Signaling Pathways Involved in Acute Pancreatitis
Mengchen Luo,1,* Ting Jin,1,* Yi Fang,1,* Feng Chen,1 Lujian Zhu,2 Jin Bai,3 Jin Ding1 1Department of Gastroenterology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, People’s Republic of China; 2Department of Infectious Diseases, Affiliated Jinhu...
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Dove Medical Press
2025-02-01
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| Series: | Journal of Inflammation Research |
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| Online Access: | https://www.dovepress.com/signaling-pathways-involved-in-acute-pancreatitis-peer-reviewed-fulltext-article-JIR |
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| author | Luo M Jin T Fang Y Chen F Zhu L Bai J Ding J |
| author_facet | Luo M Jin T Fang Y Chen F Zhu L Bai J Ding J |
| author_sort | Luo M |
| collection | DOAJ |
| description | Mengchen Luo,1,* Ting Jin,1,* Yi Fang,1,* Feng Chen,1 Lujian Zhu,2 Jin Bai,3 Jin Ding1 1Department of Gastroenterology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, People’s Republic of China; 2Department of Infectious Diseases, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, People’s Republic of China; 3Cancer Institute, Xuzhou Medical University, Xuzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jin Bai, Cancer Institute, Xuzhou Medical University, Xuzhou, People’s Republic of China, Email bj@xzhmu.edu.cn Jin Ding, Department of Gastroenterology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, People’s Republic of China, Email jhDingJin@zju.edu.cnAbstract: Acute pancreatitis (AP) is a common digestive emergency with high morbidity and mortality. Over the past decade, significant progress has been made in understanding the mechanisms of AP, including oxidative stress, disruptions in calcium homeostasis, endoplasmic reticulum stress, inflammatory responses, and various forms of cell death. This review provides an overview of the typical signaling pathways involved and proposes the latest clinical translation prospects. These strategies are important for the early management of AP, preventing multi-organ injury, and improving the overall prognosis of the disease.Keywords: acute pancreatitis, signaling pathway, calcium overload, endoplasmic reticulum stress, cell death |
| format | Article |
| id | doaj-art-c4bb55a7051a4b1a8761df815f51a88b |
| institution | OA Journals |
| issn | 1178-7031 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Inflammation Research |
| spelling | doaj-art-c4bb55a7051a4b1a8761df815f51a88b2025-08-20T02:13:24ZengDove Medical PressJournal of Inflammation Research1178-70312025-02-01Volume 1822872303100242Signaling Pathways Involved in Acute PancreatitisLuo MJin TFang YChen FZhu LBai JDing JMengchen Luo,1,* Ting Jin,1,* Yi Fang,1,* Feng Chen,1 Lujian Zhu,2 Jin Bai,3 Jin Ding1 1Department of Gastroenterology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, People’s Republic of China; 2Department of Infectious Diseases, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, People’s Republic of China; 3Cancer Institute, Xuzhou Medical University, Xuzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jin Bai, Cancer Institute, Xuzhou Medical University, Xuzhou, People’s Republic of China, Email bj@xzhmu.edu.cn Jin Ding, Department of Gastroenterology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, People’s Republic of China, Email jhDingJin@zju.edu.cnAbstract: Acute pancreatitis (AP) is a common digestive emergency with high morbidity and mortality. Over the past decade, significant progress has been made in understanding the mechanisms of AP, including oxidative stress, disruptions in calcium homeostasis, endoplasmic reticulum stress, inflammatory responses, and various forms of cell death. This review provides an overview of the typical signaling pathways involved and proposes the latest clinical translation prospects. These strategies are important for the early management of AP, preventing multi-organ injury, and improving the overall prognosis of the disease.Keywords: acute pancreatitis, signaling pathway, calcium overload, endoplasmic reticulum stress, cell deathhttps://www.dovepress.com/signaling-pathways-involved-in-acute-pancreatitis-peer-reviewed-fulltext-article-JIRacute pancreatitissignaling pathwaycalcium overloadendoplasmic reticulum stresscell death |
| spellingShingle | Luo M Jin T Fang Y Chen F Zhu L Bai J Ding J Signaling Pathways Involved in Acute Pancreatitis Journal of Inflammation Research acute pancreatitis signaling pathway calcium overload endoplasmic reticulum stress cell death |
| title | Signaling Pathways Involved in Acute Pancreatitis |
| title_full | Signaling Pathways Involved in Acute Pancreatitis |
| title_fullStr | Signaling Pathways Involved in Acute Pancreatitis |
| title_full_unstemmed | Signaling Pathways Involved in Acute Pancreatitis |
| title_short | Signaling Pathways Involved in Acute Pancreatitis |
| title_sort | signaling pathways involved in acute pancreatitis |
| topic | acute pancreatitis signaling pathway calcium overload endoplasmic reticulum stress cell death |
| url | https://www.dovepress.com/signaling-pathways-involved-in-acute-pancreatitis-peer-reviewed-fulltext-article-JIR |
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