Comparative Study of Remimazolam and Midazolam During Sedated Upper Gastrointestinal Endoscopy: A Propensity Score Matching Analysis
ABSTRACT Aim This study aimed to compare the use of remimazolam and midazolam in upper gastrointestinal endoscopy in Japan as a sub‐analysis of data from an investigator‐initiated clinical trial of remimazolam. Methods and Results Patients in two groups were matched using propensity score matching....
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Wiley
2025-01-01
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| Series: | JGH Open |
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| Online Access: | https://doi.org/10.1002/jgh3.70100 |
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| author | Ryoji Ichijima Hisatomo Ikehara Tomomi Sugita Daisuke Yamaguchi Yasuhiko Nagata Kanako Ogura Mitsuru Esaki Yosuke Minoda Hiroyuki Ono Yuki Maeda Shinsuke Kiriyama Tetsuya Sumiyoshi Yuichi Kanmura |
| author_facet | Ryoji Ichijima Hisatomo Ikehara Tomomi Sugita Daisuke Yamaguchi Yasuhiko Nagata Kanako Ogura Mitsuru Esaki Yosuke Minoda Hiroyuki Ono Yuki Maeda Shinsuke Kiriyama Tetsuya Sumiyoshi Yuichi Kanmura |
| author_sort | Ryoji Ichijima |
| collection | DOAJ |
| description | ABSTRACT Aim This study aimed to compare the use of remimazolam and midazolam in upper gastrointestinal endoscopy in Japan as a sub‐analysis of data from an investigator‐initiated clinical trial of remimazolam. Methods and Results Patients in two groups were matched using propensity score matching. We evaluated the time from the end of the gastrointestinal endoscopy until discharge, the time from the end of the procedure until awakening, and adverse events. Overall, 36 participants from the clinical trial population who underwent upper gastrointestinal endoscopy using remimazolam and 199 patients who underwent the procedure with midazolam during the same period were included in this study. Following propensity score matching, 34 patients in both groups were matched. The median time from the end of the procedure until awakening was 27.0 min (23.0–40.5 min) in the midazolam group (Group M) and 0 min (0–5.0 min) in the remimazolam group (Group R); the median time from the end of the upper gastrointestinal endoscopy until discharge was 39.0 min (35.0–52.5 min) in Group M and 5.0 min (0–5.0 min) in Group R (p < 0.01). Reported adverse events were hypotension and hypoxemia in one patient in Group R. Conclusion Compared with midazolam, remimazolam significantly shortened the time to patient awakening and duration until the patient could leave the endoscopy room. Trial Registration: The main study (REM‐IICT JP1) is registered with the Japan Registry of Clinical Trails: jRCT2031200360 |
| format | Article |
| id | doaj-art-c5c61cada6934e53981ffa6be7ec9cc0 |
| institution | Kabale University |
| issn | 2397-9070 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | JGH Open |
| spelling | doaj-art-c5c61cada6934e53981ffa6be7ec9cc02025-01-28T09:24:32ZengWileyJGH Open2397-90702025-01-0191n/an/a10.1002/jgh3.70100Comparative Study of Remimazolam and Midazolam During Sedated Upper Gastrointestinal Endoscopy: A Propensity Score Matching AnalysisRyoji Ichijima0Hisatomo Ikehara1Tomomi Sugita2Daisuke Yamaguchi3Yasuhiko Nagata4Kanako Ogura5Mitsuru Esaki6Yosuke Minoda7Hiroyuki Ono8Yuki Maeda9Shinsuke Kiriyama10Tetsuya Sumiyoshi11Yuichi Kanmura12Division of Gastroenterology and Hepatology, Department of Medicine Nihon University School of Medicine Tokyo JapanDivision of Gastroenterology and Hepatology, Department of Medicine Nihon University School of Medicine Tokyo JapanDivision of Gastroenterology and Hepatology, Department of Medicine Nihon University School of Medicine Tokyo JapanDepartment of Gastroenterology National Hospital Organization Ureshino Medical Center Ureshino JapanDepartment of