Fludarabine Treatment of Patient with Chronic Lymphocytic Leukemia Induces a Digital Ischemia
We report a 63-year-old man with a history of chronic lymphocytic leukemia (CLL) who presented with asymmetrical Raynaud’s phenomenon of sudden onset which progressed to acral gangrene rapidly in a week. These symptoms began approximately one week after the fourth cycle of fludarabine and cyclophosp...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2016/7362791 |
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| author | Utku Erdem Soyaltin Deniz Yuce Yildirim Mustafa Yildirim Mehmet Can Ugur Ferhat Ekinci Cengiz Ceylan Harun Akar |
| author_facet | Utku Erdem Soyaltin Deniz Yuce Yildirim Mustafa Yildirim Mehmet Can Ugur Ferhat Ekinci Cengiz Ceylan Harun Akar |
| author_sort | Utku Erdem Soyaltin |
| collection | DOAJ |
| description | We report a 63-year-old man with a history of chronic lymphocytic leukemia (CLL) who presented with asymmetrical Raynaud’s phenomenon of sudden onset which progressed to acral gangrene rapidly in a week. These symptoms began approximately one week after the fourth cycle of fludarabine and cyclophosphamide chemotherapy and were accompanied by pain, numbness, and cyanosis in the fingers of his right hand except the first finger. Fludarabine may play a role in acral vascular syndrome. The treatment with fludarabine in patients with evolving digital ischemia should be carried out with caution. |
| format | Article |
| id | doaj-art-c5986822706940ecb0bd7a71d59c56d3 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-c5986822706940ecb0bd7a71d59c56d32025-02-03T05:59:12ZengWileyCase Reports in Hematology2090-65602090-65792016-01-01201610.1155/2016/73627917362791Fludarabine Treatment of Patient with Chronic Lymphocytic Leukemia Induces a Digital IschemiaUtku Erdem Soyaltin0Deniz Yuce Yildirim1Mustafa Yildirim2Mehmet Can Ugur3Ferhat Ekinci4Cengiz Ceylan5Harun Akar6Tepecik Education and Research Hospital, Internal Medicine Clinic, Izmir, TurkeyTepecik Education and Research Hospital, Internal Medicine Clinic, Izmir, TurkeyTepecik Education and Research Hospital, Internal Medicine Clinic, Izmir, TurkeyTepecik Education and Research Hospital, Internal Medicine Clinic, Izmir, TurkeyDortyol Public Hospital, Hatay, TurkeyTepecik Education and Research Hospital, Hematology, Izmir, TurkeyTepecik Education and Research Hospital, Internal Medicine Clinic, Izmir, TurkeyWe report a 63-year-old man with a history of chronic lymphocytic leukemia (CLL) who presented with asymmetrical Raynaud’s phenomenon of sudden onset which progressed to acral gangrene rapidly in a week. These symptoms began approximately one week after the fourth cycle of fludarabine and cyclophosphamide chemotherapy and were accompanied by pain, numbness, and cyanosis in the fingers of his right hand except the first finger. Fludarabine may play a role in acral vascular syndrome. The treatment with fludarabine in patients with evolving digital ischemia should be carried out with caution.http://dx.doi.org/10.1155/2016/7362791 |
| spellingShingle | Utku Erdem Soyaltin Deniz Yuce Yildirim Mustafa Yildirim Mehmet Can Ugur Ferhat Ekinci Cengiz Ceylan Harun Akar Fludarabine Treatment of Patient with Chronic Lymphocytic Leukemia Induces a Digital Ischemia Case Reports in Hematology |
| title | Fludarabine Treatment of Patient with Chronic Lymphocytic Leukemia Induces a Digital Ischemia |
| title_full | Fludarabine Treatment of Patient with Chronic Lymphocytic Leukemia Induces a Digital Ischemia |
| title_fullStr | Fludarabine Treatment of Patient with Chronic Lymphocytic Leukemia Induces a Digital Ischemia |
| title_full_unstemmed | Fludarabine Treatment of Patient with Chronic Lymphocytic Leukemia Induces a Digital Ischemia |
| title_short | Fludarabine Treatment of Patient with Chronic Lymphocytic Leukemia Induces a Digital Ischemia |
| title_sort | fludarabine treatment of patient with chronic lymphocytic leukemia induces a digital ischemia |
| url | http://dx.doi.org/10.1155/2016/7362791 |
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