Aliskiren Reduces the Adrenal Zona Glomerulosa Apoptosis and Autophagy in Wistar Rats with 2K1C Hypertension
Hypertension is a disease classified as primary or secondary, manifested not only by elevation of blood pressure but also involved in structural and functional changes of target organs. Renal artery stenosis is a leading factor of secondary hypertension, and its progress is associated with overactiv...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2020/7684849 |
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| author | Veronica S. de Matos Ana L. R. do Nascimento Priscila G. Pereira Kíssila Rabelo Cherley B. V. Andrade Alan C. N. Moraes Camila Salata Victor H. V. de O. Araújo Bianca Torres Ciambarella Aline Bonfim Vieira Luciana Lontro Alves Jemima F. R. da Silva Jorge J. de Carvalho |
| author_facet | Veronica S. de Matos Ana L. R. do Nascimento Priscila G. Pereira Kíssila Rabelo Cherley B. V. Andrade Alan C. N. Moraes Camila Salata Victor H. V. de O. Araújo Bianca Torres Ciambarella Aline Bonfim Vieira Luciana Lontro Alves Jemima F. R. da Silva Jorge J. de Carvalho |
| author_sort | Veronica S. de Matos |
| collection | DOAJ |
| description | Hypertension is a disease classified as primary or secondary, manifested not only by elevation of blood pressure but also involved in structural and functional changes of target organs. Renal artery stenosis is a leading factor of secondary hypertension, and its progress is associated with overactivation of the renin-angiotensin-aldosterone system (RAAS). Aliskiren is a renin inhibiting drug that suppresses RAAS and culminates in decreased renin release, plasma angiotensin II concentration, and inhibition of aldosterone secretion. In this sense, the aim of the present study was to analyze the structural and ultrastructural morphophysiology of the adrenal glomerular zone, after treatment with aliskiren in Wistar rats with 2K1C hypertension. Parameters as structure and ultrastructure of the adrenal glomerular zone, cellular apoptosis, nuclear cell proliferation, and AT1 receptor expression were analyzed by immunostaining and electron microscopy. Our results showed that the hypertensive animals treated with aliskiren presented a reestablishment of AT1 receptor expression and decrease in apoptosis and autophagy. In addition, treatment with aliskiren improves the cell aspects in the adrenal glomerular zone, evidenced by ultrastructural analysis through preserved nuclei and well-developed mitochondria. Therefore, our evidence suggests that aliskiren has a beneficial effect on the adrenal glomerular zone remodeling in animals with renovascular hypertension. |
| format | Article |
| id | doaj-art-c4a31d0d8e4e4595a973fed8f4e3bf18 |
| institution | OA Journals |
| issn | 2090-0384 2090-0392 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-c4a31d0d8e4e4595a973fed8f4e3bf182025-08-20T02:18:46ZengWileyInternational Journal of Hypertension2090-03842090-03922020-01-01202010.1155/2020/76848497684849Aliskiren Reduces the Adrenal Zona Glomerulosa Apoptosis and Autophagy in Wistar Rats with 2K1C HypertensionVeronica S. de Matos0Ana L. R. do Nascimento1Priscila G. Pereira2Kíssila Rabelo3Cherley B. V. Andrade4Alan C. N. Moraes5Camila Salata6Victor H. V. de O. Araújo7Bianca Torres Ciambarella8Aline Bonfim Vieira9Luciana Lontro Alves10Jemima F. R. da Silva11Jorge J. de Carvalho12Laboratory of Ultrastructure and Tecidual Biology, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, BrazilLaboratory of Ultrastructure and Tecidual Biology, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, BrazilLaboratory of Ultrastructure and Tecidual Biology, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, BrazilLaboratory of Ultrastructure and Tecidual Biology, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, BrazilTranslational Endocrinology Laboratory, Institute of Biophysics Carlos Chagas Filho, Health Sciences Center, UFRJ, Rio de Janeiro, BrazilInstitute of Biology, UFF, Rio de Janeiro, RJ, BrazilLaboratory of Ultrastructure and Tecidual Biology, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, BrazilLaboratory of Ultrastructure and Tecidual Biology, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, BrazilLaboratory of Ultrastructure and Tecidual Biology, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, BrazilRoss University School of Veterinary Medicine, Biomedical Department, Basseterre, Saint Kitts and NevisLaboratory of Ultrastructure and Tecidual Biology, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, BrazilLaboratory of Ultrastructure and Tecidual Biology, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, BrazilLaboratory of Ultrastructure and Tecidual Biology, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, BrazilHypertension is a disease classified as primary or secondary, manifested not only by elevation of blood pressure but also involved in structural and functional changes of target organs. Renal artery stenosis is a leading factor of secondary hypertension, and its progress is associated with overactivation of the renin-angiotensin-aldosterone system (RAAS). Aliskiren is a renin inhibiting drug that suppresses RAAS and culminates in decreased renin release, plasma angiotensin II concentration, and inhibition of aldosterone secretion. In this sense, the aim of the present study was to analyze the structural and ultrastructural morphophysiology of the adrenal glomerular zone, after treatment with aliskiren in Wistar rats with 2K1C hypertension. Parameters as structure and ultrastructure of the adrenal glomerular zone, cellular apoptosis, nuclear cell proliferation, and AT1 receptor expression were analyzed by immunostaining and electron microscopy. Our results showed that the hypertensive animals treated with aliskiren presented a reestablishment of AT1 receptor expression and decrease in apoptosis and autophagy. In addition, treatment with aliskiren improves the cell aspects in the adrenal glomerular zone, evidenced by ultrastructural analysis through preserved nuclei and well-developed mitochondria. Therefore, our evidence suggests that aliskiren has a beneficial effect on the adrenal glomerular zone remodeling in animals with renovascular hypertension.http://dx.doi.org/10.1155/2020/7684849 |
| spellingShingle | Veronica S. de Matos Ana L. R. do Nascimento Priscila G. Pereira Kíssila Rabelo Cherley B. V. Andrade Alan C. N. Moraes Camila Salata Victor H. V. de O. Araújo Bianca Torres Ciambarella Aline Bonfim Vieira Luciana Lontro Alves Jemima F. R. da Silva Jorge J. de Carvalho Aliskiren Reduces the Adrenal Zona Glomerulosa Apoptosis and Autophagy in Wistar Rats with 2K1C Hypertension International Journal of Hypertension |
| title | Aliskiren Reduces the Adrenal Zona Glomerulosa Apoptosis and Autophagy in Wistar Rats with 2K1C Hypertension |
| title_full | Aliskiren Reduces the Adrenal Zona Glomerulosa Apoptosis and Autophagy in Wistar Rats with 2K1C Hypertension |
| title_fullStr | Aliskiren Reduces the Adrenal Zona Glomerulosa Apoptosis and Autophagy in Wistar Rats with 2K1C Hypertension |
| title_full_unstemmed | Aliskiren Reduces the Adrenal Zona Glomerulosa Apoptosis and Autophagy in Wistar Rats with 2K1C Hypertension |
| title_short | Aliskiren Reduces the Adrenal Zona Glomerulosa Apoptosis and Autophagy in Wistar Rats with 2K1C Hypertension |
| title_sort | aliskiren reduces the adrenal zona glomerulosa apoptosis and autophagy in wistar rats with 2k1c hypertension |
| url | http://dx.doi.org/10.1155/2020/7684849 |
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