Nitric Oxide Concentration and Other Salivary Changes after Insertion of New Complete Dentures in Edentulous Subjects
Objective. To assess changes in levels of salivary nitric oxide (NO) after insertion of new complete dentures and its association with clinical and salivary parameters. Methods. Nineteen fully edentulous subjects were included, mean age 64.4. Unstimulated whole saliva was collected before and after...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | International Journal of Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2016/8351427 |
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| author | Maria de Lourdes Breseghelo Lídia Andreu Guillo Túlio Eduardo Nogueira Cláudio Rodrigues Leles |
| author_facet | Maria de Lourdes Breseghelo Lídia Andreu Guillo Túlio Eduardo Nogueira Cláudio Rodrigues Leles |
| author_sort | Maria de Lourdes Breseghelo |
| collection | DOAJ |
| description | Objective. To assess changes in levels of salivary nitric oxide (NO) after insertion of new complete dentures and its association with clinical and salivary parameters. Methods. Nineteen fully edentulous subjects were included, mean age 64.4. Unstimulated whole saliva was collected before and after insertion of the dentures, at follow-up visits, and after 12 months. The concentration of the final stable NO product (nitrite) was measured by a colorimetric assay based on the Griess reaction. Clinical parameters were assessed during all clinical visits. Results. Functional adaptation to the dentures progressively improved, with no complaints at the long-term follow-up. NO concentration was not influenced by the level of functional adaptation, presence of injuries to the mucosa, salivary flow, and saliva viscosity. Pairwise comparison showed a reduction in NO concentration at the first follow-up compared to baseline values but differences were not statistically significant. Significant differences were observed in NO concentrations at the long-term follow-up when compared to the first (p=0.024) and second (p=0.027) visits. Conclusion. NO concentration reduced after denture insertion and returned to baseline levels in the long-term follow-up. This appears to be an autonomic response of the body and provides valuable complementary information for the management of the edentulous patient. |
| format | Article |
| id | doaj-art-c4f01466e2aa4df885fecc1fa9b746a2 |
| institution | Kabale University |
| issn | 1687-8728 1687-8736 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Dentistry |
| spelling | doaj-art-c4f01466e2aa4df885fecc1fa9b746a22025-02-03T01:12:36ZengWileyInternational Journal of Dentistry1687-87281687-87362016-01-01201610.1155/2016/83514278351427Nitric Oxide Concentration and Other Salivary Changes after Insertion of New Complete Dentures in Edentulous SubjectsMaria de Lourdes Breseghelo0Lídia Andreu Guillo1Túlio Eduardo Nogueira2Cláudio Rodrigues Leles3Department of Biochemistry and Molecular Biology, Biological Sciences Institute, Federal University of Goias, Avenida Universitária Esquina com 1a Avenida s/n, Setor Universitário, 74605-220 Goiania, GO, BrazilDepartment of Biochemistry and Molecular Biology, Biological Sciences Institute, Federal University of Goias, Avenida Universitária Esquina com 1a Avenida s/n, Setor Universitário, 74605-220 Goiania, GO, BrazilDepartment of Oral Prevention and Rehabilitation, School of Dentistry, Federal University of Goias, Avenida Universitária Esquina com 1a Avenida s/n, Setor Universitário, 74605-220 Goiania, GO, BrazilDepartment of Oral Prevention and Rehabilitation, School of Dentistry, Federal University of Goias, Avenida Universitária Esquina com 1a Avenida s/n, Setor Universitário, 74605-220 Goiania, GO, BrazilObjective. To assess changes in levels of salivary nitric oxide (NO) after insertion of new complete dentures and its association with clinical and salivary parameters. Methods. Nineteen fully edentulous subjects were included, mean age 64.4. Unstimulated whole saliva was collected before and after insertion of the dentures, at follow-up visits, and after 12 months. The concentration of the final stable NO product (nitrite) was measured by a colorimetric assay based on the Griess reaction. Clinical parameters were assessed during all clinical visits. Results. Functional adaptation to the dentures progressively improved, with no complaints at the long-term follow-up. NO concentration was not influenced by the level of functional adaptation, presence of injuries to the mucosa, salivary flow, and saliva viscosity. Pairwise comparison showed a reduction in NO concentration at the first follow-up compared to baseline values but differences were not statistically significant. Significant differences were observed in NO concentrations at the long-term follow-up when compared to the first (p=0.024) and second (p=0.027) visits. Conclusion. NO concentration reduced after denture insertion and returned to baseline levels in the long-term follow-up. This appears to be an autonomic response of the body and provides valuable complementary information for the management of the edentulous patient.http://dx.doi.org/10.1155/2016/8351427 |
| spellingShingle | Maria de Lourdes Breseghelo Lídia Andreu Guillo Túlio Eduardo Nogueira Cláudio Rodrigues Leles Nitric Oxide Concentration and Other Salivary Changes after Insertion of New Complete Dentures in Edentulous Subjects International Journal of Dentistry |
| title | Nitric Oxide Concentration and Other Salivary Changes after Insertion of New Complete Dentures in Edentulous Subjects |
| title_full | Nitric Oxide Concentration and Other Salivary Changes after Insertion of New Complete Dentures in Edentulous Subjects |
| title_fullStr | Nitric Oxide Concentration and Other Salivary Changes after Insertion of New Complete Dentures in Edentulous Subjects |
| title_full_unstemmed | Nitric Oxide Concentration and Other Salivary Changes after Insertion of New Complete Dentures in Edentulous Subjects |
| title_short | Nitric Oxide Concentration and Other Salivary Changes after Insertion of New Complete Dentures in Edentulous Subjects |
| title_sort | nitric oxide concentration and other salivary changes after insertion of new complete dentures in edentulous subjects |
| url | http://dx.doi.org/10.1155/2016/8351427 |
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