VEGF-B-mediated myofiber types involved in high-fat diet-induced hyperglycemia through PKA-NFATs signaling pathway

VEGF-B-mediated myofiber types involved in high-fat diet-induced hyperglycemia through PKA-NFATs signaling pathway

Abstract Background Hyperglycemia and insulin resistance are among the key phenotypes of obesity and type 2 diabetes (T2DM). Notably, skeletal muscle fiber-type composition is closely linked to insulin resistance. Vascular endothelial growth factor B (VEGF-B) has been shown to play an important role...

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Main Authors: Liu-liu Shi, Yu-ting Sun, Jia-nan Sun, Jing Yue, Wei Chen, Kun Meng, Long Chen, Chang-qing Hu, Rui Chen, Dong-sheng Sun, Cheng-bao Xu, Wei Yuan, Xin-li Li, Dan Zhao, Yan Wu, Shi-bing Xi, Xiao-ying Zhao, Jun-ming Tang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Stem Cell Research & Therapy
Subjects:
VEGF-B
Myoblast differentiation/fusion
Myofiber types
Hyperglycemia
Obesity
T2DM
Online Access:https://doi.org/10.1186/s13287-025-04455-7
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