The influence of metformin treatment on the circulating proteomeResearch in context

Summary: Background: Metformin is one of the most used drugs worldwide. Given the increasing use of proteomics in trials, bioresources, and clinics, it is crucial to understand the influence of metformin on the levels of the circulating proteome. Methods: We analysed a combined longitudinal proteom...

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Main Authors:	Ben Connolly, Laura McCreight, Roderick C. Slieker, Khaled F. Bedair, Louise Donnelly, Juliette A. de Klerk, Joline W.J. Beulens, Petra J.M. Elders, Göran Bergström, Mun-Gwan Hong, Robert W. Koivula, Paul W. Franks, Jochen M. Schwenk, Anders Gummesson, Ewan R. Pearson, Leen M. ‘t Hart, Moustafa Abdalla, Jonathan Adam, Jerzy Adamski, Kofi Adragni, Rosa Lundbye L. Allesøe, Kristine H. Allin, Anna A. Artati, Manimozhiyan Arumugam, Naeimeh Atabaki Pasdar, Tania Baltauss, Karina Banasik, Anna Barnett, Patrick Baum, Jimmy D. Bell, Susanna Bianzano, Roberto Bizzotto, Amelie Bonnefond, Caroline Anna A. Brorsson, Andrew A. Brown, Søren Brunak, Louise Cabrelli, Robert Caiazzo, Henna Cederberg, Elizaveta Chabanova, Marc Clos-Garcia, Matilda Dale, David Davtian, Adem Y. Dawed, Federico De Masi, Nathalie de Preville, Koen F. Dekkers, Harshal A. Deshmukh, Christiane Dings, Avirup Dutta, Beate Ehrhardt, Line Engelbrechtsen, Rebeca Eriksen, Yong Fan, Juan Fernandez, Jorge Ferrer, Hugo Fitipaldi, Ian M. Forgie, Annemette Forman, Francesca Frau, Philippe Froguel, Gary Frost, Johann Gassenhuber, Giuseppe (Nick) N. Giordano, Toni Giorgino, Stephen Gough, Harald Grallert, Rolf Grempler, Lenka Groeneveld, Leif Groop, Valborg Gudmundsdóttir, Ramneek Gupta, Mark Haid, Torben Hansen, Tue H. Hansen, Andrew T. Hattersley, Ragna Haussler, Alison J. Heggie, Anita M. Hennige, Anita V. Hill, Reinhard W. Holl, Michelle Hudson, Bernd Jablonka, Ulrik Plesner Jacobsen, Christopher Jennison, Joachim Johansen, Angus G. Jones, Tugce Karaderi, Jane Kaye, Gwen Kennedy, Maria Klintenberg, Tarja Kokkola, Anitra D. Koopman, Azra Kurbasic, Teemu Kuulasmaa, Markku Laakso, Thorsten Lehr, Heather Loftus, Agnete Troen T. Lundgaard, Liwei Lyu, Anubha Mahajan, Andrea Mari, Gianluca Mazzoni, Mark I. McCarthy, Timothy J. McDonald, Donna McEvoy, Nicky McRobert, Ian McVittie, Miranda Mourby, Petra Musholt, Pascal Mutie, Rachel Nice, Claudia Nicolay, Giel Nijpels, Birgitte Nilsson, Colin N. Palmer, Francois Pattou, Imre Pavo, Helle K. Pedersen, Oluf Pedersen, Mandy H. Perry, Hugo Pomares-Millan, Cornelia P. Prehn, Anna Ramisch, Simon Rasmussen, Violeta Raverdi, Martin Ridderstråle, Neil Robertson, Marianne Rodriquez, Hartmut Ruetten, Femke Rutters, Peter Sackett, Nina Scherer, Nisha Shah, Sapna Sharma, Iryna Sihinevich, Nadja B. Sondertoft, Hans-Henrik Staerfeldt, Birgit Steckel-Hamann, Harriet Teare, Cecilia Engel E. Thomas, Elizabeth Louise L. Thomas, Melissa K. Thomas, Henrik S. Thomsen, Barbara Thorand, Claire E. Thorne, Joachim Tillner, Konstantinos D. Tsirigos, Andrea Tura, Mathias Uhlen, Sabine van Oort, Jagadish Vangipurapu, Helene Verkindt, Henrik Vestergaard, Ana Viñuela, Josef K. Vogt, Peter W. Wad Sackett, Mark Walker, Agata Wesolowska-Andersen, Brandon Whitcher, Margaret W. White, Alexander Efanov, Giuseppe N. Giordano, Gerard A. Bouland, Frédéric Burdet, Iulian Dragan, Andreas Festa, Michael K. Hansen, Dmitry Kuznetsov, Florence Mehl, Diana Marek, Kevin Duffin, Samreen K. Syed, Janice L. Shaw, Over Cabrera, Timothy J. Pullen, Bernard Thorens, Mark Ibberson, Guy A. Rutter
Format:	Article
Language:	English
Published:	Elsevier 2025-08-01
Series:	EBioMedicine
Subjects:	Metformin Proteomics Type 2 diabetes Biomarker
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352396425003032
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