Restorative effects of camellia oil on the skin-barrier function in a model of DNCB-induced atopic dermatitis
This study aimed to evaluate the therapeutic efficacy of camellia oil on 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) in mice, as well as its effect on the expression of skin-barrier-related proteins. A mouse model of AD was created via topical application of DNCB; subsequently, t...
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PAGEPress Publications
2025-01-01
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| Series: | European Journal of Histochemistry |
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| Online Access: | https://www.ejh.it/index.php/ejh/article/view/4147 |
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| author | Shicheng Jiao Lijun Deng Mu Niu Jie Yang |
| author_facet | Shicheng Jiao Lijun Deng Mu Niu Jie Yang |
| author_sort | Shicheng Jiao |
| collection | DOAJ |
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This study aimed to evaluate the therapeutic efficacy of camellia oil on 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) in mice, as well as its effect on the expression of skin-barrier-related proteins. A mouse model of AD was created via topical application of DNCB; subsequently, the animals were randomly divided into four groups: the blank control (Control), model (Model), moisturizing cream (Moisturizer), and camellia oil (Camellia) groups. The Camellia group received camellia oil, whereas the Moisturizer group was treated with moisturizing cream, as a positive control. Skin lesions, ear and back tissue morphology, and the serum levels of IgE, IL-4, and IFN-γ were analyzed. Compared with the Control group, AD mice exhibited erythema, papules, dryness, peeling, and significantly higher serum IgE and IL-4 levels. Compared with the Model group, treatment with camellia oil and moisturizing cream considerably reduced skin inflammation, ear thickness, and scratching frequency. A histopathological analysis revealed that camellia oil reduced inflammatory-cell infiltration and edema in the AD-affected skin. Furthermore, camellia oil upregulated filaggrin (FLG), thus aiding in skin-barrier repair. These findings suggest that camellia oil significantly improves AD symptoms, enhances FLG expression, and restores the damaged skin barrier in AD mouse models.
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| format | Article |
| id | doaj-art-c52daca1abfc489f9e49bbf78ded1abb |
| institution | Kabale University |
| issn | 1121-760X 2038-8306 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | PAGEPress Publications |
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| series | European Journal of Histochemistry |
| spelling | doaj-art-c52daca1abfc489f9e49bbf78ded1abb2025-01-22T07:51:10ZengPAGEPress PublicationsEuropean Journal of Histochemistry1121-760X2038-83062025-01-0169110.4081/ejh.2025.4147Restorative effects of camellia oil on the skin-barrier function in a model of DNCB-induced atopic dermatitisShicheng Jiao0Lijun Deng1Mu Niu2Jie Yang3Jiao Shicheng Medical Beauty Clinic, Haikou, HainanDepartment of Dermatology, Wuzhong People’s Hospital, Suzhou, JiangsuDepartment of Dermatology, The Fifth People’s Hospital of Hainan Province, Affiliated Dermatology Hospital of Hainan Medical University, Haikou, HainanDepartment of Dermatology, The Fifth People’s Hospital of Hainan Province, Affiliated Dermatology Hospital of Hainan Medical University, Haikou, Hainan This study aimed to evaluate the therapeutic efficacy of camellia oil on 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) in mice, as well as its effect on the expression of skin-barrier-related proteins. A mouse model of AD was created via topical application of DNCB; subsequently, the animals were randomly divided into four groups: the blank control (Control), model (Model), moisturizing cream (Moisturizer), and camellia oil (Camellia) groups. The Camellia group received camellia oil, whereas the Moisturizer group was treated with moisturizing cream, as a positive control. Skin lesions, ear and back tissue morphology, and the serum levels of IgE, IL-4, and IFN-γ were analyzed. Compared with the Control group, AD mice exhibited erythema, papules, dryness, peeling, and significantly higher serum IgE and IL-4 levels. Compared with the Model group, treatment with camellia oil and moisturizing cream considerably reduced skin inflammation, ear thickness, and scratching frequency. A histopathological analysis revealed that camellia oil reduced inflammatory-cell infiltration and edema in the AD-affected skin. Furthermore, camellia oil upregulated filaggrin (FLG), thus aiding in skin-barrier repair. These findings suggest that camellia oil significantly improves AD symptoms, enhances FLG expression, and restores the damaged skin barrier in AD mouse models. https://www.ejh.it/index.php/ejh/article/view/4147Camellia oilatopic dermatitisDNCBskin barrierfilaggrinloricrin |
| spellingShingle | Shicheng Jiao Lijun Deng Mu Niu Jie Yang Restorative effects of camellia oil on the skin-barrier function in a model of DNCB-induced atopic dermatitis European Journal of Histochemistry Camellia oil atopic dermatitis DNCB skin barrier filaggrin loricrin |
| title | Restorative effects of camellia oil on the skin-barrier function in a model of DNCB-induced atopic dermatitis |
| title_full | Restorative effects of camellia oil on the skin-barrier function in a model of DNCB-induced atopic dermatitis |
| title_fullStr | Restorative effects of camellia oil on the skin-barrier function in a model of DNCB-induced atopic dermatitis |
| title_full_unstemmed | Restorative effects of camellia oil on the skin-barrier function in a model of DNCB-induced atopic dermatitis |
| title_short | Restorative effects of camellia oil on the skin-barrier function in a model of DNCB-induced atopic dermatitis |
| title_sort | restorative effects of camellia oil on the skin barrier function in a model of dncb induced atopic dermatitis |
| topic | Camellia oil atopic dermatitis DNCB skin barrier filaggrin loricrin |
| url | https://www.ejh.it/index.php/ejh/article/view/4147 |
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