The Potential Application of Nanocarriers in Delivering Topical Antioxidants
The imbalance in the production of reactive oxygen species (ROS) with endogenous antioxidant capacity leads to oxidative stress, which drives many disorders, especially in the skin. In such conditions, supplementing exogenous antioxidants may help the body prevent the negative effect of ROS. However...
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| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/18/1/56 |
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| author | Zulfan Zazuli Rika Hartati Cornelia Rosasepti Rowa Sukmadjaja Asyarie Satrialdi |
| author_facet | Zulfan Zazuli Rika Hartati Cornelia Rosasepti Rowa Sukmadjaja Asyarie Satrialdi |
| author_sort | Zulfan Zazuli |
| collection | DOAJ |
| description | The imbalance in the production of reactive oxygen species (ROS) with endogenous antioxidant capacity leads to oxidative stress, which drives many disorders, especially in the skin. In such conditions, supplementing exogenous antioxidants may help the body prevent the negative effect of ROS. However, the skin, as the outermost barrier of the body, provides a perfect barricade, making the antioxidant delivery complicated. Several strategies have been developed to enhance the penetration of antioxidants through the skin, one of which is nanotechnology. This review focuses on utilizing several nanocarrier systems, including nanoemulsions, liposomes, solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), and polymeric nanoparticles, for transporting antioxidants into the skin. We also reveal ROS formation in the skin and the role of antioxidant therapy, as well as the natural sources of antioxidants. Furthermore, we discuss the clinical application of topical antioxidant therapy concomitantly with the current status of using nanotechnology to deliver topical antioxidants. This review will accelerate the advancement of topical antioxidant therapy. |
| format | Article |
| id | doaj-art-c4a4c4c20f0d4fe5b025766ec8042353 |
| institution | Kabale University |
| issn | 1424-8247 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj-art-c4a4c4c20f0d4fe5b025766ec80423532025-01-24T13:45:13ZengMDPI AGPharmaceuticals1424-82472025-01-011815610.3390/ph18010056The Potential Application of Nanocarriers in Delivering Topical AntioxidantsZulfan Zazuli0Rika Hartati1Cornelia Rosasepti Rowa2Sukmadjaja Asyarie3Satrialdi4Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, Institut Teknologi Bandung, Bandung 40132, IndonesiaDepartment of Pharmaceutical Biology, School of Pharmacy, Institut Teknologi Bandung, Bandung 40132, IndonesiaDepartment of Pharmaceutics, School of Pharmacy, Institut Teknologi Bandung, Bandung 40132, IndonesiaDepartment of Pharmaceutics, School of Pharmacy, Institut Teknologi Bandung, Bandung 40132, IndonesiaDepartment of Pharmaceutics, School of Pharmacy, Institut Teknologi Bandung, Bandung 40132, IndonesiaThe imbalance in the production of reactive oxygen species (ROS) with endogenous antioxidant capacity leads to oxidative stress, which drives many disorders, especially in the skin. In such conditions, supplementing exogenous antioxidants may help the body prevent the negative effect of ROS. However, the skin, as the outermost barrier of the body, provides a perfect barricade, making the antioxidant delivery complicated. Several strategies have been developed to enhance the penetration of antioxidants through the skin, one of which is nanotechnology. This review focuses on utilizing several nanocarrier systems, including nanoemulsions, liposomes, solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), and polymeric nanoparticles, for transporting antioxidants into the skin. We also reveal ROS formation in the skin and the role of antioxidant therapy, as well as the natural sources of antioxidants. Furthermore, we discuss the clinical application of topical antioxidant therapy concomitantly with the current status of using nanotechnology to deliver topical antioxidants. This review will accelerate the advancement of topical antioxidant therapy.https://www.mdpi.com/1424-8247/18/1/56nanocarriersantioxidantstopicalnatural antioxidants |
| spellingShingle | Zulfan Zazuli Rika Hartati Cornelia Rosasepti Rowa Sukmadjaja Asyarie Satrialdi The Potential Application of Nanocarriers in Delivering Topical Antioxidants Pharmaceuticals nanocarriers antioxidants topical natural antioxidants |
| title | The Potential Application of Nanocarriers in Delivering Topical Antioxidants |
| title_full | The Potential Application of Nanocarriers in Delivering Topical Antioxidants |
| title_fullStr | The Potential Application of Nanocarriers in Delivering Topical Antioxidants |
| title_full_unstemmed | The Potential Application of Nanocarriers in Delivering Topical Antioxidants |
| title_short | The Potential Application of Nanocarriers in Delivering Topical Antioxidants |
| title_sort | potential application of nanocarriers in delivering topical antioxidants |
| topic | nanocarriers antioxidants topical natural antioxidants |
| url | https://www.mdpi.com/1424-8247/18/1/56 |
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