On the Dual Role of Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) in Human Malignancies
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a glycoprotein belonging to the carcinoembryonic antigen (CEA) family that is expressed on a wide variety of cells and holds a complex role in inflammation through its alternate splicing and generation of various isoforms, mediat...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/7169081 |
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| author | Andreea Calinescu Gabriela Turcu Roxana I. Nedelcu Alice Brinzea Anastasia Hodorogea Mihaela Antohe Carmen Diaconu Coralia Bleotu Daniel Pirici Lucia B. Jilaveanu Daniela A. Ion Ioana A. Badarau |
| author_facet | Andreea Calinescu Gabriela Turcu Roxana I. Nedelcu Alice Brinzea Anastasia Hodorogea Mihaela Antohe Carmen Diaconu Coralia Bleotu Daniel Pirici Lucia B. Jilaveanu Daniela A. Ion Ioana A. Badarau |
| author_sort | Andreea Calinescu |
| collection | DOAJ |
| description | Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a glycoprotein belonging to the carcinoembryonic antigen (CEA) family that is expressed on a wide variety of cells and holds a complex role in inflammation through its alternate splicing and generation of various isoforms, mediating intricate mechanisms of modulation and dysregulation. Initially regarded as a tumor suppressor as its expression shows considerable downregulation within the epithelia in the early phases of many solid cancers, CEACAM1 has been linked lately to the progression of malignancy and metastatic spread as various papers point to its role in tumor progression, angiogenesis, and invasion. We reviewed the literature and discussed the various expression patterns of CEACAM1 in different types of tumors, describing its structure and general biologic functions and emphasizing the most significant findings that link this molecule to poor prognosis. The importance of understanding the role of CEACAM1 in cell transformation stands not only in this adhesion molecule’s value as a prognostic factor but also in its promising premise as a potential new molecular target that could be exploited as a specific cancer therapy. |
| format | Article |
| id | doaj-art-c4a5904c91494aa3888c8e1ba2f53b94 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-c4a5904c91494aa3888c8e1ba2f53b942025-02-03T01:27:26ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/71690817169081On the Dual Role of Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) in Human MalignanciesAndreea Calinescu0Gabriela Turcu1Roxana I. Nedelcu2Alice Brinzea3Anastasia Hodorogea4Mihaela Antohe5Carmen Diaconu6Coralia Bleotu7Daniel Pirici8Lucia B. Jilaveanu9Daniela A. Ion10Ioana A. Badarau11Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaCarol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaCarol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaCarol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaCarol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaCarol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaStefan Nicolau Institute of Virology, 030304 Bucharest, RomaniaStefan Nicolau Institute of Virology, 030304 Bucharest, RomaniaUniversity of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Medicine, Section of Medical Oncology, Yale University School of Medicine, New Haven, CT 208028, USACarol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaCarol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaCarcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a glycoprotein belonging to the carcinoembryonic antigen (CEA) family that is expressed on a wide variety of cells and holds a complex role in inflammation through its alternate splicing and generation of various isoforms, mediating intricate mechanisms of modulation and dysregulation. Initially regarded as a tumor suppressor as its expression shows considerable downregulation within the epithelia in the early phases of many solid cancers, CEACAM1 has been linked lately to the progression of malignancy and metastatic spread as various papers point to its role in tumor progression, angiogenesis, and invasion. We reviewed the literature and discussed the various expression patterns of CEACAM1 in different types of tumors, describing its structure and general biologic functions and emphasizing the most significant findings that link this molecule to poor prognosis. The importance of understanding the role of CEACAM1 in cell transformation stands not only in this adhesion molecule’s value as a prognostic factor but also in its promising premise as a potential new molecular target that could be exploited as a specific cancer therapy.http://dx.doi.org/10.1155/2018/7169081 |
| spellingShingle | Andreea Calinescu Gabriela Turcu Roxana I. Nedelcu Alice Brinzea Anastasia Hodorogea Mihaela Antohe Carmen Diaconu Coralia Bleotu Daniel Pirici Lucia B. Jilaveanu Daniela A. Ion Ioana A. Badarau On the Dual Role of Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) in Human Malignancies Journal of Immunology Research |
| title | On the Dual Role of Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) in Human Malignancies |
| title_full | On the Dual Role of Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) in Human Malignancies |
| title_fullStr | On the Dual Role of Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) in Human Malignancies |
| title_full_unstemmed | On the Dual Role of Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) in Human Malignancies |
| title_short | On the Dual Role of Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) in Human Malignancies |
| title_sort | on the dual role of carcinoembryonic antigen related cell adhesion molecule 1 ceacam1 in human malignancies |
| url | http://dx.doi.org/10.1155/2018/7169081 |
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