Stress-Induced Premature Senescence or Stress-Induced Senescence-Like Phenotype: One In Vivo Reality, Two Possible Definitions?
No consensus exists so far on the definition of cellular senescence. The narrowest definition of senescence is irreversible growth arrest triggered by telomere shortening counting cell generations (definition 1). Other authors gave an enlarged functional definition encompassing any kind of irreversi...
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| Format: | Article |
| Language: | English |
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Wiley
2002-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2002.100 |
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| author | Olivier Toussaint Patrick Dumont Jose Remacle Jean-Francois Dierick Thierry Pascal Christophe Frippiat Joao Pedro Magalhaes Stephanie Zdanov Florence Chainiaux |
| author_facet | Olivier Toussaint Patrick Dumont Jose Remacle Jean-Francois Dierick Thierry Pascal Christophe Frippiat Joao Pedro Magalhaes Stephanie Zdanov Florence Chainiaux |
| author_sort | Olivier Toussaint |
| collection | DOAJ |
| description | No consensus exists so far on the definition of cellular senescence. The narrowest definition of senescence is irreversible growth arrest triggered by telomere shortening counting cell generations (definition 1). Other authors gave an enlarged functional definition encompassing any kind of irreversible arrest of proliferative cell types induced by damaging agents or cell cycle deregulations after overexpression of proto-oncogenes (definition 2). As stress increases, the proportion of cells in “stress-induced premature senescence-like phenotype” according to definition 1 or “stress-induced premature senescence,” according to definition 2, should increase when a culture reaches growth arrest, and the proportion of cells that reached telomere-dependent replicative senescence due to the end-replication problem should decrease. Stress-induced premature senescence-like phenotype and telomere-dependent replicatively senescent cells share basic similarities such as irreversible growth arrest and resistance to apoptosis, which may appear through different pathways. Irreversible growth arrest after exposure to oxidative stress and generation of DNA damage could be as efficient in avoiding immortalisation as “telomere-dependent” replicative senescence. Probabilities are higher that the senescent cells (according to definition 2) appearing in vivo are in stress-induced premature senescence rather than in telomere-dependent replicative senescence. Examples are given suggesting these cells affect in vivo tissue (patho)physiology and aging. |
| format | Article |
| id | doaj-art-c511149f88324325881c3f2b0796eae3 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2002-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-c511149f88324325881c3f2b0796eae32025-02-03T01:07:13ZengWileyThe Scientific World Journal1537-744X2002-01-01223024710.1100/tsw.2002.100Stress-Induced Premature Senescence or Stress-Induced Senescence-Like Phenotype: One In Vivo Reality, Two Possible Definitions?Olivier Toussaint0Patrick Dumont1Jose Remacle2Jean-Francois Dierick3Thierry Pascal4Christophe Frippiat5Joao Pedro Magalhaes6Stephanie Zdanov7Florence Chainiaux8University of Namur (FUNDP), Department of Biology, Research Unit of Cellular Biology (URBC), Namur, BelgiumDepartment of Pharmacology, Fox Chase Cancer Center, 7701 Burholme Ave., Philadelphia, PA 19111, USAUniversity of Namur (FUNDP), Department of Biology, Research Unit of Cellular Biology (URBC), Namur, BelgiumUniversity of Namur (FUNDP), Department of Biology, Research Unit of Cellular Biology (URBC), Namur, BelgiumUniversity of Namur (FUNDP), Department of Biology, Research Unit of Cellular Biology (URBC), Namur, BelgiumUniversity of Namur (FUNDP), Department of Biology, Research Unit of Cellular Biology (URBC), Namur, BelgiumUniversity of Namur (FUNDP), Department of Biology, Research Unit of Cellular Biology (URBC), Namur, BelgiumUniversity of Namur (FUNDP), Department of Biology, Research Unit of Cellular Biology (URBC), Namur, BelgiumUniversity of Namur (FUNDP), Department of Biology, Research Unit of Cellular Biology (URBC), Namur, BelgiumNo consensus exists so far on the definition of cellular senescence. The narrowest definition of senescence is irreversible growth arrest triggered by telomere shortening counting cell generations (definition 1). Other authors gave an enlarged functional definition encompassing any kind of irreversible arrest of proliferative cell types induced by damaging agents or cell cycle deregulations after overexpression of proto-oncogenes (definition 2). As stress increases, the proportion of cells in “stress-induced premature senescence-like phenotype” according to definition 1 or “stress-induced premature senescence,” according to definition 2, should increase when a culture reaches growth arrest, and the proportion of cells that reached telomere-dependent replicative senescence due to the end-replication problem should decrease. Stress-induced premature senescence-like phenotype and telomere-dependent replicatively senescent cells share basic similarities such as irreversible growth arrest and resistance to apoptosis, which may appear through different pathways. Irreversible growth arrest after exposure to oxidative stress and generation of DNA damage could be as efficient in avoiding immortalisation as “telomere-dependent” replicative senescence. Probabilities are higher that the senescent cells (according to definition 2) appearing in vivo are in stress-induced premature senescence rather than in telomere-dependent replicative senescence. Examples are given suggesting these cells affect in vivo tissue (patho)physiology and aging.http://dx.doi.org/10.1100/tsw.2002.100 |
| spellingShingle | Olivier Toussaint Patrick Dumont Jose Remacle Jean-Francois Dierick Thierry Pascal Christophe Frippiat Joao Pedro Magalhaes Stephanie Zdanov Florence Chainiaux Stress-Induced Premature Senescence or Stress-Induced Senescence-Like Phenotype: One In Vivo Reality, Two Possible Definitions? The Scientific World Journal |
| title | Stress-Induced Premature Senescence or Stress-Induced Senescence-Like Phenotype: One In Vivo Reality, Two Possible Definitions? |
| title_full | Stress-Induced Premature Senescence or Stress-Induced Senescence-Like Phenotype: One In Vivo Reality, Two Possible Definitions? |
| title_fullStr | Stress-Induced Premature Senescence or Stress-Induced Senescence-Like Phenotype: One In Vivo Reality, Two Possible Definitions? |
| title_full_unstemmed | Stress-Induced Premature Senescence or Stress-Induced Senescence-Like Phenotype: One In Vivo Reality, Two Possible Definitions? |
| title_short | Stress-Induced Premature Senescence or Stress-Induced Senescence-Like Phenotype: One In Vivo Reality, Two Possible Definitions? |
| title_sort | stress induced premature senescence or stress induced senescence like phenotype one in vivo reality two possible definitions |
| url | http://dx.doi.org/10.1100/tsw.2002.100 |
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