Cytohesin-4/ARF6 facilitates the progression of acute myeloid leukemia through activating PIK3R5/PI3K/AKT pathway

Cytohesin-4/ARF6 facilitates the progression of acute myeloid leukemia through activating PIK3R5/PI3K/AKT pathway

Summary: In silico analysis revealed an elevated expression of cytohesin-4 (CYTH4) in acute myeloid leukemia (AML) cells, correlating with a poorer prognosis for AML patients. However, its role in AML is not fully understood. Our study using loss-of-function assays identified CYTH4 as an oncogene pr...

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Main Authors:	Xiao-Fen Qiu, Cheng-Ming He, Yan-Mei Zeng, Xiao-Ling Deng, Guo-Lin Liang, Ming-Xing Zhong, Min Zou, Xiu-Juan Xiong, Jing-Dong Zhang, Yan Ye, Qing Niu, Xiao-Li Chen
Format:	Article
Language:	English
Published:	Elsevier 2025-06-01
Series:	iScience
Subjects:	Cancer Cell biology
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004225008958
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