Entrectinib can induce nerve cell damage by inhibiting PI3K-AKT and TGF-β signaling pathways

Entrectinib can induce nerve cell damage by inhibiting PI3K-AKT and TGF-β signaling pathways

BackgroundThe tyrosine receptor kinase inhibitor (TRKi) entrectinib is used to treat neurotrophic tyrosine receptor kinase (NTRK) fusion-positive solid tumors and ROS1-positive patients. Despite its impressive efficacy against cancer, the clinical application is still limited by the central nervous...

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Bibliographic Details
Main Authors: Qingshan Tang, Jiachen Dong, Feng Zhang, Dan Zhao, Qi Yang, Jiayu Wen, Yuhao Sun, Jifu Wei, Zhixian Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Pharmacology
Subjects:
entrectinib
nerve cell damage
THBS1
Pi3k-akt
TGF-β
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1489210/full
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