Rapid Detection of Chlorpheniramine Maleate in Human Blood and Urine Samples Based on NiCoP/PVP/PAN/CNFs Electrochemiluminescence Sensor
Chlorpheniramine maleate (CPM) is a first-generation antihistamine that is frequently used to treat allergic reactions. However, excessive consumption presents potential health risks. Therefore, it is crucial to develop a quick and precise technique for identifying CPM levels. In this study, nickel...
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2025-06-01
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| author | Yi Zhang Jiayu Zhao Jiaxing Chen Tingfan Tang Hao Cheng |
| author_facet | Yi Zhang Jiayu Zhao Jiaxing Chen Tingfan Tang Hao Cheng |
| author_sort | Yi Zhang |
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| description | Chlorpheniramine maleate (CPM) is a first-generation antihistamine that is frequently used to treat allergic reactions. However, excessive consumption presents potential health risks. Therefore, it is crucial to develop a quick and precise technique for identifying CPM levels. In this study, nickel cobalt phosphide (NiCoP), a binary metal phosphide, was successfully incorporated into carbon nanofibers. This involved creating a pore structure by adding polyvinylpyrrolidone (PVP) as a pore-forming template to a polyacrylonitrile (PAN) substrate via electrostatic spinning. An innovative electrochemiluminescent sensor for CPM detection was constructed using NiCoP/PVP/PAN carbon nanofibers (NiCoP/PVP/PAN/CNFs). Under optimal conditions, the electrochemical behavior of CPM was studied using NiCoP/PVP/PAN/CNF-modified working electrodes. These findings demonstrate that the three-dimensional porous network architecture of NiCoP/PVP/PAN/CNFs enhances the conductive properties of the material. Consequently, an electrochemical optical sensor fabricated using this structure exhibited remarkable performance. The linear detection range of the sensor was 1 × 10<sup>−8</sup>–7 × 10<sup>−5</sup> mol/L, and the detection limit was 7.8 × 10<sup>−10</sup> mol/L. When human urine and serum samples were examined, the sensor was found to have a high recovery rate (94.35–103.36%), which is promising for practical applications. |
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| institution | Kabale University |
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| spelling | doaj-art-c4e903aecc9f4aed9d8d8d3c46d5ff592025-08-20T03:27:38ZengMDPI AGMolecules1420-30492025-06-013012260310.3390/molecules30122603Rapid Detection of Chlorpheniramine Maleate in Human Blood and Urine Samples Based on NiCoP/PVP/PAN/CNFs Electrochemiluminescence SensorYi Zhang0Jiayu Zhao1Jiaxing Chen2Tingfan Tang3Hao Cheng4School of Biology, Food and Environment, Hefei University, Hefei 230601, ChinaGuangxi Key Laboratory of Green Processing of Sugar Resources, Guangxi Liuzhou Luosifen Research Center of Engineering Technology, College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou 545006, ChinaSchool of Biology, Food and Environment, Hefei University, Hefei 230601, ChinaGuangxi Key Laboratory of Green Processing of Sugar Resources, Guangxi Liuzhou Luosifen Research Center of Engineering Technology, College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou 545006, ChinaGuangxi Key Laboratory of Green Processing of Sugar Resources, Guangxi Liuzhou Luosifen Research Center of Engineering Technology, College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou 545006, ChinaChlorpheniramine maleate (CPM) is a first-generation antihistamine that is frequently used to treat allergic reactions. However, excessive consumption presents potential health risks. Therefore, it is crucial to develop a quick and precise technique for identifying CPM levels. In this study, nickel cobalt phosphide (NiCoP), a binary metal phosphide, was successfully incorporated into carbon nanofibers. This involved creating a pore structure by adding polyvinylpyrrolidone (PVP) as a pore-forming template to a polyacrylonitrile (PAN) substrate via electrostatic spinning. An innovative electrochemiluminescent sensor for CPM detection was constructed using NiCoP/PVP/PAN carbon nanofibers (NiCoP/PVP/PAN/CNFs). Under optimal conditions, the electrochemical behavior of CPM was studied using NiCoP/PVP/PAN/CNF-modified working electrodes. These findings demonstrate that the three-dimensional porous network architecture of NiCoP/PVP/PAN/CNFs enhances the conductive properties of the material. Consequently, an electrochemical optical sensor fabricated using this structure exhibited remarkable performance. The linear detection range of the sensor was 1 × 10<sup>−8</sup>–7 × 10<sup>−5</sup> mol/L, and the detection limit was 7.8 × 10<sup>−10</sup> mol/L. When human urine and serum samples were examined, the sensor was found to have a high recovery rate (94.35–103.36%), which is promising for practical applications.https://www.mdpi.com/1420-3049/30/12/2603electrostatically spun filmporous carbon nanofiberNiCoPpolyacrylonitrileelectrochemiluminescence |
| spellingShingle | Yi Zhang Jiayu Zhao Jiaxing Chen Tingfan Tang Hao Cheng Rapid Detection of Chlorpheniramine Maleate in Human Blood and Urine Samples Based on NiCoP/PVP/PAN/CNFs Electrochemiluminescence Sensor Molecules electrostatically spun film porous carbon nanofiber NiCoP polyacrylonitrile electrochemiluminescence |
| title | Rapid Detection of Chlorpheniramine Maleate in Human Blood and Urine Samples Based on NiCoP/PVP/PAN/CNFs Electrochemiluminescence Sensor |
| title_full | Rapid Detection of Chlorpheniramine Maleate in Human Blood and Urine Samples Based on NiCoP/PVP/PAN/CNFs Electrochemiluminescence Sensor |
| title_fullStr | Rapid Detection of Chlorpheniramine Maleate in Human Blood and Urine Samples Based on NiCoP/PVP/PAN/CNFs Electrochemiluminescence Sensor |
| title_full_unstemmed | Rapid Detection of Chlorpheniramine Maleate in Human Blood and Urine Samples Based on NiCoP/PVP/PAN/CNFs Electrochemiluminescence Sensor |
| title_short | Rapid Detection of Chlorpheniramine Maleate in Human Blood and Urine Samples Based on NiCoP/PVP/PAN/CNFs Electrochemiluminescence Sensor |
| title_sort | rapid detection of chlorpheniramine maleate in human blood and urine samples based on nicop pvp pan cnfs electrochemiluminescence sensor |
| topic | electrostatically spun film porous carbon nanofiber NiCoP polyacrylonitrile electrochemiluminescence |
| url | https://www.mdpi.com/1420-3049/30/12/2603 |
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