Cellular Immunity of Patients with Tuberculosis Combined with Diabetes
Tuberculosis (TB) is one of humanity’s three major infectious diseases. Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia due to impaired insulin secretion or impaired insulin function. It has been reported that DM is a primary risk factor for TB disease. Given the increas...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2022/6837745 |
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| _version_ | 1832565743964651520 |
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| author | Peng Cheng Liang Wang Wenping Gong |
| author_facet | Peng Cheng Liang Wang Wenping Gong |
| author_sort | Peng Cheng |
| collection | DOAJ |
| description | Tuberculosis (TB) is one of humanity’s three major infectious diseases. Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia due to impaired insulin secretion or impaired insulin function. It has been reported that DM is a primary risk factor for TB disease. Given the increasing public health threat to people’s health, more and more studies have focused on diabetes complicated by TB. Hyperglycemia can affect the function of human immune cells, promote primary infections and reactivation of TB, and increase the susceptibility and severity of TB. However, the immunological mechanism behind it is still not clear. By reviewing the related articles on tuberculosis complicated with diabetes published in recent years, this paper expounds on the effect of hyperglycemia on innate immunity and adaptive immunity of patients with TB. This review provides new insights for elucidating the immunological mechanism of TB complicated with DM and lays the foundation for finding potential targets for preventing and treating TB combined with DM. |
| format | Article |
| id | doaj-art-c5bf4c2feda549fc9c450482eb80ad72 |
| institution | Kabale University |
| issn | 2314-7156 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-c5bf4c2feda549fc9c450482eb80ad722025-02-03T01:06:50ZengWileyJournal of Immunology Research2314-71562022-01-01202210.1155/2022/6837745Cellular Immunity of Patients with Tuberculosis Combined with DiabetesPeng Cheng0Liang Wang1Wenping Gong2Tuberculosis Prevention and Control Key Laboratory/Beijing Key Laboratory of New Techniques of Tuberculosis Diagnosis and TreatmentDepartment of GeriatricsTuberculosis Prevention and Control Key Laboratory/Beijing Key Laboratory of New Techniques of Tuberculosis Diagnosis and TreatmentTuberculosis (TB) is one of humanity’s three major infectious diseases. Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia due to impaired insulin secretion or impaired insulin function. It has been reported that DM is a primary risk factor for TB disease. Given the increasing public health threat to people’s health, more and more studies have focused on diabetes complicated by TB. Hyperglycemia can affect the function of human immune cells, promote primary infections and reactivation of TB, and increase the susceptibility and severity of TB. However, the immunological mechanism behind it is still not clear. By reviewing the related articles on tuberculosis complicated with diabetes published in recent years, this paper expounds on the effect of hyperglycemia on innate immunity and adaptive immunity of patients with TB. This review provides new insights for elucidating the immunological mechanism of TB complicated with DM and lays the foundation for finding potential targets for preventing and treating TB combined with DM.http://dx.doi.org/10.1155/2022/6837745 |
| spellingShingle | Peng Cheng Liang Wang Wenping Gong Cellular Immunity of Patients with Tuberculosis Combined with Diabetes Journal of Immunology Research |
| title | Cellular Immunity of Patients with Tuberculosis Combined with Diabetes |
| title_full | Cellular Immunity of Patients with Tuberculosis Combined with Diabetes |
| title_fullStr | Cellular Immunity of Patients with Tuberculosis Combined with Diabetes |
| title_full_unstemmed | Cellular Immunity of Patients with Tuberculosis Combined with Diabetes |
| title_short | Cellular Immunity of Patients with Tuberculosis Combined with Diabetes |
| title_sort | cellular immunity of patients with tuberculosis combined with diabetes |
| url | http://dx.doi.org/10.1155/2022/6837745 |
| work_keys_str_mv | AT pengcheng cellularimmunityofpatientswithtuberculosiscombinedwithdiabetes AT liangwang cellularimmunityofpatientswithtuberculosiscombinedwithdiabetes AT wenpinggong cellularimmunityofpatientswithtuberculosiscombinedwithdiabetes |