Quantitative Assessment of Deep Gray Matter Susceptibility and Correlation With Cognition in Patients With Liver Cirrhosis
ABSTRACT Background and Objectives Accumulation of metals quantified by quantitative susceptibility mapping (QSM) in deep gray matter (DGM) and their impact on cognition have not been studied in patients with liver cirrhosis. This study aims to use QSM to investigate the association between DGM susc...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
|
| Series: | Brain and Behavior |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/brb3.70240 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832582653564420096 |
|---|---|
| author | Wenjun Wu Yu Su Ziji Qin Jiamin Kang Dongqiao Xiang Dingxi Liu Chuansheng Zheng E. Mark Haacke Lixia Wang |
| author_facet | Wenjun Wu Yu Su Ziji Qin Jiamin Kang Dongqiao Xiang Dingxi Liu Chuansheng Zheng E. Mark Haacke Lixia Wang |
| author_sort | Wenjun Wu |
| collection | DOAJ |
| description | ABSTRACT Background and Objectives Accumulation of metals quantified by quantitative susceptibility mapping (QSM) in deep gray matter (DGM) and their impact on cognition have not been studied in patients with liver cirrhosis. This study aims to use QSM to investigate the association between DGM susceptibility and cognition in cirrhotic patients. Methods Thirty cirrhotic patients and 30 age‐, gender‐, and education‐matched controls were imaged using a multiecho gradient‐echo sequence for QSM analysis in a 3T scanner. The susceptibility values were determined for the caudate nucleus (CN), putamen (PU), globus pallidus (GP), thalamus (TH), red nucleus (RN), substantia nigra (SN), and dentate nucleus (DN). All subjects underwent number connection test A (NCT‐A), digit substitution test (DST), and Montreal Cognitive Assessment (MoCA). Comparisons between the two groups and the correlation between the susceptibility values and neuropsychological scores were analyzed. Results The susceptibility values of bilateral CN, TH, and RN were significantly lower in cirrhotic patients. Cirrhotic patients exhibited significantly prolonged NCT‐A time and decreased DST and MoCA scores. The NCT‐A, DST, MoCA, and sub‐domain scores were correlated with susceptibility values of RN, DN, SN, and CN, respectively. The susceptibility value of the left RN was a predictor variable for the DST, MoCA, and visuospatial–executive scores; those of the right CN and left RN were predictor variables for the naming score, and that of the left SN was an independent predictor variable for the language score. Conclusions Altered susceptibility values of DGM measured by QSM are potential quantitative indicators of cognitive impairment in cirrhotic patients. |
| format | Article |
| id | doaj-art-c5cdb8505f3b4ebab5f95d00bcc3e1f6 |
| institution | Kabale University |
| issn | 2162-3279 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj-art-c5cdb8505f3b4ebab5f95d00bcc3e1f62025-01-29T13:36:39ZengWileyBrain and Behavior2162-32792025-01-01151n/an/a10.1002/brb3.70240Quantitative Assessment of Deep Gray Matter Susceptibility and Correlation With Cognition in Patients With Liver CirrhosisWenjun Wu0Yu Su1Ziji Qin2Jiamin Kang3Dongqiao Xiang4Dingxi Liu5Chuansheng Zheng6E. Mark Haacke7Lixia Wang8Department of Radiology, Union Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChinaDepartment of Radiology, Union Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChinaDepartment of RadiologyThe People's Hospital of Guangxi Zhuang Autonomous RegionGuangxi Academy of Medical SciencesNanningChinaDepartment of Radiology, Wuhan No. 1 Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChinaDepartment of Radiology, Union Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChinaDepartment of Radiology, Union Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChinaDepartment of Radiology, Union Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChinaMagnetic Resonance InnovationsBingham FarmsMichiganUSADepartment of Radiology, Union Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChinaABSTRACT Background and Objectives Accumulation of metals quantified by quantitative susceptibility mapping (QSM) in deep gray matter (DGM) and their impact on cognition