Dexmedetomidine for delirium prevention in adult patients following cardiac surgery: a meta-analysis of randomized controlled trials
Abstract Objectives To determine whether perioperative administration of dexmedetomidine reduces the incidence of postoperative delirium in adult patients undergoing cardiac surgery. Methods We searched the PubMed, Embase and Cochrane Library databases for randomized controlled trials from the last...
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BMC
2025-01-01
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| Series: | Journal of Cardiothoracic Surgery |
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| Online Access: | https://doi.org/10.1186/s13019-025-03360-7 |
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| author | Chang Meng Duo Wang Yue Zhao Jing Sun Guobin Miao Lijuan Chen Ying Bai Peng Liu |
| author_facet | Chang Meng Duo Wang Yue Zhao Jing Sun Guobin Miao Lijuan Chen Ying Bai Peng Liu |
| author_sort | Chang Meng |
| collection | DOAJ |
| description | Abstract Objectives To determine whether perioperative administration of dexmedetomidine reduces the incidence of postoperative delirium in adult patients undergoing cardiac surgery. Methods We searched the PubMed, Embase and Cochrane Library databases for randomized controlled trials from the last 10 years up to March 10, 2024. We then conducted a meta-analysis to evaluate the effectiveness and safety of dexmedetomidine in preventing delirium after cardiac surgery in adults. This meta-analysis followed the steps in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA2020) guidelines. This study is registered with INPLASY under number INPLASY202430132. Results A total of 2689 patients were included in our analyses. All included studies were randomized controlled trials. Dexmedetomidine can reduce the occurrence of delirium in patients after cardiac surgery(OR 0.75, 95%CI 0.57–0.98, I2 = 12%, P = 0.04). In terms of other end events, length of intensive care unit(ICU) stay(MD -0.16, 95%CI -1.85-1.53, I2 = 0%, P = 0.85) and mortality(OR 1.59, 95%CI 0.74–3.42, I2 = 0%, P = 0.23) were not statistically different with dexmedetomidine compared with placebo. Bradycardia (OR 0.85, 95%CI 0.54 ~ 1.34, I2 = 72%, P = 0.49) and hypotension (OR 1.97, 95%CI 0.96 ~ 4.03, I2 = 84%, P = 0.06) were not significantly different between the two groups. Conclusions Dexmedetomidine is safe for cardiac surgery patients and to some extent reduces the incidence of delirium in cardiac surgery patients, which is more important in preoperative use. |
| format | Article |
| id | doaj-art-c60cf382cc974d3287b0a45ec77f0750 |
| institution | Kabale University |
| issn | 1749-8090 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Cardiothoracic Surgery |
| spelling | doaj-art-c60cf382cc974d3287b0a45ec77f07502025-02-02T12:42:04ZengBMCJournal of Cardiothoracic Surgery1749-80902025-01-012011810.1186/s13019-025-03360-7Dexmedetomidine for delirium prevention in adult patients following cardiac surgery: a meta-analysis of randomized controlled trialsChang Meng0Duo Wang1Yue Zhao2Jing Sun3Guobin Miao4Lijuan Chen5Ying Bai6Peng Liu7Department of Emergency, Emergency General HospitalDepartment of General Medicine, Ordos School of Clinical Medicine, Ordos Central Hospital, Inner Mongolia Medical UniversityDepartment of Emergency, Emergency General HospitalDepartment of Critical Care Medicine, Emergency General HospitalDepartment of Emergency, Emergency General HospitalDepartment of Emergency, Emergency General HospitalDepartment of Critical Care Medicine, Emergency General HospitalDepartment of Cardiology, Ordos School of Clinical Medicine, Ordos Central Hospital, Inner Mongolia Medical UniversityAbstract Objectives To determine whether perioperative administration of dexmedetomidine reduces the incidence of postoperative delirium in adult patients undergoing cardiac surgery. Methods We searched the PubMed, Embase and Cochrane Library databases for randomized controlled trials from the last 10 years up to March 10, 2024. We then conducted a meta-analysis to evaluate the effectiveness and safety of dexmedetomidine in preventing delirium after cardiac surgery in adults. This meta-analysis followed the steps in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA2020) guidelines. This study is registered with INPLASY under number INPLASY202430132. Results A total of 2689 patients were included in our analyses. All included studies were randomized controlled trials. Dexmedetomidine can reduce the occurrence of delirium in patients after cardiac surgery(OR 0.75, 95%CI 0.57–0.98, I2 = 12%, P = 0.04). In terms of other end events, length of intensive care unit(ICU) stay(MD -0.16, 95%CI -1.85-1.53, I2 = 0%, P = 0.85) and mortality(OR 1.59, 95%CI 0.74–3.42, I2 = 0%, P = 0.23) were not statistically different with dexmedetomidine compared with placebo. Bradycardia (OR 0.85, 95%CI 0.54 ~ 1.34, I2 = 72%, P = 0.49) and hypotension (OR 1.97, 95%CI 0.96 ~ 4.03, I2 = 84%, P = 0.06) were not significantly different between the two groups. Conclusions Dexmedetomidine is safe for cardiac surgery patients and to some extent reduces the incidence of delirium in cardiac surgery patients, which is more important in preoperative use.https://doi.org/10.1186/s13019-025-03360-7DexmedetomidineDeliriumCardiac surgery |
| spellingShingle | Chang Meng Duo Wang Yue Zhao Jing Sun Guobin Miao Lijuan Chen Ying Bai Peng Liu Dexmedetomidine for delirium prevention in adult patients following cardiac surgery: a meta-analysis of randomized controlled trials Journal of Cardiothoracic Surgery Dexmedetomidine Delirium Cardiac surgery |
| title | Dexmedetomidine for delirium prevention in adult patients following cardiac surgery: a meta-analysis of randomized controlled trials |
| title_full | Dexmedetomidine for delirium prevention in adult patients following cardiac surgery: a meta-analysis of randomized controlled trials |
| title_fullStr | Dexmedetomidine for delirium prevention in adult patients following cardiac surgery: a meta-analysis of randomized controlled trials |
| title_full_unstemmed | Dexmedetomidine for delirium prevention in adult patients following cardiac surgery: a meta-analysis of randomized controlled trials |
| title_short | Dexmedetomidine for delirium prevention in adult patients following cardiac surgery: a meta-analysis of randomized controlled trials |
| title_sort | dexmedetomidine for delirium prevention in adult patients following cardiac surgery a meta analysis of randomized controlled trials |
| topic | Dexmedetomidine Delirium Cardiac surgery |
| url | https://doi.org/10.1186/s13019-025-03360-7 |
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