Fetal Deaths in SARS-CoV-2-Infected Pregnant Women: A Portuguese Case Series
Introduction. Stillbirth has been documented as an outcome of SARS-CoV-2 infection in pregnancy. Placental hypoperfusion and inflammation secondary to maternal immune response seem to play a role in the cascade of events that contribute to fetal death. The aim of our study is to report a perinatal o...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Case Reports in Obstetrics and Gynecology |
| Online Access: | http://dx.doi.org/10.1155/2022/8423733 |
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| author | Ana Rita Mira João Pedro Pereira Catrine Dahlstedt-Ferreira Margarida Enes Hélder Oliveira Coelho Ana Beatriz Godinho |
| author_facet | Ana Rita Mira João Pedro Pereira Catrine Dahlstedt-Ferreira Margarida Enes Hélder Oliveira Coelho Ana Beatriz Godinho |
| author_sort | Ana Rita Mira |
| collection | DOAJ |
| description | Introduction. Stillbirth has been documented as an outcome of SARS-CoV-2 infection in pregnancy. Placental hypoperfusion and inflammation secondary to maternal immune response seem to play a role in the cascade of events that contribute to fetal death. The aim of our study is to report a perinatal outcome of SARS-CoV-2 infection in pregnancy adding information to the pool of data on COVID-19 pregnancy outcomes. Case Presentation. This is the first stillbirth case series occurring in pregnant women infected with SARS-CoV-2 in a Portuguese cohort. Between April 2020 and March 2021, we had 2680 births in our centre, of which 130 (4.95%) involved mothers infected with SARS-CoV-2. Of total births, there were 14 stillbirths (0.52%), accounting for the highest stillbirth rate we have had in the last 5 years. Among these 14 stillbirths, 5 (35.71%) occurred in SARS-CoV-2-infected mothers. We report the clinical features and placental histopathologic findings of 4 stillbirth cases that occurred in our hospital. Discussion. The stillbirth rate among SARS-CoV-2-infected pregnant women (5/130; 3.84%) was significantly increased compared to noninfected patients (9/2550; 0.35%). Most women (3/4) were asymptomatic for COVID-19, a surprising outcome, given the current literature. All cases had histologic exams showing placental signs of vascular malperfusion, although we acknowledge that 3/5 had obstetric conditions related to placental vascular impairment such as preeclampsia and HELLP syndrome. Conclusion. Stillbirth can be a perinatal consequence of SARS-CoV-2 infection in pregnancy, even in asymptomatic patients. We urge more studies to explore the association between SARS-CoV-2 infection and the risk of stillbirth. |
| format | Article |
| id | doaj-art-c5a531ecd17843009dd8662ce2a0867d |
| institution | Kabale University |
| issn | 2090-6692 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Obstetrics and Gynecology |
| spelling | doaj-art-c5a531ecd17843009dd8662ce2a0867d2025-02-03T06:04:40ZengWileyCase Reports in Obstetrics and Gynecology2090-66922022-01-01202210.1155/2022/8423733Fetal Deaths in SARS-CoV-2-Infected Pregnant Women: A Portuguese Case SeriesAna Rita Mira0João Pedro Pereira1Catrine Dahlstedt-Ferreira2Margarida Enes3Hélder Oliveira Coelho4Ana Beatriz Godinho5Obstetrics and GynaecologyObstetrics and GynaecologyPathologyObstetrics and GynaecologyPathologyObstetrics and GynaecologyIntroduction. Stillbirth has been documented as an outcome of SARS-CoV-2 infection in pregnancy. Placental hypoperfusion and inflammation secondary to maternal immune response seem to play a role in the cascade of events that contribute to fetal death. The aim of our study is to report a perinatal outcome of SARS-CoV-2 infection in pregnancy adding information to the pool of data on COVID-19 pregnancy outcomes. Case Presentation. This is the first stillbirth case series occurring in pregnant women infected with SARS-CoV-2 in a Portuguese cohort. Between April 2020 and March 2021, we had 2680 births in our centre, of which 130 (4.95%) involved mothers infected with SARS-CoV-2. Of total births, there were 14 stillbirths (0.52%), accounting for the highest stillbirth rate we have had in the last 5 years. Among these 14 stillbirths, 5 (35.71%) occurred in SARS-CoV-2-infected mothers. We report the clinical features and placental histopathologic findings of 4 stillbirth cases that occurred in our hospital. Discussion. The stillbirth rate among SARS-CoV-2-infected pregnant women (5/130; 3.84%) was significantly increased compared to noninfected patients (9/2550; 0.35%). Most women (3/4) were asymptomatic for COVID-19, a surprising outcome, given the current literature. All cases had histologic exams showing placental signs of vascular malperfusion, although we acknowledge that 3/5 had obstetric conditions related to placental vascular impairment such as preeclampsia and HELLP syndrome. Conclusion. Stillbirth can be a perinatal consequence of SARS-CoV-2 infection in pregnancy, even in asymptomatic patients. We urge more studies to explore the association between SARS-CoV-2 infection and the risk of stillbirth.http://dx.doi.org/10.1155/2022/8423733 |
| spellingShingle | Ana Rita Mira João Pedro Pereira Catrine Dahlstedt-Ferreira Margarida Enes Hélder Oliveira Coelho Ana Beatriz Godinho Fetal Deaths in SARS-CoV-2-Infected Pregnant Women: A Portuguese Case Series Case Reports in Obstetrics and Gynecology |
| title | Fetal Deaths in SARS-CoV-2-Infected Pregnant Women: A Portuguese Case Series |
| title_full | Fetal Deaths in SARS-CoV-2-Infected Pregnant Women: A Portuguese Case Series |
| title_fullStr | Fetal Deaths in SARS-CoV-2-Infected Pregnant Women: A Portuguese Case Series |
| title_full_unstemmed | Fetal Deaths in SARS-CoV-2-Infected Pregnant Women: A Portuguese Case Series |
| title_short | Fetal Deaths in SARS-CoV-2-Infected Pregnant Women: A Portuguese Case Series |
| title_sort | fetal deaths in sars cov 2 infected pregnant women a portuguese case series |
| url | http://dx.doi.org/10.1155/2022/8423733 |
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