NON-ALCOHOLIC FATTY LIVER DISEASE AND CARDIOVASCULAR RISK: SCIENTIFIC PROBLEM STATE
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide, which is frequently present in patients with atherosclerosis or its complications (myocardial infarction, stroke). Subsequently it was revealed that NAFLD may increase cardiovascular risk independently of tradition...
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| Format: | Article |
| Language: | English |
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Столичная издательская компания
2017-11-01
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| Series: | Рациональная фармакотерапия в кардиологии |
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| Online Access: | https://www.rpcardio.online/jour/article/view/1533 |
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| _version_ | 1849227755497979904 |
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| author | O. M. Drapkina A. A. Yafarova |
| author_facet | O. M. Drapkina A. A. Yafarova |
| author_sort | O. M. Drapkina |
| collection | DOAJ |
| description | Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide, which is frequently present in patients with atherosclerosis or its complications (myocardial infarction, stroke). Subsequently it was revealed that NAFLD may increase cardiovascular risk independently of traditional cardiovascular risk factors. Possible mechanisms of NAFLD-induced increasing cardiovascular risk are increased oxidative stress, subclinical inflammation, insulin resistance, endothelial dysfunction and deranged аdipocytokines profile. Such risk factors as arterial hypertension, dyslipidemia, obesity, diabetes mellitus type 2 often coexist with NAFLD and contribute to increased cardiovascular risk in these patients. Thus, NAFLD can be considered as an additional risk factor of cardiovascular diseases. In this article we discuss in detail the NAFLD-induced mechanisms which increase the cardiovascular risk regardless of traditional risk factors. |
| format | Article |
| id | doaj-art-c5e6a8587b6c4781b3cc99129112cc47 |
| institution | Kabale University |
| issn | 1819-6446 2225-3653 |
| language | English |
| publishDate | 2017-11-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj-art-c5e6a8587b6c4781b3cc99129112cc472025-08-23T10:00:28ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532017-11-0113564565010.20996/1819-6446-2017-13-5-645-6501388NON-ALCOHOLIC FATTY LIVER DISEASE AND CARDIOVASCULAR RISK: SCIENTIFIC PROBLEM STATEO. M. Drapkina0A. A. Yafarova1National Medical Research Center for Preventive MedicineI.M. Sechenov First Moscow State Medical UniversityNon-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide, which is frequently present in patients with atherosclerosis or its complications (myocardial infarction, stroke). Subsequently it was revealed that NAFLD may increase cardiovascular risk independently of traditional cardiovascular risk factors. Possible mechanisms of NAFLD-induced increasing cardiovascular risk are increased oxidative stress, subclinical inflammation, insulin resistance, endothelial dysfunction and deranged аdipocytokines profile. Such risk factors as arterial hypertension, dyslipidemia, obesity, diabetes mellitus type 2 often coexist with NAFLD and contribute to increased cardiovascular risk in these patients. Thus, NAFLD can be considered as an additional risk factor of cardiovascular diseases. In this article we discuss in detail the NAFLD-induced mechanisms which increase the cardiovascular risk regardless of traditional risk factors.https://www.rpcardio.online/jour/article/view/1533non-alcoholic fatty liver diseaserisk factorsatherosclerosis |
| spellingShingle | O. M. Drapkina A. A. Yafarova NON-ALCOHOLIC FATTY LIVER DISEASE AND CARDIOVASCULAR RISK: SCIENTIFIC PROBLEM STATE Рациональная фармакотерапия в кардиологии non-alcoholic fatty liver disease risk factors atherosclerosis |
| title | NON-ALCOHOLIC FATTY LIVER DISEASE AND CARDIOVASCULAR RISK: SCIENTIFIC PROBLEM STATE |
| title_full | NON-ALCOHOLIC FATTY LIVER DISEASE AND CARDIOVASCULAR RISK: SCIENTIFIC PROBLEM STATE |
| title_fullStr | NON-ALCOHOLIC FATTY LIVER DISEASE AND CARDIOVASCULAR RISK: SCIENTIFIC PROBLEM STATE |
| title_full_unstemmed | NON-ALCOHOLIC FATTY LIVER DISEASE AND CARDIOVASCULAR RISK: SCIENTIFIC PROBLEM STATE |
| title_short | NON-ALCOHOLIC FATTY LIVER DISEASE AND CARDIOVASCULAR RISK: SCIENTIFIC PROBLEM STATE |
| title_sort | non alcoholic fatty liver disease and cardiovascular risk scientific problem state |
| topic | non-alcoholic fatty liver disease risk factors atherosclerosis |
| url | https://www.rpcardio.online/jour/article/view/1533 |
| work_keys_str_mv | AT omdrapkina nonalcoholicfattyliverdiseaseandcardiovascularriskscientificproblemstate AT aayafarova nonalcoholicfattyliverdiseaseandcardiovascularriskscientificproblemstate |