Sustained release of miR-21 carried by mesenchymal stem cell-derived exosomes from GelMA microspheres inhibits ovarian granulosa cell apoptosis in premature ovarian insufficiency

Sustained release of miR-21 carried by mesenchymal stem cell-derived exosomes from GelMA microspheres inhibits ovarian granulosa cell apoptosis in premature ovarian insufficiency

Background: Premature ovarian insufficiency (POI) refers to the severe decline or failure of ovarian function in women younger than 40 years of age. It is a serious hazard to women's physical and mental health, but current treatment options are limited. Mesenchymal stem cell-derived exosomes (M...

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Bibliographic Details
Main Authors: Xiaofei Zhang, Linzi Ma, Xiaotong Liu, Xingyu Zhou, Ao Wang, Yunhui Lai, Jun Zhang, Ying Li, Shiling Chen
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Materials Today Bio
Subjects:
Exosomes
Mesenchymal stem cell
GelMA hydrogel
Ovarian granulosa cells
Premature ovarian insufficiency
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006425000274
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