Cognitive Impairments in LRRK2-Related Parkinson’s Disease: A Study in Chinese Individuals
Background. LRRK2 S1647T has been identified as a polymorphic risk variant for Parkinson’s disease (PD) in Chinese individuals. As LRRK2 is the most common genetic cause for PD, it has drawn great interest regarding whether cognitive impairments in PD are related with LRRK2. Purpose. This study ai...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2015/621873 |
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| author | Yifan Zheng Zhong Pei Yanmei Liu Hongyan Zhou Wenbiao Xian Yingying Fang Ling Chen Qi Wu |
| author_facet | Yifan Zheng Zhong Pei Yanmei Liu Hongyan Zhou Wenbiao Xian Yingying Fang Ling Chen Qi Wu |
| author_sort | Yifan Zheng |
| collection | DOAJ |
| description | Background. LRRK2 S1647T has been identified as a polymorphic risk variant for Parkinson’s disease (PD) in Chinese individuals. As LRRK2 is the most common genetic cause for PD, it has drawn great interest regarding whether cognitive impairments in PD are related with LRRK2. Purpose. This study aimed to explore the effects of LRRK2 S1647T polymorphism on cognitive function in PD. Method. 90 PD patients were randomly recruited. They underwent a series of clinical evaluations and genetic testing for the LRRK2 S1647T polymorphism. Global intellect and five cognitive domains (language fluency, visuospatial function, attention, memory, and executive function) were compared between S1647T carriers and noncarriers. Results. No differences in motor features were found between two groups, but the executive function evaluation showed that Stroop word colour test time (SWCT-TIME) scores were lower in LRRK2 S1647T carriers than in noncarriers (P=0.017). However, multiple linear regression analysis indicated that the correlation between S1647T polymorphism and SWCT-TIME scores did not reach significant level (P=0.051). Conclusion. Our findings suggest that cognitive impairments are not correlated with different LRRK2 S1647T polymorphisms in Chinese PD individuals. |
| format | Article |
| id | doaj-art-c50a59e71a8e440ba14a5b64a21176c0 |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-c50a59e71a8e440ba14a5b64a21176c02025-02-03T06:46:17ZengWileyBehavioural Neurology0953-41801875-85842015-01-01201510.1155/2015/621873621873Cognitive Impairments in LRRK2-Related Parkinson’s Disease: A Study in Chinese IndividualsYifan Zheng0Zhong Pei1Yanmei Liu2Hongyan Zhou3Wenbiao Xian4Yingying Fang5Ling Chen6Qi Wu7Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, ChinaDepartment of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, ChinaDepartment of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, ChinaDepartment of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, ChinaDepartment of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, ChinaDepartment of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, ChinaDepartment of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, ChinaDepartment of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, ChinaBackground. LRRK2 S1647T has been identified as a polymorphic risk variant for Parkinson’s disease (PD) in Chinese individuals. As LRRK2 is the most common genetic cause for PD, it has drawn great interest regarding whether cognitive impairments in PD are related with LRRK2. Purpose. This study aimed to explore the effects of LRRK2 S1647T polymorphism on cognitive function in PD. Method. 90 PD patients were randomly recruited. They underwent a series of clinical evaluations and genetic testing for the LRRK2 S1647T polymorphism. Global intellect and five cognitive domains (language fluency, visuospatial function, attention, memory, and executive function) were compared between S1647T carriers and noncarriers. Results. No differences in motor features were found between two groups, but the executive function evaluation showed that Stroop word colour test time (SWCT-TIME) scores were lower in LRRK2 S1647T carriers than in noncarriers (P=0.017). However, multiple linear regression analysis indicated that the correlation between S1647T polymorphism and SWCT-TIME scores did not reach significant level (P=0.051). Conclusion. Our findings suggest that cognitive impairments are not correlated with different LRRK2 S1647T polymorphisms in Chinese PD individuals.http://dx.doi.org/10.1155/2015/621873 |
| spellingShingle | Yifan Zheng Zhong Pei Yanmei Liu Hongyan Zhou Wenbiao Xian Yingying Fang Ling Chen Qi Wu Cognitive Impairments in LRRK2-Related Parkinson’s Disease: A Study in Chinese Individuals Behavioural Neurology |
| title | Cognitive Impairments in LRRK2-Related Parkinson’s Disease: A Study in Chinese Individuals |
| title_full | Cognitive Impairments in LRRK2-Related Parkinson’s Disease: A Study in Chinese Individuals |
| title_fullStr | Cognitive Impairments in LRRK2-Related Parkinson’s Disease: A Study in Chinese Individuals |
| title_full_unstemmed | Cognitive Impairments in LRRK2-Related Parkinson’s Disease: A Study in Chinese Individuals |
| title_short | Cognitive Impairments in LRRK2-Related Parkinson’s Disease: A Study in Chinese Individuals |
| title_sort | cognitive impairments in lrrk2 related parkinson s disease a study in chinese individuals |
| url | http://dx.doi.org/10.1155/2015/621873 |
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