A neural network model enables worm tracking in challenging conditions and increases signal-to-noise ratio in phenotypic screens.

High-resolution posture tracking of C. elegans has applications in genetics, neuroscience, and drug screening. While classic methods can reliably track isolated worms on uniform backgrounds, they fail when worms overlap, coil, or move in complex environments. Model-based tracking and deep learning a...

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Bibliographic Details
Main Authors: Weheliye H Weheliye, Javier Rodriguez, Luigi Feriani, Avelino Javer, Virginie Uhlmann, André E X Brown
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-08-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1013345
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