Conjugated Linoleic Acid Grafting Improved Hemocompatibility of the Polycaprolactone Electrospun Membrane
Polycaprolactone (PCL) is a versatile biomaterial with a wide range of medical applications, but its use in blood-contacting devices is hampered due to insufficient hemocompatibility. In this work, electrospun polycaprolactone (PCL) membranes were chemically grafted with conjugated linoleic acid (CL...
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Format: | Article |
Language: | English |
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Wiley
2020-01-01
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Series: | International Journal of Polymer Science |
Online Access: | http://dx.doi.org/10.1155/2020/8127570 |
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author | Nam Minh-phuong Tran Toan Le-duc Huynh Binh Ngoc Phan Nhi Ngoc-thao Dang Thang Bach Phan Huong Thi-thanh Ha Long Phuoc Truong Phu Dai Huynh Ngoc Quyen Tran Van Toi Vo Phuong Thu Ha Thi-Hiep Nguyen |
author_facet | Nam Minh-phuong Tran Toan Le-duc Huynh Binh Ngoc Phan Nhi Ngoc-thao Dang Thang Bach Phan Huong Thi-thanh Ha Long Phuoc Truong Phu Dai Huynh Ngoc Quyen Tran Van Toi Vo Phuong Thu Ha Thi-Hiep Nguyen |
author_sort | Nam Minh-phuong Tran |
collection | DOAJ |
description | Polycaprolactone (PCL) is a versatile biomaterial with a wide range of medical applications, but its use in blood-contacting devices is hampered due to insufficient hemocompatibility. In this work, electrospun polycaprolactone (PCL) membranes were chemically grafted with conjugated linoleic acid (CLA) to prevent induced blood coagulation. The density of grafted CLA and its effects on the morphology and wettability of the membranes were examined. The study also investigated how the membrane interacted with human whole blood and platelets to determine its antithrombotic properties. As the results suggested, the grafting caused a negligible effect on the physical properties of the membrane but greatly improved its compatibility with blood, showing that the approach can be investigated further for blood-contacting applications. |
format | Article |
id | doaj-art-c5417a18549f4e928eee7c8727b1e0c0 |
institution | Kabale University |
issn | 1687-9422 1687-9430 |
language | English |
publishDate | 2020-01-01 |
publisher | Wiley |
record_format | Article |
series | International Journal of Polymer Science |
spelling | doaj-art-c5417a18549f4e928eee7c8727b1e0c02025-02-03T00:58:49ZengWileyInternational Journal of Polymer Science1687-94221687-94302020-01-01202010.1155/2020/81275708127570Conjugated Linoleic Acid Grafting Improved Hemocompatibility of the Polycaprolactone Electrospun MembraneNam Minh-phuong Tran0Toan Le-duc Huynh1Binh Ngoc Phan2Nhi Ngoc-thao Dang3Thang Bach Phan4Huong Thi-thanh Ha5Long Phuoc Truong6Phu Dai Huynh7Ngoc Quyen Tran8Van Toi Vo9Phuong Thu Ha10Thi-Hiep Nguyen11Tissue Engineering and Regenerative Medicine Department, School of Biomedical Engineering, International University, Ho Chi Minh City, VietnamTissue Engineering and Regenerative Medicine Department, School of Biomedical Engineering, International University, Ho Chi Minh City, VietnamTissue Engineering and Regenerative Medicine Department, School of Biomedical Engineering, International University, Ho Chi Minh City, VietnamTissue Engineering and Regenerative Medicine Department, School of Biomedical Engineering, International University, Ho Chi Minh City, VietnamVietnam National University, Ho Chi Minh City, VietnamTissue Engineering and Regenerative Medicine Department, School of Biomedical Engineering, International University, Ho Chi Minh City, VietnamTissue Engineering and Regenerative Medicine Department, School of Biomedical Engineering, International University, Ho Chi Minh City, VietnamVietnam National University, Ho Chi Minh City, VietnamInstitute of Applied Materials Science, Vietnam Academy Science and Technology, Ho Chi Minh City, VietnamTissue Engineering and Regenerative Medicine Department, School of Biomedical Engineering, International University, Ho Chi Minh City, VietnamInstitute of Materials Science, Vietnam Academy of Science and Technology, Ha Noi, VietnamTissue Engineering and Regenerative Medicine Department, School of Biomedical Engineering, International University, Ho Chi Minh City, VietnamPolycaprolactone (PCL) is a versatile biomaterial with a wide range of medical applications, but its use in blood-contacting devices is hampered due to insufficient hemocompatibility. In this work, electrospun polycaprolactone (PCL) membranes were chemically grafted with conjugated linoleic acid (CLA) to prevent induced blood coagulation. The density of grafted CLA and its effects on the morphology and wettability of the membranes were examined. The study also investigated how the membrane interacted with human whole blood and platelets to determine its antithrombotic properties. As the results suggested, the grafting caused a negligible effect on the physical properties of the membrane but greatly improved its compatibility with blood, showing that the approach can be investigated further for blood-contacting applications.http://dx.doi.org/10.1155/2020/8127570 |
spellingShingle | Nam Minh-phuong Tran Toan Le-duc Huynh Binh Ngoc Phan Nhi Ngoc-thao Dang Thang Bach Phan Huong Thi-thanh Ha Long Phuoc Truong Phu Dai Huynh Ngoc Quyen Tran Van Toi Vo Phuong Thu Ha Thi-Hiep Nguyen Conjugated Linoleic Acid Grafting Improved Hemocompatibility of the Polycaprolactone Electrospun Membrane International Journal of Polymer Science |
title | Conjugated Linoleic Acid Grafting Improved Hemocompatibility of the Polycaprolactone Electrospun Membrane |
title_full | Conjugated Linoleic Acid Grafting Improved Hemocompatibility of the Polycaprolactone Electrospun Membrane |
title_fullStr | Conjugated Linoleic Acid Grafting Improved Hemocompatibility of the Polycaprolactone Electrospun Membrane |
title_full_unstemmed | Conjugated Linoleic Acid Grafting Improved Hemocompatibility of the Polycaprolactone Electrospun Membrane |
title_short | Conjugated Linoleic Acid Grafting Improved Hemocompatibility of the Polycaprolactone Electrospun Membrane |
title_sort | conjugated linoleic acid grafting improved hemocompatibility of the polycaprolactone electrospun membrane |
url | http://dx.doi.org/10.1155/2020/8127570 |
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