The Effects of Dexmedetomidine on Secondary Acute Lung and Kidney Injuries in the Rat Model of Intra-Abdominal Sepsis
In the present study, the effects of dexmedetomidine on secondary lung and kidney injuries were studied in the rat model of intra-abdominal sepsis by immunohistological and biochemical examinations. We measured serum creatinine, kidney tissue malondialdehide and plasma neutrophil gelatinase-associat...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/292687 |
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| author | Uğur Koca Çimen Gülben Olguner Bekir Uğur Ergür Emel Altekin Aydın Taşdöğen Seden Duru Pelin Girgin Kerim Gündüz Serap Cilaker Mıcılı Seda Güzeldağ Muhammed Akkuş |
| author_facet | Uğur Koca Çimen Gülben Olguner Bekir Uğur Ergür Emel Altekin Aydın Taşdöğen Seden Duru Pelin Girgin Kerim Gündüz Serap Cilaker Mıcılı Seda Güzeldağ Muhammed Akkuş |
| author_sort | Uğur Koca |
| collection | DOAJ |
| description | In the present study, the effects of dexmedetomidine on secondary lung and kidney injuries were studied in the rat model of intra-abdominal sepsis by immunohistological and biochemical examinations. We measured serum creatinine, kidney tissue malondialdehide and plasma neutrophil gelatinase-associated lipocalin levels. In order to evaluate tissue injury we determined kidney tissue mononuclear cell infiltration score, alveolar macrophage count, histological kidney and lung injury scores and kidney and lung tissue immunoreactivity scores. We demonstrated that dexmedetomidine attenuates sepsis-induced lung and kidney injuries and apoptosis in the rat model of sepsis. There is still need for comparative studies in order to determine the effects of dexmedetomidine on organ functions in early human sepsis. |
| format | Article |
| id | doaj-art-c58857a35b3a4582bc148056c1cf0a1c |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-c58857a35b3a4582bc148056c1cf0a1c2025-02-03T01:24:19ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/292687292687The Effects of Dexmedetomidine on Secondary Acute Lung and Kidney Injuries in the Rat Model of Intra-Abdominal SepsisUğur Koca0Çimen Gülben Olguner1Bekir Uğur Ergür2Emel Altekin3Aydın Taşdöğen4Seden Duru5Pelin Girgin6Kerim Gündüz7Serap Cilaker Mıcılı8Seda Güzeldağ9Muhammed Akkuş10Department of Anaesthesiology and Reanimation, School of Medicine, Dokuz Eylül University, Inciralti, 35340 İzmir, TurkeyDepartment of Anaesthesiology and Reanimation, School of Medicine, Dokuz Eylül University, Inciralti, 35340 İzmir, TurkeyDepartment of Histology and Embryology, School of Medicine, Dokuz Eylül University, İzmir, TurkeyDepartment of Biochemistry and Clinical Biochemistry, School of Medicine, Dokuz Eylül University, İzmir, TurkeyDepartment of Anaesthesiology and Reanimation, School of Medicine, Dokuz Eylül University, Inciralti, 35340 İzmir, TurkeyDepartment of Anaesthesiology and Reanimation, School of Medicine, Dokuz Eylül University, Inciralti, 35340 İzmir, TurkeyDepartment of Anaesthesiology and Reanimation, Şifa Hospital, 35240 İzmir, TurkeyDepartment of Biochemistry and Clinical Biochemistry, School of Medicine, Dokuz Eylül University, İzmir, TurkeyDepartment of Histology and Embryology, School of Medicine, Dokuz Eylül University, İzmir, TurkeyDepartment of Anaesthesiology and Reanimation, School of Medicine, Dokuz Eylül University, Inciralti, 35340 İzmir, TurkeyDepartment of Anaesthesiology and Reanimation, Samandağ State Hospital, 31800 Hatay, TurkeyIn the present study, the effects of dexmedetomidine on secondary lung and kidney injuries were studied in the rat model of intra-abdominal sepsis by immunohistological and biochemical examinations. We measured serum creatinine, kidney tissue malondialdehide and plasma neutrophil gelatinase-associated lipocalin levels. In order to evaluate tissue injury we determined kidney tissue mononuclear cell infiltration score, alveolar macrophage count, histological kidney and lung injury scores and kidney and lung tissue immunoreactivity scores. We demonstrated that dexmedetomidine attenuates sepsis-induced lung and kidney injuries and apoptosis in the rat model of sepsis. There is still need for comparative studies in order to determine the effects of dexmedetomidine on organ functions in early human sepsis.http://dx.doi.org/10.1155/2013/292687 |
| spellingShingle | Uğur Koca Çimen Gülben Olguner Bekir Uğur Ergür Emel Altekin Aydın Taşdöğen Seden Duru Pelin Girgin Kerim Gündüz Serap Cilaker Mıcılı Seda Güzeldağ Muhammed Akkuş The Effects of Dexmedetomidine on Secondary Acute Lung and Kidney Injuries in the Rat Model of Intra-Abdominal Sepsis The Scientific World Journal |
| title | The Effects of Dexmedetomidine on Secondary Acute Lung and Kidney Injuries in the Rat Model of Intra-Abdominal Sepsis |
| title_full | The Effects of Dexmedetomidine on Secondary Acute Lung and Kidney Injuries in the Rat Model of Intra-Abdominal Sepsis |
| title_fullStr | The Effects of Dexmedetomidine on Secondary Acute Lung and Kidney Injuries in the Rat Model of Intra-Abdominal Sepsis |
| title_full_unstemmed | The Effects of Dexmedetomidine on Secondary Acute Lung and Kidney Injuries in the Rat Model of Intra-Abdominal Sepsis |
| title_short | The Effects of Dexmedetomidine on Secondary Acute Lung and Kidney Injuries in the Rat Model of Intra-Abdominal Sepsis |
| title_sort | effects of dexmedetomidine on secondary acute lung and kidney injuries in the rat model of intra abdominal sepsis |
| url | http://dx.doi.org/10.1155/2013/292687 |
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