Changes of Immunological Profiles in Patients with Chronic Myeloid Leukemia in the Course of Treatment
In the previous paper of ours we compared, prior to start any treatment, a number of immunological parameters in 24 chronic myeloid leukemia patients with the same number of healthy subjects matched by age and sex. We found significant differences in the levels of immunoglobulins, the C4 component o...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2010/137320 |
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| _version_ | 1832555131800911872 |
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| author | Zuzana Humlová Hana Klamová Ivana Janatková Karin Malícková Petra Králíková Ivan Šterzl Zdeněk Roth Eva Hamšíková Vladimír Vonka |
| author_facet | Zuzana Humlová Hana Klamová Ivana Janatková Karin Malícková Petra Králíková Ivan Šterzl Zdeněk Roth Eva Hamšíková Vladimír Vonka |
| author_sort | Zuzana Humlová |
| collection | DOAJ |
| description | In the previous paper of ours we compared, prior to start any treatment, a number of immunological parameters in 24 chronic myeloid leukemia patients with the same number of healthy subjects matched by age and sex. We found significant differences in the levels of immunoglobulins, the C4 component of complement, the C-reactive protein, interleukin 6, the composition of lymphocyte population and the production of some cytokines by stimulated CD3+ cells. Eleven of these patients were followed longitudinally. After treatment with hydroxyurea, interferon alpha, imatinib mesylate and dasatinib, or various combinations thereof, hematological remission was achieved in all patients and complete cytogenetic remission in nine of them. There was a nearly general tendency towards normalization of the abnormalities observed in the patients at their enrollment. |
| format | Article |
| id | doaj-art-c618fc624da74bea9a63dc767bf29762 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-c618fc624da74bea9a63dc767bf297622025-02-03T05:49:37ZengWileyClinical and Developmental Immunology1740-25221740-25302010-01-01201010.1155/2010/137320137320Changes of Immunological Profiles in Patients with Chronic Myeloid Leukemia in the Course of TreatmentZuzana Humlová0Hana Klamová1Ivana Janatková2Karin Malícková3Petra Králíková4Ivan Šterzl5Zdeněk Roth6Eva Hamšíková7Vladimír Vonka8Department of Immunology and Microbiology, 1st Medical Faculty, Charles University, and the General Teaching Hospital in Prague, Karlovo náměstí 32, 121 11 Prague 2, Czech RepublicClinical Department, Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20 Prague 2, Czech RepublicDepartment of Clinical Biochemistry and Laboratory Medicine, 1st Medical Faculty, Charles University, Karlovo náměstí 32, 121 11 Prague 2, Czech RepublicDepartment of Clinical Biochemistry and Laboratory Medicine, 1st Medical Faculty, Charles University, Karlovo náměstí 32, 121 11 Prague 2, Czech RepublicDepartment of Immunology, 2nd Medical Faculty, Charles University, V Úvalu 84, 150 06 Prague 5, Czech RepublicDepartment of Immunology and Microbiology, 1st Medical Faculty, Charles University, and the General Teaching Hospital in Prague, Karlovo náměstí 32, 121 11 Prague 2, Czech RepublicDepartment of Biostatistics, National Institute of Health, Šrobárova 48, 100 00 Prague 10, Czech RepublicDepartment of Experimental Virology, Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20 Prague 2, Czech RepublicDepartment of Experimental Virology, Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20 Prague 2, Czech RepublicIn the previous paper of ours we compared, prior to start any treatment, a number of immunological parameters in 24 chronic myeloid leukemia patients with the same number of healthy subjects matched by age and sex. We found significant differences in the levels of immunoglobulins, the C4 component of complement, the C-reactive protein, interleukin 6, the composition of lymphocyte population and the production of some cytokines by stimulated CD3+ cells. Eleven of these patients were followed longitudinally. After treatment with hydroxyurea, interferon alpha, imatinib mesylate and dasatinib, or various combinations thereof, hematological remission was achieved in all patients and complete cytogenetic remission in nine of them. There was a nearly general tendency towards normalization of the abnormalities observed in the patients at their enrollment.http://dx.doi.org/10.1155/2010/137320 |
| spellingShingle | Zuzana Humlová Hana Klamová Ivana Janatková Karin Malícková Petra Králíková Ivan Šterzl Zdeněk Roth Eva Hamšíková Vladimír Vonka Changes of Immunological Profiles in Patients with Chronic Myeloid Leukemia in the Course of Treatment Clinical and Developmental Immunology |
| title | Changes of Immunological Profiles in Patients with Chronic Myeloid Leukemia in the Course of Treatment |
| title_full | Changes of Immunological Profiles in Patients with Chronic Myeloid Leukemia in the Course of Treatment |
| title_fullStr | Changes of Immunological Profiles in Patients with Chronic Myeloid Leukemia in the Course of Treatment |
| title_full_unstemmed | Changes of Immunological Profiles in Patients with Chronic Myeloid Leukemia in the Course of Treatment |
| title_short | Changes of Immunological Profiles in Patients with Chronic Myeloid Leukemia in the Course of Treatment |
| title_sort | changes of immunological profiles in patients with chronic myeloid leukemia in the course of treatment |
| url | http://dx.doi.org/10.1155/2010/137320 |
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