Water quality and neurodegenerative disease risk in the middle-aged and elderly population
Ensuring sustainable management of water is an indispensable part of sustainable development, however, the limelight on long-term health risk of water hardness is essential but remains inadequate. This study estimated effects of water hardness on the brain system to refine its systemic risk assessme...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651324017238 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832590988010323968 |
|---|---|
| author | Yujia Bao Yongxuan Li Yanqiu Zhou Jingqi Zhou Wei Mu Xiaobei Deng Chen Shen Lefei Han Jinjun Ran |
| author_facet | Yujia Bao Yongxuan Li Yanqiu Zhou Jingqi Zhou Wei Mu Xiaobei Deng Chen Shen Lefei Han Jinjun Ran |
| author_sort | Yujia Bao |
| collection | DOAJ |
| description | Ensuring sustainable management of water is an indispensable part of sustainable development, however, the limelight on long-term health risk of water hardness is essential but remains inadequate. This study estimated effects of water hardness on the brain system to refine its systemic risk assessment. We assembled a cohort of 397,265 participants from the UK Biobank to investigate the associations of water hardness with neurodegenerative diseases and brain imaging phenotypes through modeling. We found water hardness in 0–120 mg/L elevated the incidence risks of Alzheimer’s disease and vascular dementia compared to that in 120–300 mg/L, with hazard ratios of 1.13 (1.01, 1.27) and 1.24 (1.05, 1.46), respectively. Furthermore, the associations with partial cerebral atrophy were also observed, including the caudate nucleus and inferior parietal lobule. Our study provides insights into the importance of enacting more precise guidelines about water hardness and contributes to the achievement of the Sustainable Development Goals. |
| format | Article |
| id | doaj-art-c50572521ed74f408480b974bab54c92 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-c50572521ed74f408480b974bab54c922025-01-23T05:25:57ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01289117647Water quality and neurodegenerative disease risk in the middle-aged and elderly populationYujia Bao0Yongxuan Li1Yanqiu Zhou2Jingqi Zhou3Wei Mu4Xiaobei Deng5Chen Shen6Lefei Han7Jinjun Ran8School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaSchool of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaSchool of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaSchool of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaSchool of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaSchool of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaMRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, UKSchool of Global Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Correspondence to: School of Global Health, Shanghai Jiao Tong University School of Medicine, 412 West No. 1 Bldg, 280 South Chongqing Rd., Shanghai 200025, China.School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Correspondence to: School of Public Health, Shanghai Jiao Tong University School of Medicine, 413 East No. 1 Bldg, 227 South Chongqing Rd., Shanghai 200025, China.Ensuring sustainable management of water is an indispensable part of sustainable development, however, the limelight on long-term health risk of water hardness is essential but remains inadequate. This study estimated effects of water hardness on the brain system to refine its systemic risk assessment. We assembled a cohort of 397,265 participants from the UK Biobank to investigate the associations of water hardness with neurodegenerative diseases and brain imaging phenotypes through modeling. We found water hardness in 0–120 mg/L elevated the incidence risks of Alzheimer’s disease and vascular dementia compared to that in 120–300 mg/L, with hazard ratios of 1.13 (1.01, 1.27) and 1.24 (1.05, 1.46), respectively. Furthermore, the associations with partial cerebral atrophy were also observed, including the caudate nucleus and inferior parietal lobule. Our study provides insights into the importance of enacting more precise guidelines about water hardness and contributes to the achievement of the Sustainable Development Goals.http://www.sciencedirect.com/science/article/pii/S0147651324017238Environmental epidemiologyNeurodegenerative diseaseBrain healthDrinking water qualityHuman health effect |
| spellingShingle | Yujia Bao Yongxuan Li Yanqiu Zhou Jingqi Zhou Wei Mu Xiaobei Deng Chen Shen Lefei Han Jinjun Ran Water quality and neurodegenerative disease risk in the middle-aged and elderly population Ecotoxicology and Environmental Safety Environmental epidemiology Neurodegenerative disease Brain health Drinking water quality Human health effect |
| title | Water quality and neurodegenerative disease risk in the middle-aged and elderly population |
| title_full | Water quality and neurodegenerative disease risk in the middle-aged and elderly population |
| title_fullStr | Water quality and neurodegenerative disease risk in the middle-aged and elderly population |
| title_full_unstemmed | Water quality and neurodegenerative disease risk in the middle-aged and elderly population |
| title_short | Water quality and neurodegenerative disease risk in the middle-aged and elderly population |
| title_sort | water quality and neurodegenerative disease risk in the middle aged and elderly population |
| topic | Environmental epidemiology Neurodegenerative disease Brain health Drinking water quality Human health effect |
| url | http://www.sciencedirect.com/science/article/pii/S0147651324017238 |
| work_keys_str_mv | AT yujiabao waterqualityandneurodegenerativediseaseriskinthemiddleagedandelderlypopulation AT yongxuanli waterqualityandneurodegenerativediseaseriskinthemiddleagedandelderlypopulation AT yanqiuzhou waterqualityandneurodegenerativediseaseriskinthemiddleagedandelderlypopulation AT jingqizhou waterqualityandneurodegenerativediseaseriskinthemiddleagedandelderlypopulation AT weimu waterqualityandneurodegenerativediseaseriskinthemiddleagedandelderlypopulation AT xiaobeideng waterqualityandneurodegenerativediseaseriskinthemiddleagedandelderlypopulation AT chenshen waterqualityandneurodegenerativediseaseriskinthemiddleagedandelderlypopulation AT lefeihan waterqualityandneurodegenerativediseaseriskinthemiddleagedandelderlypopulation AT jinjunran waterqualityandneurodegenerativediseaseriskinthemiddleagedandelderlypopulation |