Silver <i>N</i>-Heterocyclic Carbene (NHC) Complexes as Antimicrobial and/or Anticancer Agents
The strict connections/interactions between microbial infections and cancer are nowadays widely accepted. Hence, the dual (or multiple) targeting of microbial infections and cancer is an essential issue to be addressed. In this context, metal complexes have gained considerable importance and effecti...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-12-01
|
| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8247/18/1/9 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832587775618056192 |
|---|---|
| author | Jessica Ceramella Alessia Catalano Annaluisa Mariconda Assunta D’Amato Saveria Aquila Carmela Saturnino Camillo Rosano Maria Stefania Sinicropi Pasquale Longo |
| author_facet | Jessica Ceramella Alessia Catalano Annaluisa Mariconda Assunta D’Amato Saveria Aquila Carmela Saturnino Camillo Rosano Maria Stefania Sinicropi Pasquale Longo |
| author_sort | Jessica Ceramella |
| collection | DOAJ |
| description | The strict connections/interactions between microbial infections and cancer are nowadays widely accepted. Hence, the dual (or multiple) targeting of microbial infections and cancer is an essential issue to be addressed. In this context, metal complexes have gained considerable importance and effectiveness in medicinal chemistry. Particularly, <i>N</i>-heterocyclic carbene (NHC) complexes with transition metals have emerged as very promising compounds. Among the myriad of NHC–metal complexes, those bearing silver will be the subject of this review. Numerous Ag(I)-NHC complexes have revealed high antibacterial and/or anticancer properties, even higher than those of reference drugs. Herein, we summarize the most recent studies while also discussing the proposed mechanism of action and offering an interesting remark about the research in this field. Literature databases (PubMed/MEDLINE, Scopus, and Google Scholar) were used as sources to search the literature, referring to the last five years. |
| format | Article |
| id | doaj-art-c5f7fb8783164d629f4f99acc9069e15 |
| institution | Kabale University |
| issn | 1424-8247 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj-art-c5f7fb8783164d629f4f99acc9069e152025-01-24T13:44:58ZengMDPI AGPharmaceuticals1424-82472024-12-01181910.3390/ph18010009Silver <i>N</i>-Heterocyclic Carbene (NHC) Complexes as Antimicrobial and/or Anticancer AgentsJessica Ceramella0Alessia Catalano1Annaluisa Mariconda2Assunta D’Amato3Saveria Aquila4Carmela Saturnino5Camillo Rosano6Maria Stefania Sinicropi7Pasquale Longo8Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, via Pietro Bucci, 87036 Arcavacata di Rende, ItalyDepartment of Pharmacy-Drug Sciences, University of Bari “Aldo Moro”, Via Orabona, 4, 70126 Bari, ItalyDepartment of Basic and Applied Sciences, University of Basilicata, Via dell’Ateneo Lucano, 10, 85100 Potenza, ItalyDepartment of Chemistry and Biology “A. Zambelli”, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, ItalyDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, via Pietro Bucci, 87036 Arcavacata di Rende, ItalyDepartment of Health Sciences, University of Basilicata, Via dell’Ateneo Lucano, 10, 85100 Potenza, ItalyU.O. Proteomica e Spettrometria di Massa, IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi, 10, 16132 Genova, ItalyDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, via Pietro Bucci, 87036 Arcavacata di Rende, ItalyDepartment of Chemistry and Biology “A. Zambelli”, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, ItalyThe strict connections/interactions between microbial infections and cancer are nowadays widely accepted. Hence, the dual (or multiple) targeting of microbial infections and cancer is an essential issue to be addressed. In this context, metal complexes have gained considerable importance and effectiveness in medicinal chemistry. Particularly, <i>N</i>-heterocyclic carbene (NHC) complexes with transition metals have emerged as very promising compounds. Among the myriad of NHC–metal complexes, those bearing silver will be the subject of this review. Numerous Ag(I)-NHC complexes have revealed high antibacterial and/or anticancer properties, even higher than those of reference drugs. Herein, we summarize the most recent studies while also discussing the proposed mechanism of action and offering an interesting remark about the research in this field. Literature databases (PubMed/MEDLINE, Scopus, and Google Scholar) were used as sources to search the literature, referring to the last five years.https://www.mdpi.com/1424-8247/18/1/9SBC3silver–NHCAg(I)-NHCprecious metalslate-transition metalscatalysis |
| spellingShingle | Jessica Ceramella Alessia Catalano Annaluisa Mariconda Assunta D’Amato Saveria Aquila Carmela Saturnino Camillo Rosano Maria Stefania Sinicropi Pasquale Longo Silver <i>N</i>-Heterocyclic Carbene (NHC) Complexes as Antimicrobial and/or Anticancer Agents Pharmaceuticals SBC3 silver–NHC Ag(I)-NHC precious metals late-transition metals catalysis |
| title | Silver <i>N</i>-Heterocyclic Carbene (NHC) Complexes as Antimicrobial and/or Anticancer Agents |
| title_full | Silver <i>N</i>-Heterocyclic Carbene (NHC) Complexes as Antimicrobial and/or Anticancer Agents |
| title_fullStr | Silver <i>N</i>-Heterocyclic Carbene (NHC) Complexes as Antimicrobial and/or Anticancer Agents |
| title_full_unstemmed | Silver <i>N</i>-Heterocyclic Carbene (NHC) Complexes as Antimicrobial and/or Anticancer Agents |
| title_short | Silver <i>N</i>-Heterocyclic Carbene (NHC) Complexes as Antimicrobial and/or Anticancer Agents |
| title_sort | silver i n i heterocyclic carbene nhc complexes as antimicrobial and or anticancer agents |
| topic | SBC3 silver–NHC Ag(I)-NHC precious metals late-transition metals catalysis |
| url | https://www.mdpi.com/1424-8247/18/1/9 |
| work_keys_str_mv | AT jessicaceramella silveriniheterocycliccarbenenhccomplexesasantimicrobialandoranticanceragents AT alessiacatalano silveriniheterocycliccarbenenhccomplexesasantimicrobialandoranticanceragents AT annaluisamariconda silveriniheterocycliccarbenenhccomplexesasantimicrobialandoranticanceragents AT assuntadamato silveriniheterocycliccarbenenhccomplexesasantimicrobialandoranticanceragents AT saveriaaquila silveriniheterocycliccarbenenhccomplexesasantimicrobialandoranticanceragents AT carmelasaturnino silveriniheterocycliccarbenenhccomplexesasantimicrobialandoranticanceragents AT camillorosano silveriniheterocycliccarbenenhccomplexesasantimicrobialandoranticanceragents AT mariastefaniasinicropi silveriniheterocycliccarbenenhccomplexesasantimicrobialandoranticanceragents AT pasqualelongo silveriniheterocycliccarbenenhccomplexesasantimicrobialandoranticanceragents |