Correlation between Imaging Morphological Findings and Laboratory Biomarkers in Patients with Diabetic Macular Edema
Purpose. To investigate the potential association between peripheral blood biomarkers and morphological characteristics of retinal imaging in patients with diabetic macular edema (DME). Methods. Participants in this cross-sectional study were 36 consecutive patients (36 eyes) with treatment-naïve DM...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2021/6426003 |
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| author | Eleni Dimitriou Theodoros N. Sergentanis Vaia Lambadiari George Theodossiadis Panagiotis Theodossiadis Irini Chatziralli |
| author_facet | Eleni Dimitriou Theodoros N. Sergentanis Vaia Lambadiari George Theodossiadis Panagiotis Theodossiadis Irini Chatziralli |
| author_sort | Eleni Dimitriou |
| collection | DOAJ |
| description | Purpose. To investigate the potential association between peripheral blood biomarkers and morphological characteristics of retinal imaging in patients with diabetic macular edema (DME). Methods. Participants in this cross-sectional study were 36 consecutive patients (36 eyes) with treatment-naïve DME, who underwent spectral domain-optical coherence tomography (SD-OCT), fundus photography, and fundus fluorescein angiography (FFA). In addition, peripheral blood samples were taken to evaluate full blood count and biochemical parameters. Correlation between imaging characteristics and laboratory parameters was examined. Results. Eyes with central subfield thickness greater than 405 μm presented significantly higher neutrophils/lymphocytes (p=0.043) and higher lipoprotein (a) compared to eyes with CST<405 μm (p=0.003). Presence of hyperreflective foci on SD-OCT was associated with significantly higher white blood cell count (p=0.028). Ellipsoid zone disruption was associated with significantly lower hematocrit (p=0.012), hemoglobin (p=0.009), and red blood cell count (p=0.026), as well as with higher lipoprotein (a) (p=0.015). Macular ischemia on FFA was associated with significantly higher monocytes (p=0.027) and monocytes/HDL (p=0.019). No significant associations were found between laboratory parameters and subretinal fluid, intraretinal fluid, exudates, cysts, disorganization of inner retinal layers, epiretinal membrane, and external limiting membrane condition. Conclusion. Specific imaging morphological characteristics were found to be associated with laboratory parameters in patients with DME. These findings may shed light on the pathophysiology of DME and its correlation with the development of specific clinical signs. |
| format | Article |
| id | doaj-art-c4af8342f82c4494a505b77c973ff583 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-c4af8342f82c4494a505b77c973ff5832025-02-03T01:25:08ZengWileyJournal of Diabetes Research2314-67452314-67532021-01-01202110.1155/2021/64260036426003Correlation between Imaging Morphological Findings and Laboratory Biomarkers in Patients with Diabetic Macular EdemaEleni Dimitriou0Theodoros N. Sergentanis1Vaia Lambadiari2George Theodossiadis3Panagiotis Theodossiadis4Irini Chatziralli52nd Department of Ophthalmology, National and Kapodistrian University of Athens, Athens, GreeceDepartment of Clinical Therapeutics, Alexandra Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece2nd Department of Internal Medicine, Research Institute and Diabetes Center, National and Kapodistrian University of Athens, Athens, Greece2nd Department of Ophthalmology, National and Kapodistrian University of Athens, Athens, Greece2nd Department of Ophthalmology, National and Kapodistrian University of Athens, Athens, Greece2nd Department of Ophthalmology, National and Kapodistrian University of Athens, Athens, GreecePurpose. To investigate the potential association between peripheral blood biomarkers and morphological characteristics of retinal imaging in patients with diabetic macular edema (DME). Methods. Participants in this cross-sectional study were 36 consecutive patients (36 eyes) with treatment-naïve DME, who underwent spectral domain-optical coherence tomography (SD-OCT), fundus photography, and fundus fluorescein angiography (FFA). In addition, peripheral blood samples were taken to evaluate full blood count and biochemical parameters. Correlation between imaging characteristics and laboratory parameters was examined. Results. Eyes with central subfield thickness greater than 405 μm presented significantly higher neutrophils/lymphocytes (p=0.043) and higher lipoprotein (a) compared to eyes with CST<405 μm (p=0.003). Presence of hyperreflective foci on SD-OCT was associated with significantly higher white blood cell count (p=0.028). Ellipsoid zone disruption was associated with significantly lower hematocrit (p=0.012), hemoglobin (p=0.009), and red blood cell count (p=0.026), as well as with higher lipoprotein (a) (p=0.015). Macular ischemia on FFA was associated with significantly higher monocytes (p=0.027) and monocytes/HDL (p=0.019). No significant associations were found between laboratory parameters and subretinal fluid, intraretinal fluid, exudates, cysts, disorganization of inner retinal layers, epiretinal membrane, and external limiting membrane condition. Conclusion. Specific imaging morphological characteristics were found to be associated with laboratory parameters in patients with DME. These findings may shed light on the pathophysiology of DME and its correlation with the development of specific clinical signs.http://dx.doi.org/10.1155/2021/6426003 |
| spellingShingle | Eleni Dimitriou Theodoros N. Sergentanis Vaia Lambadiari George Theodossiadis Panagiotis Theodossiadis Irini Chatziralli Correlation between Imaging Morphological Findings and Laboratory Biomarkers in Patients with Diabetic Macular Edema Journal of Diabetes Research |
| title | Correlation between Imaging Morphological Findings and Laboratory Biomarkers in Patients with Diabetic Macular Edema |
| title_full | Correlation between Imaging Morphological Findings and Laboratory Biomarkers in Patients with Diabetic Macular Edema |
| title_fullStr | Correlation between Imaging Morphological Findings and Laboratory Biomarkers in Patients with Diabetic Macular Edema |
| title_full_unstemmed | Correlation between Imaging Morphological Findings and Laboratory Biomarkers in Patients with Diabetic Macular Edema |
| title_short | Correlation between Imaging Morphological Findings and Laboratory Biomarkers in Patients with Diabetic Macular Edema |
| title_sort | correlation between imaging morphological findings and laboratory biomarkers in patients with diabetic macular edema |
| url | http://dx.doi.org/10.1155/2021/6426003 |
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