Ferritin as an Effective Prognostic Factor and Potential Cancer Biomarker
Ferritin is found in all cells of the body, serving as a reservoir of iron and protecting against damage to the molecules that make up cellular structures. It has emerged as a biomarker not only for iron-related disorders but also for inflammatory diseases and conditions in which inflammation plays...
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| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/47/1/60 |
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| author | Katarzyna Szymulewska-Konopko Joanna Reszeć-Giełażyn Monika Małeczek |
| author_facet | Katarzyna Szymulewska-Konopko Joanna Reszeć-Giełażyn Monika Małeczek |
| author_sort | Katarzyna Szymulewska-Konopko |
| collection | DOAJ |
| description | Ferritin is found in all cells of the body, serving as a reservoir of iron and protecting against damage to the molecules that make up cellular structures. It has emerged as a biomarker not only for iron-related disorders but also for inflammatory diseases and conditions in which inflammation plays a key role, including cancer, neurodegeneration, and infection. Oxidative stress, which can cause cellular damage, is induced by reactive oxygen species generated during the Fenton reaction, activating signaling pathways associated with tumor growth and proliferation. This review primarily emphasizes basic studies on the identification and function of ferritin, its essential role in iron metabolism, its involvement in inflammatory diseases, and its potential as an important prognostic factor and biomarker for cancer detection. |
| format | Article |
| id | doaj-art-c515abf9e69644558921e3d560275838 |
| institution | Kabale University |
| issn | 1467-3037 1467-3045 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj-art-c515abf9e69644558921e3d5602758382025-01-24T13:27:36ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452025-01-014716010.3390/cimb47010060Ferritin as an Effective Prognostic Factor and Potential Cancer BiomarkerKatarzyna Szymulewska-Konopko0Joanna Reszeć-Giełażyn1Monika Małeczek2Department of Medical Pathomorphology, Medical University of Bialystok, 15-089 Białystok, PolandDepartment of Medical Pathomorphology, Medical University of Bialystok, 15-089 Białystok, PolandDepartment of Medical Pathomorphology, Medical University of Bialystok, 15-089 Białystok, PolandFerritin is found in all cells of the body, serving as a reservoir of iron and protecting against damage to the molecules that make up cellular structures. It has emerged as a biomarker not only for iron-related disorders but also for inflammatory diseases and conditions in which inflammation plays a key role, including cancer, neurodegeneration, and infection. Oxidative stress, which can cause cellular damage, is induced by reactive oxygen species generated during the Fenton reaction, activating signaling pathways associated with tumor growth and proliferation. This review primarily emphasizes basic studies on the identification and function of ferritin, its essential role in iron metabolism, its involvement in inflammatory diseases, and its potential as an important prognostic factor and biomarker for cancer detection.https://www.mdpi.com/1467-3045/47/1/60ferritincancerbiomarker |
| spellingShingle | Katarzyna Szymulewska-Konopko Joanna Reszeć-Giełażyn Monika Małeczek Ferritin as an Effective Prognostic Factor and Potential Cancer Biomarker Current Issues in Molecular Biology ferritin cancer biomarker |
| title | Ferritin as an Effective Prognostic Factor and Potential Cancer Biomarker |
| title_full | Ferritin as an Effective Prognostic Factor and Potential Cancer Biomarker |
| title_fullStr | Ferritin as an Effective Prognostic Factor and Potential Cancer Biomarker |
| title_full_unstemmed | Ferritin as an Effective Prognostic Factor and Potential Cancer Biomarker |
| title_short | Ferritin as an Effective Prognostic Factor and Potential Cancer Biomarker |
| title_sort | ferritin as an effective prognostic factor and potential cancer biomarker |
| topic | ferritin cancer biomarker |
| url | https://www.mdpi.com/1467-3045/47/1/60 |
| work_keys_str_mv | AT katarzynaszymulewskakonopko ferritinasaneffectiveprognosticfactorandpotentialcancerbiomarker AT joannareszecgiełazyn ferritinasaneffectiveprognosticfactorandpotentialcancerbiomarker AT monikamałeczek ferritinasaneffectiveprognosticfactorandpotentialcancerbiomarker |