Meisoindigo Acts as a Molecular Glue to Target PKMYT1 for Degradation in Chronic Myeloid Leukemia Therapy

Meisoindigo Acts as a Molecular Glue to Target PKMYT1 for Degradation in Chronic Myeloid Leukemia Therapy

Abstract Meisoindigo (Mei) has been clinically utilized for the treatment of chronic myeloid leukemia (CML), yet the precise molecular targets by which it exerts effects remain unclear. Through activity‐based protein profiling (ABPP), the protein kinase, membrane‐associated tyrosine/threonine 1 (PKM...

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Main Authors:	Zhao‐Xin Zhang, Shu‐Ying Li, Fang‐Fei Li, Qin‐Yan Shi, Cheng‐Yong Tan, Xiao‐Jing Wang, Mi Li, Yun‐Bao Liu, Jing Jin, Yong Li, Shi‐Shan Yu
Format:	Article
Language:	English
Published:	Wiley 2025-06-01
Series:	Advanced Science
Subjects:	activity‐based protein profiling chronic myeloid leukemia E3 ligase TRIM25 molecular glue PKMYT1
Online Access:	https://doi.org/10.1002/advs.202413676
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