PLIN1 suppresses glioma progression through regulating lipid metabolism
Abstract Glioma is a common and destructive brain tumor, which is highly heterogeneous with poor prognosis. Developing diagnostic and prognostic markers to identify and treat glioma early would significantly improve the therapeutic outcomes. Here, we conducted RNA next-generation sequencing with 33...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2025-01-01
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| Series: | Cell Death and Disease |
| Online Access: | https://doi.org/10.1038/s41419-025-07347-z |
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| _version_ | 1832571265471217664 |
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| author | Kui Luo Kai Zhuang Hao Wu Yuanbing Chen Yi Liu Fan Yang Zhifei Wang |
| author_facet | Kui Luo Kai Zhuang Hao Wu Yuanbing Chen Yi Liu Fan Yang Zhifei Wang |
| author_sort | Kui Luo |
| collection | DOAJ |
| description | Abstract Glioma is a common and destructive brain tumor, which is highly heterogeneous with poor prognosis. Developing diagnostic and prognostic markers to identify and treat glioma early would significantly improve the therapeutic outcomes. Here, we conducted RNA next-generation sequencing with 33 glioma samples and 15 normal brain samples. We found Perilipin 1 (PLIN1) downregulated in glioma and correlated with poorer outcome. Subsequent experiments revealed that up regulation of PLIN1 led to repressed cell growth and invasion in glioma. Moreover, overexpression of PLIN1 increased lipid accumulation in glioma cells, with increasing expression of lipid biosynthesis related genes and decreasing expression of lipolysis related genes. Mechanically, we revealed that the PI3K/AKT axis could regulate PLIN1 levels in glioma, that inhibition of the activity of PI3K/AKT axis could increase PLIN1 levels in glioma. In conclusion, the dysregulation PI3K/AKT axis led to PLIN1 downregulation and the following tumor proliferation, invasion and lipid metabolism reprogramming in glioma. |
| format | Article |
| id | doaj-art-c564d9779ec245268b2e6bfbacafd3d3 |
| institution | Kabale University |
| issn | 2041-4889 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death and Disease |
| spelling | doaj-art-c564d9779ec245268b2e6bfbacafd3d32025-02-02T12:44:45ZengNature Publishing GroupCell Death and Disease2041-48892025-01-011611910.1038/s41419-025-07347-zPLIN1 suppresses glioma progression through regulating lipid metabolismKui Luo0Kai Zhuang1Hao Wu2Yuanbing Chen3Yi Liu4Fan Yang5Zhifei Wang6Department of Neurosurgery, The Third Xiangya Hospital, Central South UniversityDepartment of Neurosurgery, The Third Xiangya Hospital, Central South UniversityDepartment of Neurosurgery, The Third Xiangya Hospital, Central South UniversityDepartment of Neurosurgery, The Third Xiangya Hospital, Central South UniversityDepartment of Neurosurgery, The Third Xiangya Hospital, Central South UniversityDepartment of Neurosurgery, The Third Xiangya Hospital, Central South UniversityDepartment of Neurosurgery, The Third Xiangya Hospital, Central South UniversityAbstract Glioma is a common and destructive brain tumor, which is highly heterogeneous with poor prognosis. Developing diagnostic and prognostic markers to identify and treat glioma early would significantly improve the therapeutic outcomes. Here, we conducted RNA next-generation sequencing with 33 glioma samples and 15 normal brain samples. We found Perilipin 1 (PLIN1) downregulated in glioma and correlated with poorer outcome. Subsequent experiments revealed that up regulation of PLIN1 led to repressed cell growth and invasion in glioma. Moreover, overexpression of PLIN1 increased lipid accumulation in glioma cells, with increasing expression of lipid biosynthesis related genes and decreasing expression of lipolysis related genes. Mechanically, we revealed that the PI3K/AKT axis could regulate PLIN1 levels in glioma, that inhibition of the activity of PI3K/AKT axis could increase PLIN1 levels in glioma. In conclusion, the dysregulation PI3K/AKT axis led to PLIN1 downregulation and the following tumor proliferation, invasion and lipid metabolism reprogramming in glioma.https://doi.org/10.1038/s41419-025-07347-z |
| spellingShingle | Kui Luo Kai Zhuang Hao Wu Yuanbing Chen Yi Liu Fan Yang Zhifei Wang PLIN1 suppresses glioma progression through regulating lipid metabolism Cell Death and Disease |
| title | PLIN1 suppresses glioma progression through regulating lipid metabolism |
| title_full | PLIN1 suppresses glioma progression through regulating lipid metabolism |
| title_fullStr | PLIN1 suppresses glioma progression through regulating lipid metabolism |
| title_full_unstemmed | PLIN1 suppresses glioma progression through regulating lipid metabolism |
| title_short | PLIN1 suppresses glioma progression through regulating lipid metabolism |
| title_sort | plin1 suppresses glioma progression through regulating lipid metabolism |
| url | https://doi.org/10.1038/s41419-025-07347-z |
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