Pyruvate and related energetic metabolites modulate resilience against high genetic risk for glaucoma

Pyruvate and related energetic metabolites modulate resilience against high genetic risk for glaucoma

A glaucoma polygenic risk score (PRS) can effectively identify disease risk, but some individuals with high PRS do not develop glaucoma. Factors contributing to this resilience remain unclear. Using 4,658 glaucoma cases and 113,040 controls in a cross-sectional study of the UK Biobank, we investigat...

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Main Authors: Keva Li, Nicholas Tolman, Ayellet V Segrè, Kelsey V Stuart, Oana A Zeleznik, Neeru A Vallabh, Kuang Hu, Nazlee Zebardast, Akiko Hanyuda, Yoshihiko Raita, Christa Montgomery, Chi Zhang, Pirro G Hysi, Ron Do, Anthony P Khawaja, Janey L Wiggs, Jae H Kang, Simon WM John, Louis R Pasquale, UK Biobank Eye and Vision Consortium
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-04-01
Series:eLife
Subjects:
metabolomics
genetics
glaucoma
pyruvate
glaucoma resilience
tricarboxylic acid cycle
Online Access:https://elifesciences.org/articles/105576
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