Epstein-Barr virus (EBV) DNAemia in saliva of viral encephalitis and nasopharyngeal carcinoma patients
Epstein-Barr virus (EBV) is a lymphotropic virus that causes diseases ranging from a flu-like illness called infectious mononucleosis to nasopharyngeal carcinoma, Burkitt’s lymphoma, and central nervous system (CNS) infection. Detection of EBV DNA is usually done using whole blood samples taken from...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-01-01
|
| Series: | Indian Journal of Pathology and Microbiology |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/ijpm.ijpm_356_23 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850185647490334720 |
|---|---|
| author | Nanditha Srinivasan Ramya Barani M Manickavasagan Padma Srikanth |
| author_facet | Nanditha Srinivasan Ramya Barani M Manickavasagan Padma Srikanth |
| author_sort | Nanditha Srinivasan |
| collection | DOAJ |
| description | Epstein-Barr virus (EBV) is a lymphotropic virus that causes diseases ranging from a flu-like illness called infectious mononucleosis to nasopharyngeal carcinoma, Burkitt’s lymphoma, and central nervous system (CNS) infection. Detection of EBV DNA is usually done using whole blood samples taken from the patients. We undertook the detection of EBV in blood, cerebrospinal fluid (CSF), and saliva by real-time quantitative PCR in two patients, one with a history of nasopharyngeal carcinoma, and the other having a case of viral encephalitis. EBV was detected only in saliva, whole blood in both patients, and CSF in the second case tested negative. This case series illustrates the importance of testing for EBV DNAemia in saliva by real-time polymerase chain reaction (PCR) to rule in a diagnosis of EBV. |
| format | Article |
| id | doaj-art-c5d1b5bb917c47ff894a6da9afbc5d30 |
| institution | OA Journals |
| issn | 0377-4929 0974-5130 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj-art-c5d1b5bb917c47ff894a6da9afbc5d302025-08-20T02:16:39ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49290974-51302025-01-0168120821110.4103/ijpm.ijpm_356_23Epstein-Barr virus (EBV) DNAemia in saliva of viral encephalitis and nasopharyngeal carcinoma patientsNanditha SrinivasanRamya BaraniM ManickavasaganPadma SrikanthEpstein-Barr virus (EBV) is a lymphotropic virus that causes diseases ranging from a flu-like illness called infectious mononucleosis to nasopharyngeal carcinoma, Burkitt’s lymphoma, and central nervous system (CNS) infection. Detection of EBV DNA is usually done using whole blood samples taken from the patients. We undertook the detection of EBV in blood, cerebrospinal fluid (CSF), and saliva by real-time quantitative PCR in two patients, one with a history of nasopharyngeal carcinoma, and the other having a case of viral encephalitis. EBV was detected only in saliva, whole blood in both patients, and CSF in the second case tested negative. This case series illustrates the importance of testing for EBV DNAemia in saliva by real-time polymerase chain reaction (PCR) to rule in a diagnosis of EBV.https://journals.lww.com/10.4103/ijpm.ijpm_356_23clinical awarenessepstein-barr virusreal-time quantitative pcrsaliva |
| spellingShingle | Nanditha Srinivasan Ramya Barani M Manickavasagan Padma Srikanth Epstein-Barr virus (EBV) DNAemia in saliva of viral encephalitis and nasopharyngeal carcinoma patients Indian Journal of Pathology and Microbiology clinical awareness epstein-barr virus real-time quantitative pcr saliva |
| title | Epstein-Barr virus (EBV) DNAemia in saliva of viral encephalitis and nasopharyngeal carcinoma patients |
| title_full | Epstein-Barr virus (EBV) DNAemia in saliva of viral encephalitis and nasopharyngeal carcinoma patients |
| title_fullStr | Epstein-Barr virus (EBV) DNAemia in saliva of viral encephalitis and nasopharyngeal carcinoma patients |
| title_full_unstemmed | Epstein-Barr virus (EBV) DNAemia in saliva of viral encephalitis and nasopharyngeal carcinoma patients |
| title_short | Epstein-Barr virus (EBV) DNAemia in saliva of viral encephalitis and nasopharyngeal carcinoma patients |
| title_sort | epstein barr virus ebv dnaemia in saliva of viral encephalitis and nasopharyngeal carcinoma patients |
| topic | clinical awareness epstein-barr virus real-time quantitative pcr saliva |
| url | https://journals.lww.com/10.4103/ijpm.ijpm_356_23 |
| work_keys_str_mv | AT nandithasrinivasan epsteinbarrvirusebvdnaemiainsalivaofviralencephalitisandnasopharyngealcarcinomapatients AT ramyabarani epsteinbarrvirusebvdnaemiainsalivaofviralencephalitisandnasopharyngealcarcinomapatients AT mmanickavasagan epsteinbarrvirusebvdnaemiainsalivaofviralencephalitisandnasopharyngealcarcinomapatients AT padmasrikanth epsteinbarrvirusebvdnaemiainsalivaofviralencephalitisandnasopharyngealcarcinomapatients |