Conjugated Linoleic Acid Grafting Improved Hemocompatibility of the Polycaprolactone Electrospun Membrane

Polycaprolactone (PCL) is a versatile biomaterial with a wide range of medical applications, but its use in blood-contacting devices is hampered due to insufficient hemocompatibility. In this work, electrospun polycaprolactone (PCL) membranes were chemically grafted with conjugated linoleic acid (CL...

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Main Authors: Nam Minh-phuong Tran, Toan Le-duc Huynh, Binh Ngoc Phan, Nhi Ngoc-thao Dang, Thang Bach Phan, Huong Thi-thanh Ha, Long Phuoc Truong, Phu Dai Huynh, Ngoc Quyen Tran, Van Toi Vo, Phuong Thu Ha, Thi-Hiep Nguyen
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:International Journal of Polymer Science
Online Access:http://dx.doi.org/10.1155/2020/8127570
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author Nam Minh-phuong Tran
Toan Le-duc Huynh
Binh Ngoc Phan
Nhi Ngoc-thao Dang
Thang Bach Phan
Huong Thi-thanh Ha
Long Phuoc Truong
Phu Dai Huynh
Ngoc Quyen Tran
Van Toi Vo
Phuong Thu Ha
Thi-Hiep Nguyen
author_facet Nam Minh-phuong Tran
Toan Le-duc Huynh
Binh Ngoc Phan
Nhi Ngoc-thao Dang
Thang Bach Phan
Huong Thi-thanh Ha
Long Phuoc Truong
Phu Dai Huynh
Ngoc Quyen Tran
Van Toi Vo
Phuong Thu Ha
Thi-Hiep Nguyen
author_sort Nam Minh-phuong Tran
collection DOAJ
description Polycaprolactone (PCL) is a versatile biomaterial with a wide range of medical applications, but its use in blood-contacting devices is hampered due to insufficient hemocompatibility. In this work, electrospun polycaprolactone (PCL) membranes were chemically grafted with conjugated linoleic acid (CLA) to prevent induced blood coagulation. The density of grafted CLA and its effects on the morphology and wettability of the membranes were examined. The study also investigated how the membrane interacted with human whole blood and platelets to determine its antithrombotic properties. As the results suggested, the grafting caused a negligible effect on the physical properties of the membrane but greatly improved its compatibility with blood, showing that the approach can be investigated further for blood-contacting applications.
format Article
id doaj-art-c5417a18549f4e928eee7c8727b1e0c0
institution Kabale University
issn 1687-9422
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language English
publishDate 2020-01-01
publisher Wiley
record_format Article
series International Journal of Polymer Science
spelling doaj-art-c5417a18549f4e928eee7c8727b1e0c02025-02-03T00:58:49ZengWileyInternational Journal of Polymer Science1687-94221687-94302020-01-01202010.1155/2020/81275708127570Conjugated Linoleic Acid Grafting Improved Hemocompatibility of the Polycaprolactone Electrospun MembraneNam Minh-phuong Tran0Toan Le-duc Huynh1Binh Ngoc Phan2Nhi Ngoc-thao Dang3Thang Bach Phan4Huong Thi-thanh Ha5Long Phuoc Truong6Phu Dai Huynh7Ngoc Quyen Tran8Van Toi Vo9Phuong Thu Ha10Thi-Hiep Nguyen11Tissue Engineering and Regenerative Medicine Department, School of Biomedical Engineering, International University, Ho Chi Minh City, VietnamTissue Engineering and Regenerative Medicine Department, School of Biomedical Engineering, International University, Ho Chi Minh City, VietnamTissue Engineering and Regenerative Medicine Department, School of Biomedical Engineering, International University, Ho Chi Minh City, VietnamTissue Engineering and Regenerative Medicine Department, School of Biomedical Engineering, International University, Ho Chi Minh City, VietnamVietnam National University, Ho Chi Minh City, VietnamTissue Engineering and Regenerative Medicine Department, School of Biomedical Engineering, International University, Ho Chi Minh City, VietnamTissue Engineering and Regenerative Medicine Department, School of Biomedical Engineering, International University, Ho Chi Minh City, VietnamVietnam National University, Ho Chi Minh City, VietnamInstitute of Applied Materials Science, Vietnam Academy Science and Technology, Ho Chi Minh City, VietnamTissue Engineering and Regenerative Medicine Department, School of Biomedical Engineering, International University, Ho Chi Minh City, VietnamInstitute of Materials Science, Vietnam Academy of Science and Technology, Ha Noi, VietnamTissue Engineering and Regenerative Medicine Department, School of Biomedical Engineering, International University, Ho Chi Minh City, VietnamPolycaprolactone (PCL) is a versatile biomaterial with a wide range of medical applications, but its use in blood-contacting devices is hampered due to insufficient hemocompatibility. In this work, electrospun polycaprolactone (PCL) membranes were chemically grafted with conjugated linoleic acid (CLA) to prevent induced blood coagulation. The density of grafted CLA and its effects on the morphology and wettability of the membranes were examined. The study also investigated how the membrane interacted with human whole blood and platelets to determine its antithrombotic properties. As the results suggested, the grafting caused a negligible effect on the physical properties of the membrane but greatly improved its compatibility with blood, showing that the approach can be investigated further for blood-contacting applications.http://dx.doi.org/10.1155/2020/8127570
spellingShingle Nam Minh-phuong Tran
Toan Le-duc Huynh
Binh Ngoc Phan
Nhi Ngoc-thao Dang
Thang Bach Phan
Huong Thi-thanh Ha
Long Phuoc Truong
Phu Dai Huynh
Ngoc Quyen Tran
Van Toi Vo
Phuong Thu Ha
Thi-Hiep Nguyen
Conjugated Linoleic Acid Grafting Improved Hemocompatibility of the Polycaprolactone Electrospun Membrane
International Journal of Polymer Science
title Conjugated Linoleic Acid Grafting Improved Hemocompatibility of the Polycaprolactone Electrospun Membrane
title_full Conjugated Linoleic Acid Grafting Improved Hemocompatibility of the Polycaprolactone Electrospun Membrane
title_fullStr Conjugated Linoleic Acid Grafting Improved Hemocompatibility of the Polycaprolactone Electrospun Membrane
title_full_unstemmed Conjugated Linoleic Acid Grafting Improved Hemocompatibility of the Polycaprolactone Electrospun Membrane
title_short Conjugated Linoleic Acid Grafting Improved Hemocompatibility of the Polycaprolactone Electrospun Membrane
title_sort conjugated linoleic acid grafting improved hemocompatibility of the polycaprolactone electrospun membrane
url http://dx.doi.org/10.1155/2020/8127570
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