Toward an effective delivery system of a microbial sink of the uremic toxin, p-cresol; an in vitro study with Thauera aminoaromatica S2

Toward an effective delivery system of a microbial sink of the uremic toxin, p-cresol; an in vitro study with Thauera aminoaromatica S2

Individuals with chronic kidney disease (CKD) suffer from uremia, a condition characterized by the accumulation of uremic toxin in the blood. The aromatic uremic toxin p-cresol, a byproduct of tyrosine fermentation in the gut, binds to plasma albumin and cannot be removed with dialysis. However, the...

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Bibliographic Details
Main Authors: Prakit Saingam, Rosita Rasyid, Britt Abrahamson, Thomas J. Lie, Bruce J. Godfrey, Jonathan Himmelfarb, Mari K. H. Winkler
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Microbiology
Subjects:
uremic toxin
hydrogel encapsulation
oral delivery method
p-cresol degrading microorganism
intestinal p-cresol removal
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1577556/full
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