What is the Helicobacter pylori Global Reinfection Rate?
Reinfection with any organism is related to the force of infection in the population and on both innate and acquired immunity to infection. Little is yet known about primary immune protection against Helicobacter pylori. Some data suggest that children can be recurrently infected, spontaneously elim...
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| Main Author: | |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2003-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2003/567816 |
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| Summary: | Reinfection with any organism is related to the force of infection in the
population and on both innate and acquired immunity to infection.
Little is yet known about primary immune protection against
Helicobacter pylori. Some data suggest that children can be recurrently
infected, spontaneously eliminating the organism only to be infected
again and again until the organism takes hold. This pattern of recurrent
infection is not observed in patients who receive eradication therapy for
chronic infection. After eradication of infection, the rate of reinfection
is probably slightly lower than the primary infection rate in that age
group, suggesting some level of acquired immunity. In developed countries,
reinfection of adults in unusual, and recurrence usually repesents
failure of primary eradicaton rather than new infection. Some cases of
reinfection do occur, however. Given that acquired immunity probably
varies little from population to population, reinfections will most likely
occur in areas where the force of infecton is high, ie, where both the
prevalence of infection and the opportunities for transmission are high. |
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| ISSN: | 0835-7900 |