Thrombosis with thrombocytopenia after first dose of ChAdOx1 nCoV-19 vaccine: a case report
More than 5 billion vaccine doses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been administered worldwide. In Lithuania, more than 1.72 million people have been vaccinated with at least one vaccine dose. Vaccines against SARS-CoV-2 are considered to be safe and effecti...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Vilnius University Press
2021-12-01
|
| Series: | Neurologijos seminarai |
| Subjects: | |
| Online Access: | https://www.journals.vu.lt/neurologijos_seminarai/article/view/27610 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832593123192078336 |
|---|---|
| author | K. Kolodynskaja S. Stankevičiūtė A. Krikščionaitienė N. Balčiūnienė |
| author_facet | K. Kolodynskaja S. Stankevičiūtė A. Krikščionaitienė N. Balčiūnienė |
| author_sort | K. Kolodynskaja |
| collection | DOAJ |
| description |
More than 5 billion vaccine doses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been administered worldwide. In Lithuania, more than 1.72 million people have been vaccinated with at least one vaccine dose. Vaccines against SARS-CoV-2 are considered to be safe and effective measures to cope with COVID-19 pandemic. However, several cases of acute thrombotic events with thrombocytopenia after receiving ChAdOx1 nCoV-19 (AstraZeneca (Vaxzevria)) vaccine have been published. We report findings in one patient who presented with cerebral venous sinus thrombosis, intracerebral hemorrhage, and thrombocytopenia which occurred 12 days after receiving the first dose of ChAdOx1 nCoV-19 vaccine. The patient complained of headache and pain in the right eye, nausea, vomiting, and subfebrile fever. After deterioration of the state of consciousness, CT scan of the head showed a massive intracerebral hemorrhage, and laboratory tests revealed severe thrombocytopenia, high D-dimer level, and a low fibrinogen concentration. On the basis of clinical, laboratory and radiological findings, as well as the presence of antibodies to platelet factor 4 (PF4), the vaccine-induced immune thrombotic thrombocytopenia (VITT) was confirmed. After surgery and therapy with high doses of intravenous immunoglobulin, methylprednisolone and non-heparin anticoagulants, the patient’s clinical condition and laboratory parameters improved.
|
| format | Article |
| id | doaj-art-c51acd46e2784cd5a4d07d78127e9b30 |
| institution | Kabale University |
| issn | 1392-3064 2424-5917 |
| language | English |
| publishDate | 2021-12-01 |
| publisher | Vilnius University Press |
| record_format | Article |
| series | Neurologijos seminarai |
| spelling | doaj-art-c51acd46e2784cd5a4d07d78127e9b302025-01-20T18:22:17ZengVilnius University PressNeurologijos seminarai1392-30642424-59172021-12-01254(90)10.29014/ns.2021.32Thrombosis with thrombocytopenia after first dose of ChAdOx1 nCoV-19 vaccine: a case reportK. Kolodynskaja 0S. Stankevičiūtė 1A. Krikščionaitienė 2N. Balčiūnienė 3Lithuanian University of Health SciencesLithuanian University of Health SciencesLithuanian University of Health SciencesLithuanian University of Health Sciences More than 5 billion vaccine doses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been administered worldwide. In Lithuania, more than 1.72 million people have been vaccinated with at least one vaccine dose. Vaccines against SARS-CoV-2 are considered to be safe and effective measures to cope with COVID-19 pandemic. However, several cases of acute thrombotic events with thrombocytopenia after receiving ChAdOx1 nCoV-19 (AstraZeneca (Vaxzevria)) vaccine have been published. We report findings in one patient who presented with cerebral venous sinus thrombosis, intracerebral hemorrhage, and thrombocytopenia which occurred 12 days after receiving the first dose of ChAdOx1 nCoV-19 vaccine. The patient complained of headache and pain in the right eye, nausea, vomiting, and subfebrile fever. After deterioration of the state of consciousness, CT scan of the head showed a massive intracerebral hemorrhage, and laboratory tests revealed severe thrombocytopenia, high D-dimer level, and a low fibrinogen concentration. On the basis of clinical, laboratory and radiological findings, as well as the presence of antibodies to platelet factor 4 (PF4), the vaccine-induced immune thrombotic thrombocytopenia (VITT) was confirmed. After surgery and therapy with high doses of intravenous immunoglobulin, methylprednisolone and non-heparin anticoagulants, the patient’s clinical condition and laboratory parameters improved. https://www.journals.vu.lt/neurologijos_seminarai/article/view/27610COVID-19vaccinationthrombocytopeniathrombosisintracerebral hemorrhagevaccine-induced immune thrombotic thrombocytopenia |
| spellingShingle | K. Kolodynskaja S. Stankevičiūtė A. Krikščionaitienė N. Balčiūnienė Thrombosis with thrombocytopenia after first dose of ChAdOx1 nCoV-19 vaccine: a case report Neurologijos seminarai COVID-19 vaccination thrombocytopenia thrombosis intracerebral hemorrhage vaccine-induced immune thrombotic thrombocytopenia |
| title | Thrombosis with thrombocytopenia after first dose of ChAdOx1 nCoV-19 vaccine: a case report |
| title_full | Thrombosis with thrombocytopenia after first dose of ChAdOx1 nCoV-19 vaccine: a case report |
| title_fullStr | Thrombosis with thrombocytopenia after first dose of ChAdOx1 nCoV-19 vaccine: a case report |
| title_full_unstemmed | Thrombosis with thrombocytopenia after first dose of ChAdOx1 nCoV-19 vaccine: a case report |
| title_short | Thrombosis with thrombocytopenia after first dose of ChAdOx1 nCoV-19 vaccine: a case report |
| title_sort | thrombosis with thrombocytopenia after first dose of chadox1 ncov 19 vaccine a case report |
| topic | COVID-19 vaccination thrombocytopenia thrombosis intracerebral hemorrhage vaccine-induced immune thrombotic thrombocytopenia |
| url | https://www.journals.vu.lt/neurologijos_seminarai/article/view/27610 |
| work_keys_str_mv | AT kkolodynskaja thrombosiswiththrombocytopeniaafterfirstdoseofchadox1ncov19vaccineacasereport AT sstankeviciute thrombosiswiththrombocytopeniaafterfirstdoseofchadox1ncov19vaccineacasereport AT akrikscionaitiene thrombosiswiththrombocytopeniaafterfirstdoseofchadox1ncov19vaccineacasereport AT nbalciuniene thrombosiswiththrombocytopeniaafterfirstdoseofchadox1ncov19vaccineacasereport |