Gastroenterology Nagata Surgery and Gastroenterological Clinic Nishitokyo‐shi Tokyo JapanDivision of Gastroenterology and Hepatology, Department of Medicine Nihon University School of Medicine Tokyo JapanDepartment of Medicine and Bioregulatory Science, Graduate School of Medical Sciences Kyushu University Fukuoka JapanDepartment of Medicine and Bioregulatory Science, Graduate School of Medical Sciences Kyushu University Fukuoka JapanDivision of Endoscopy Shizuoka Cancer Center Shizuoka JapanDivision of Endoscopy Shizuoka Cancer Center Shizuoka JapanDepartment of Gastroenterology Kiriyama Clinic Takasaki Gunma JapanDepartment of Gastroenterology Tonan Hospital Hokkaido JapanDepartment of Anesthesiology Fujimoto General Hospital Miyazaki JapanABSTRACT Aim This study aimed to compare the use of remimazolam and midazolam in upper gastrointestinal endoscopy in Japan as a sub‐analysis of data from an investigator‐initiated clinical trial of remimazolam. Methods and Results Patients in two groups were matched using propensity score matching. We evaluated the time from the end of the gastrointestinal endoscopy until discharge, the time from the end of the procedure until awakening, and adverse events. Overall, 36 participants from the clinical trial population who underwent upper gastrointestinal endoscopy using remimazolam and 199 patients who underwent the procedure with midazolam during the same period were included in this study. Following propensity score matching, 34 patients in both groups were matched. The median time from the end of the procedure until awakening was 27.0 min (23.0–40.5 min) in the midazolam group (Group M) and 0 min (0–5.0 min) in the remimazolam group (Group R); the median time from the end of the upper gastrointestinal endoscopy until discharge was 39.0 min (35.0–52.5 min) in Group M and 5.0 min (0–5.0 min) in Group R (p < 0.01). Reported adverse events were hypotension and hypoxemia in one patient in Group R. Conclusion Compared with midazolam, remimazolam significantly shortened the time to patient awakening and duration until the patient could leave the endoscopy room. Trial Registration: The main study (REM‐IICT JP1) is registered with the Japan Registry of Clinical Trails: jRCT2031200360https://doi.org/10.1002/jgh3.70100endoscopygastrointestinalmidazolampropensity scoreremimazolam |
| spellingShingle | Ryoji Ichijima Hisatomo Ikehara Tomomi Sugita Daisuke Yamaguchi Yasuhiko Nagata Kanako Ogura Mitsuru Esaki Yosuke Minoda Hiroyuki Ono Yuki Maeda Shinsuke Kiriyama Tetsuya Sumiyoshi Yuichi Kanmura Comparative Study of Remimazolam and Midazolam During Sedated Upper Gastrointestinal Endoscopy: A Propensity Score Matching Analysis JGH Open endoscopy gastrointestinal midazolam propensity score remimazolam |
| title | Comparative Study of Remimazolam and Midazolam During Sedated Upper Gastrointestinal Endoscopy: A Propensity Score Matching Analysis |
| title_full | Comparative Study of Remimazolam and Midazolam During Sedated Upper Gastrointestinal Endoscopy: A Propensity Score Matching Analysis |
| title_fullStr | Comparative Study of Remimazolam and Midazolam During Sedated Upper Gastrointestinal Endoscopy: A Propensity Score Matching Analysis |
| title_full_unstemmed | Comparative Study of Remimazolam and Midazolam During Sedated Upper Gastrointestinal Endoscopy: A Propensity Score Matching Analysis |
| title_short | Comparative Study of Remimazolam and Midazolam During Sedated Upper Gastrointestinal Endoscopy: A Propensity Score Matching Analysis |
| title_sort | comparative study of remimazolam and midazolam during sedated upper gastrointestinal endoscopy a propensity score matching analysis |
| topic | endoscopy gastrointestinal midazolam propensity score remimazolam |
| url | https://doi.org/10.1002/jgh3.70100 |
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