Stage-Specific Serum Proteomic Signatures Reveal Early Biomarkers and Molecular Pathways in Huntington’s Disease Progression

Stage-Specific Serum Proteomic Signatures Reveal Early Biomarkers and Molecular Pathways in Huntington’s Disease Progression

Background: Huntington’s Disease (HD) is a monogenic neurodegenerative disease resulting in a CAG repeat expansion in the <i>HTT</i> gene. Despite this genetic simplicity, its molecular mechanisms remain highly complex. Methods: In this study, untargeted serum proteomics, bioinformatics...

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Bibliographic Details
Main Authors: Christiana C. Christodoulou, Christiana A. Demetriou, Eleni Zamba-Papanicolaou
Format: Article
Language:English
Published: MDPI AG 2025-08-01
Series:Cells
Subjects:
Huntington’s Disease
proteomics
serum analysis
proteins
bioinformatics
pathway analysis
Online Access:https://www.mdpi.com/2073-4409/14/15/1195
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