Unusual Presentation of Primary Sclerosing Cholangitis
A 23-year-old man presenting with acute pancreatitis and autoimmune hemolytic anemia was diagnosed with primary sclerosing cholangitis (PSC) without evidence of ulcerative colitis. This co...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
1997-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1997/948191 |
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| _version_ | 1832551976907309056 |
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| author | BC Pineau LP Pattee S McGuire A Sekar LJ Scully |
| author_facet | BC Pineau LP Pattee S McGuire A Sekar LJ Scully |
| author_sort | BC Pineau |
| collection | DOAJ |
| description | A 23-year-old man presenting with acute pancreatitis and autoimmune hemolytic anemia was diagnosed with primary sclerosing cholangitis (PSC) without evidence of ulcerative colitis. This constellation of rare associations constitutes a unique mode of presentation of PSC. Within two years he also developed ankylosing spondylitis with sacroiliitis. Disordered immune regulation as a major factor in the mechanism of injury in PSC is supported by its increased association with other immunologically mediated disorders, most notably ulcerative colitis. Autoimmune hemolytic anemia, however, has been reported to be associated with PSC on only two occasions, and ankylosing spondylitis in the absence of ulcerative colitis is also unusual. In addition, the presentation of PSC with acute pancreatitis has rarely been described. This patient presented with several unusual features of PSC. |
| format | Article |
| id | doaj-art-c5d75139a1cc44fab561f0309dfab479 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 1997-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-c5d75139a1cc44fab561f0309dfab4792025-02-03T06:00:02ZengWileyCanadian Journal of Gastroenterology0835-79001997-01-01111454810.1155/1997/948191Unusual Presentation of Primary Sclerosing CholangitisBC Pineau0LP Pattee1S McGuire2A Sekar3LJ Scully4Department of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, CanadaDepartment of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, CanadaDepartment of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, CanadaDepartment of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, CanadaDepartment of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, CanadaA 23-year-old man presenting with acute pancreatitis and autoimmune hemolytic anemia was diagnosed with primary sclerosing cholangitis (PSC) without evidence of ulcerative colitis. This constellation of rare associations constitutes a unique mode of presentation of PSC. Within two years he also developed ankylosing spondylitis with sacroiliitis. Disordered immune regulation as a major factor in the mechanism of injury in PSC is supported by its increased association with other immunologically mediated disorders, most notably ulcerative colitis. Autoimmune hemolytic anemia, however, has been reported to be associated with PSC on only two occasions, and ankylosing spondylitis in the absence of ulcerative colitis is also unusual. In addition, the presentation of PSC with acute pancreatitis has rarely been described. This patient presented with several unusual features of PSC.http://dx.doi.org/10.1155/1997/948191 |
| spellingShingle | BC Pineau LP Pattee S McGuire A Sekar LJ Scully Unusual Presentation of Primary Sclerosing Cholangitis Canadian Journal of Gastroenterology |
| title | Unusual Presentation of Primary Sclerosing Cholangitis |
| title_full | Unusual Presentation of Primary Sclerosing Cholangitis |
| title_fullStr | Unusual Presentation of Primary Sclerosing Cholangitis |
| title_full_unstemmed | Unusual Presentation of Primary Sclerosing Cholangitis |
| title_short | Unusual Presentation of Primary Sclerosing Cholangitis |
| title_sort | unusual presentation of primary sclerosing cholangitis |
| url | http://dx.doi.org/10.1155/1997/948191 |
| work_keys_str_mv | AT bcpineau unusualpresentationofprimarysclerosingcholangitis AT lppattee unusualpresentationofprimarysclerosingcholangitis AT smcguire unusualpresentationofprimarysclerosingcholangitis AT asekar unusualpresentationofprimarysclerosingcholangitis AT ljscully unusualpresentationofprimarysclerosingcholangitis |