have not been studied in patients with liver cirrhosis. This study aims to use QSM to investigate the association between DGM susceptibility and cognition in cirrhotic patients. Methods Thirty cirrhotic patients and 30 age‐, gender‐, and education‐matched controls were imaged using a multiecho gradient‐echo sequence for QSM analysis in a 3T scanner. The susceptibility values were determined for the caudate nucleus (CN), putamen (PU), globus pallidus (GP), thalamus (TH), red nucleus (RN), substantia nigra (SN), and dentate nucleus (DN). All subjects underwent number connection test A (NCT‐A), digit substitution test (DST), and Montreal Cognitive Assessment (MoCA). Comparisons between the two groups and the correlation between the susceptibility values and neuropsychological scores were analyzed. Results The susceptibility values of bilateral CN, TH, and RN were significantly lower in cirrhotic patients. Cirrhotic patients exhibited significantly prolonged NCT‐A time and decreased DST and MoCA scores. The NCT‐A, DST, MoCA, and sub‐domain scores were correlated with susceptibility values of RN, DN, SN, and CN, respectively. The susceptibility value of the left RN was a predictor variable for the DST, MoCA, and visuospatial–executive scores; those of the right CN and left RN were predictor variables for the naming score, and that of the left SN was an independent predictor variable for the language score. Conclusions Altered susceptibility values of DGM measured by QSM are potential quantitative indicators of cognitive impairment in cirrhotic patients.https://doi.org/10.1002/brb3.70240liver cirrhosisdeep gray matterquantitative susceptibility mappingcognitive impairmentmetal accumulation |
| spellingShingle | Wenjun Wu Yu Su Ziji Qin Jiamin Kang Dongqiao Xiang Dingxi Liu Chuansheng Zheng E. Mark Haacke Lixia Wang Quantitative Assessment of Deep Gray Matter Susceptibility and Correlation With Cognition in Patients With Liver Cirrhosis Brain and Behavior liver cirrhosis deep gray matter quantitative susceptibility mapping cognitive impairment metal accumulation |
| title | Quantitative Assessment of Deep Gray Matter Susceptibility and Correlation With Cognition in Patients With Liver Cirrhosis |
| title_full | Quantitative Assessment of Deep Gray Matter Susceptibility and Correlation With Cognition in Patients With Liver Cirrhosis |
| title_fullStr | Quantitative Assessment of Deep Gray Matter Susceptibility and Correlation With Cognition in Patients With Liver Cirrhosis |
| title_full_unstemmed | Quantitative Assessment of Deep Gray Matter Susceptibility and Correlation With Cognition in Patients With Liver Cirrhosis |
| title_short | Quantitative Assessment of Deep Gray Matter Susceptibility and Correlation With Cognition in Patients With Liver Cirrhosis |
| title_sort | quantitative assessment of deep gray matter susceptibility and correlation with cognition in patients with liver cirrhosis |
| topic | liver cirrhosis deep gray matter quantitative susceptibility mapping cognitive impairment metal accumulation |
| url | https://doi.org/10.1002/brb3.70240 |
| work_keys_str_mv | AT wenjunwu quantitativeassessmentofdeepgraymattersusceptibilityandcorrelationwithcognitioninpatientswithlivercirrhosis AT yusu quantitativeassessmentofdeepgraymattersusceptibilityandcorrelationwithcognitioninpatientswithlivercirrhosis AT zijiqin quantitativeassessmentofdeepgraymattersusceptibilityandcorrelationwithcognitioninpatientswithlivercirrhosis AT jiaminkang quantitativeassessmentofdeepgraymattersusceptibilityandcorrelationwithcognitioninpatientswithlivercirrhosis AT dongqiaoxiang quantitativeassessmentofdeepgraymattersusceptibilityandcorrelationwithcognitioninpatientswithlivercirrhosis AT dingxiliu quantitativeassessmentofdeepgraymattersusceptibilityandcorrelationwithcognitioninpatientswithlivercirrhosis AT chuanshengzheng quantitativeassessmentofdeepgraymattersusceptibilityandcorrelationwithcognitioninpatientswithlivercirrhosis AT emarkhaacke quantitativeassessmentofdeepgraymattersusceptibilityandcorrelationwithcognitioninpatientswithlivercirrhosis AT lixiawang quantitativeassessmentofdeepgraymattersusceptibilityandcorrelationwithcognitioninpatientswithlivercirrhosis |