Prevalence and Possible Role of Candida Species in Patients with Psoriasis: A Systematic Review and Meta-Analysis
Although fungal colonization is implicated in the pathogenesis of psoriasis, its prevalence remains unclear. The aim of this systematic review and meta-analysis was to provide an overview on the prevalence of Candida species in patients with psoriasis. We searched databases (MEDLINE, EMBASE, Cochran...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2018/9602362 |
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| _version_ | 1832556775272873984 |
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| author | Aldona Pietrzak Ewelina Grywalska Mateusz Socha Jacek Roliński Kinga Franciszkiewicz-Pietrzak Lidia Rudnicka Marcin Rudzki Dorota Krasowska |
| author_facet | Aldona Pietrzak Ewelina Grywalska Mateusz Socha Jacek Roliński Kinga Franciszkiewicz-Pietrzak Lidia Rudnicka Marcin Rudzki Dorota Krasowska |
| author_sort | Aldona Pietrzak |
| collection | DOAJ |
| description | Although fungal colonization is implicated in the pathogenesis of psoriasis, its prevalence remains unclear. The aim of this systematic review and meta-analysis was to provide an overview on the prevalence of Candida species in patients with psoriasis. We searched databases (MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and http://clinicaltrials.gov) to identify studies involving subjects of any age with an established diagnosis of psoriasis and healthy controls, who were tested for carriage of Candida spp. on the skin or mucosal membranes (or saliva and stool), or presented with clinical candidiasis with microbiologically confirmed etiology. We identified nine cross-sectional studies including a total of 1038 subjects with psoriasis (psoriatics) and 669 controls. We found Candida species detection rates for psoriatics were significantly higher than those in the controls, especially in the oral mucosa milieux. These results suggest psoriasis may be one of the systemic diseases that predispose to oral Candida spp. carriage and infection. |
| format | Article |
| id | doaj-art-c56e5e7dbddd405c93489d33003af367 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-c56e5e7dbddd405c93489d33003af3672025-02-03T05:44:33ZengWileyMediators of Inflammation0962-93511466-18612018-01-01201810.1155/2018/96023629602362Prevalence and Possible Role of Candida Species in Patients with Psoriasis: A Systematic Review and Meta-AnalysisAldona Pietrzak0Ewelina Grywalska1Mateusz Socha2Jacek Roliński3Kinga Franciszkiewicz-Pietrzak4Lidia Rudnicka5Marcin Rudzki6Dorota Krasowska7Department of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, Ul. Radziwillowska 13, 20-080 Lublin, PolandDepartment of Clinical Immunology and Immunotherapy, Medical University of Lublin, Ul. Chodźki 4a, 20-093 Lublin, PolandDepartment of Internal Medicine and Cardiology, First Military Clinical Hospital with the Outpatient Clinic, Al. Racławickie 23, 20-048 Lublin, PolandDepartment of Clinical Immunology and Immunotherapy, Medical University of Lublin, Ul. Chodźki 4a, 20-093 Lublin, PolandDepartment of Surgical Oncology, Medical University of Lublin, Ul. Staszica 11, 20-081 Lublin, PolandDepartment of Dermatology, Medical University of Warsaw, Ul. Koszykowa 82a, 02-008 Warsaw, PolandChair and Department of Jaw Orthopaedics, Medical University of Lublin, Ul. Karmelicka 7, 20-081 Lublin, PolandDepartment of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, Ul. Radziwillowska 13, 20-080 Lublin, PolandAlthough fungal colonization is implicated in the pathogenesis of psoriasis, its prevalence remains unclear. The aim of this systematic review and meta-analysis was to provide an overview on the prevalence of Candida species in patients with psoriasis. We searched databases (MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and http://clinicaltrials.gov) to identify studies involving subjects of any age with an established diagnosis of psoriasis and healthy controls, who were tested for carriage of Candida spp. on the skin or mucosal membranes (or saliva and stool), or presented with clinical candidiasis with microbiologically confirmed etiology. We identified nine cross-sectional studies including a total of 1038 subjects with psoriasis (psoriatics) and 669 controls. We found Candida species detection rates for psoriatics were significantly higher than those in the controls, especially in the oral mucosa milieux. These results suggest psoriasis may be one of the systemic diseases that predispose to oral Candida spp. carriage and infection.http://dx.doi.org/10.1155/2018/9602362 |
| spellingShingle | Aldona Pietrzak Ewelina Grywalska Mateusz Socha Jacek Roliński Kinga Franciszkiewicz-Pietrzak Lidia Rudnicka Marcin Rudzki Dorota Krasowska Prevalence and Possible Role of Candida Species in Patients with Psoriasis: A Systematic Review and Meta-Analysis Mediators of Inflammation |
| title | Prevalence and Possible Role of Candida Species in Patients with Psoriasis: A Systematic Review and Meta-Analysis |
| title_full | Prevalence and Possible Role of Candida Species in Patients with Psoriasis: A Systematic Review and Meta-Analysis |
| title_fullStr | Prevalence and Possible Role of Candida Species in Patients with Psoriasis: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Prevalence and Possible Role of Candida Species in Patients with Psoriasis: A Systematic Review and Meta-Analysis |
| title_short | Prevalence and Possible Role of Candida Species in Patients with Psoriasis: A Systematic Review and Meta-Analysis |
| title_sort | prevalence and possible role of candida species in patients with psoriasis a systematic review and meta analysis |
| url | http://dx.doi.org/10.1155/2018/9602362 |
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