Expanding the structural resolution of glycosylation microheterogeneity in therapeutic proteins by salt-free hydrophilic interaction liquid chromatography tandem mass spectrometry

Expanding the structural resolution of glycosylation microheterogeneity in therapeutic proteins by salt-free hydrophilic interaction liquid chromatography tandem mass spectrometry

Glycosylation affects the safety and efficacy of therapeutic proteins and is often considered a critical quality attribute (CQA). Therefore, it is important to identify and quantify glycans during drug development. Glycosylation is a highly complex post-translational modification (PTM) due to its st...

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Bibliographic Details
Main Authors: Yutian Gan, Steffen Lippold, John Stobaugh, Christian Schöneich, Feng Yang
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:mAbs
Subjects:
Critical quality attribute
glycopeptide
hydrophilic interaction liquid chromatography
mass spectrometry
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2024.2395503
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