Preclinical Evidences for an Antimanic Effect of Carvedilol
Oxidative imbalance, alterations in brain-derived neurotrophic factor (BDNF), and mitochondrial dysfunction are implicated in bipolar disorder (BD) pathophysiology and comorbidities, for example, cardiovascular conditions. Carvedilol (CVD), a nonselective beta-blocker widely used for the treatment o...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2015/692541 |
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| author | Greicy Coelho de Souza Julia Ariana de S. Gomes Ana Isabelle de Góis Queiroz Maíra Morais de Araújo Lígia Menezes Cavalcante Michel de Jesus Souza Machado Aline Santos Monte David Freitas de Lucena João Quevedo André Ferrer Carvalho Danielle Macêdo |
| author_facet | Greicy Coelho de Souza Julia Ariana de S. Gomes Ana Isabelle de Góis Queiroz Maíra Morais de Araújo Lígia Menezes Cavalcante Michel de Jesus Souza Machado Aline Santos Monte David Freitas de Lucena João Quevedo André Ferrer Carvalho Danielle Macêdo |
| author_sort | Greicy Coelho de Souza |
| collection | DOAJ |
| description | Oxidative imbalance, alterations in brain-derived neurotrophic factor (BDNF), and mitochondrial dysfunction are implicated in bipolar disorder (BD) pathophysiology and comorbidities, for example, cardiovascular conditions. Carvedilol (CVD), a nonselective beta-blocker widely used for the treatment of hypertension, presents antioxidant and mitochondrial stabilizing properties. Thus, we hypothesized that CVD would prevent and/or reverse mania-like behavioral and neurochemical alterations induced by lisdexamfetamine dimesylate (LDX). To do this, male Wistar rats were submitted to two different protocols, namely, prevention and reversal. In the prevention treatment the rats received daily oral administration (mg/kg) of CVD (2.5, 5 or 7.5), saline, valproate (VAL200), or the combination of CVD5 + VAL100 for 7 days. From the 8th to 14th day LDX was added. In the reversal protocol LDX was administered for 7 days with the drugs being added from the 8th to 14th day of treatment. Two hours after the last administration the behavioral (open field and social interaction) and neurochemical (reduced glutathione, lipid peroxidation, and BDNF) determinations were performed. The results showed that CVD prevented and reversed the behavioral and neurochemical alterations induced by LDX. The administration of CVD5 + VAL100 potentiated the effect of VAL200 alone. Taken together these results demonstrate a possible antimanic effect of CVD in this preclinical model. |
| format | Article |
| id | doaj-art-c4ccf17aaa9046b5a7470e39bcde6cd2 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-c4ccf17aaa9046b5a7470e39bcde6cd22025-02-03T05:53:57ZengWileyNeural Plasticity2090-59041687-54432015-01-01201510.1155/2015/692541692541Preclinical Evidences for an Antimanic Effect of CarvedilolGreicy Coelho de Souza0Julia Ariana de S. Gomes1Ana Isabelle de Góis Queiroz2Maíra Morais de Araújo3Lígia Menezes Cavalcante4Michel de Jesus Souza Machado5Aline Santos Monte6David Freitas de Lucena7João Quevedo8André Ferrer Carvalho9Danielle Macêdo10Neuropharmacology Laboratory, Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Rua Coronel Nunes de Melo 1127, 60431-270 Fortaleza, CE, BrazilNeuropharmacology Laboratory, Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Rua Coronel Nunes de Melo 1127, 60431-270 Fortaleza, CE, BrazilNeuropharmacology Laboratory, Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Rua Coronel Nunes de Melo 1127, 60431-270 Fortaleza, CE, BrazilNeuropharmacology Laboratory, Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Rua Coronel Nunes de Melo 1127, 60431-270 Fortaleza, CE, BrazilNeuropharmacology Laboratory, Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Rua Coronel Nunes de Melo 1127, 60431-270 Fortaleza, CE, BrazilNeuropharmacology Laboratory, Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Rua Coronel Nunes de Melo 1127, 60431-270 Fortaleza, CE, BrazilNeuropharmacology Laboratory, Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Rua Coronel Nunes de Melo 1127, 60431-270 Fortaleza, CE, BrazilNeuropharmacology Laboratory, Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Rua Coronel Nunes de Melo 1127, 60431-270 Fortaleza, CE, BrazilLaboratório de Neurociências, Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, 88806-000 Criciúma, SC, BrazilPsychiatry Research Group, Faculty of Medicine, Federal University of Ceará, 60430-160 Fortaleza, CE, BrazilNeuropharmacology Laboratory, Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Rua Coronel Nunes de Melo 1127, 60431-270 Fortaleza, CE, BrazilOxidative imbalance, alterations in brain-derived neurotrophic factor (BDNF), and mitochondrial dysfunction are implicated in bipolar disorder (BD) pathophysiology and comorbidities, for example, cardiovascular conditions. Carvedilol (CVD), a nonselective beta-blocker widely used for the treatment of hypertension, presents antioxidant and mitochondrial stabilizing properties. Thus, we hypothesized that CVD would prevent and/or reverse mania-like behavioral and neurochemical alterations induced by lisdexamfetamine dimesylate (LDX). To do this, male Wistar rats were submitted to two different protocols, namely, prevention and reversal. In the prevention treatment the rats received daily oral administration (mg/kg) of CVD (2.5, 5 or 7.5), saline, valproate (VAL200), or the combination of CVD5 + VAL100 for 7 days. From the 8th to 14th day LDX was added. In the reversal protocol LDX was administered for 7 days with the drugs being added from the 8th to 14th day of treatment. Two hours after the last administration the behavioral (open field and social interaction) and neurochemical (reduced glutathione, lipid peroxidation, and BDNF) determinations were performed. The results showed that CVD prevented and reversed the behavioral and neurochemical alterations induced by LDX. The administration of CVD5 + VAL100 potentiated the effect of VAL200 alone. Taken together these results demonstrate a possible antimanic effect of CVD in this preclinical model.http://dx.doi.org/10.1155/2015/692541 |
| spellingShingle | Greicy Coelho de Souza Julia Ariana de S. Gomes Ana Isabelle de Góis Queiroz Maíra Morais de Araújo Lígia Menezes Cavalcante Michel de Jesus Souza Machado Aline Santos Monte David Freitas de Lucena João Quevedo André Ferrer Carvalho Danielle Macêdo Preclinical Evidences for an Antimanic Effect of Carvedilol Neural Plasticity |
| title | Preclinical Evidences for an Antimanic Effect of Carvedilol |
| title_full | Preclinical Evidences for an Antimanic Effect of Carvedilol |
| title_fullStr | Preclinical Evidences for an Antimanic Effect of Carvedilol |
| title_full_unstemmed | Preclinical Evidences for an Antimanic Effect of Carvedilol |
| title_short | Preclinical Evidences for an Antimanic Effect of Carvedilol |
| title_sort | preclinical evidences for an antimanic effect of carvedilol |
| url | http://dx.doi.org/10.1155/2015/692541 |
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