short | Effective anti-adhesives of uropathogenic Escherichia coli |
| title_sort | effective anti adhesives of uropathogenic escherichia coli |
| topic | urinary tract infections type i fimbriae p pili mannosides cranberry polyphenols |
| url | https://doi.org/10.2478/acph-2018-0004 |
| work_keys_str_mv | AT ribicrosana effectiveantiadhesivesofuropathogenicescherichiacoli AT mestrovictomislav effectiveantiadhesivesofuropathogenicescherichiacoli AT neubergmarijana effectiveantiadhesivesofuropathogenicescherichiacoli AT kozinagoran effectiveantiadhesivesofuropathogenicescherichiacoli |