Preliminary Report on the Effect of Ketamine in Patients with Central Pain
This preliminary open prospective study reports on the effect of ketamine, an N-methyl-D-aspartate (NMDA)-receptor noncompetitive antagonist, in five patients suffering from central poststroke pain (CPSP). Patients were evaluated at rest on a visual analogue scale (VAS) graded from 0 to 10. Pain mea...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
1997-01-01
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| Series: | Pain Research and Management |
| Online Access: | http://dx.doi.org/10.1155/1997/523784 |
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| _version_ | 1832567402379870208 |
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| author | Sylvie Rostaing-Rigatti Pierre Cesaro Jean-Paul N’Guyen Jean-François Ejzenbaum Bernard Pollin Francis Bonnet |
| author_facet | Sylvie Rostaing-Rigatti Pierre Cesaro Jean-Paul N’Guyen Jean-François Ejzenbaum Bernard Pollin Francis Bonnet |
| author_sort | Sylvie Rostaing-Rigatti |
| collection | DOAJ |
| description | This preliminary open prospective study reports on the effect of ketamine, an N-methyl-D-aspartate (NMDA)-receptor noncompetitive antagonist, in five patients suffering from central poststroke pain (CPSP). Patients were evaluated at rest on a visual analogue scale (VAS) graded from 0 to 10. Pain measurement was repeated at 15 and 30 mins following intravenous administration of 0.15 to 0.25 mg/kg ketamine and then every 30 mins for 6 h. Pain evoked by light touch or cold stimulation was also measured in three patients at those times. Patients were monitored for arterial pressure, heart rate, sedation and side effects during the study. Ketamine provided a significant improvement in pain at rest and in evoked pain. A 51% to 84% decrease in the VAS score for pain at rest was observed within 60 to 180 mins. Satisfactory pain relief (more than 50% decrease in the VAS score) lasted for 150 to 210 mins. Two patients had a prolonged improvement over two or three days. Arterial pressure and heart rate did not change significantly. Mild or moderate sedation was noticed in all patients for 20 to 30 mins. These results suggest that blockade of NMDA receptors may provide pain relief in patients suffering from CPSP. |
| format | Article |
| id | doaj-art-c4a2864ae17b41f6a49ce55904fc0a4c |
| institution | Kabale University |
| issn | 1203-6765 |
| language | English |
| publishDate | 1997-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pain Research and Management |
| spelling | doaj-art-c4a2864ae17b41f6a49ce55904fc0a4c2025-02-03T01:01:34ZengWileyPain Research and Management1203-67651997-01-01229510010.1155/1997/523784Preliminary Report on the Effect of Ketamine in Patients with Central PainSylvie Rostaing-Rigatti0Pierre Cesaro1Jean-Paul N’Guyen2Jean-François Ejzenbaum3Bernard Pollin4Francis Bonnet5Département d’Anesthésie-Réanimation, Service de Neurologie, Service de Neurochirurgie, Hôpital Henri Mondor, FranceINSERM U421, Faculté de Médecine, Cedex, FranceDépartement d’Anesthésie-Réanimation, Service de Neurologie, Service de Neurochirurgie, Hôpital Henri Mondor, FranceDépartement d’Anesthésie-Réanimation, Service de Neurologie, Service de Neurochirurgie, Hôpital Henri Mondor, FranceLaboratoire de physiologie de la Manducation, Université Paris VII, Paris, FranceDépartement d’Anesthésie-Réanimation, Service de Neurologie, Service de Neurochirurgie, Hôpital Henri Mondor, FranceThis preliminary open prospective study reports on the effect of ketamine, an N-methyl-D-aspartate (NMDA)-receptor noncompetitive antagonist, in five patients suffering from central poststroke pain (CPSP). Patients were evaluated at rest on a visual analogue scale (VAS) graded from 0 to 10. Pain measurement was repeated at 15 and 30 mins following intravenous administration of 0.15 to 0.25 mg/kg ketamine and then every 30 mins for 6 h. Pain evoked by light touch or cold stimulation was also measured in three patients at those times. Patients were monitored for arterial pressure, heart rate, sedation and side effects during the study. Ketamine provided a significant improvement in pain at rest and in evoked pain. A 51% to 84% decrease in the VAS score for pain at rest was observed within 60 to 180 mins. Satisfactory pain relief (more than 50% decrease in the VAS score) lasted for 150 to 210 mins. Two patients had a prolonged improvement over two or three days. Arterial pressure and heart rate did not change significantly. Mild or moderate sedation was noticed in all patients for 20 to 30 mins. These results suggest that blockade of NMDA receptors may provide pain relief in patients suffering from CPSP.http://dx.doi.org/10.1155/1997/523784 |
| spellingShingle | Sylvie Rostaing-Rigatti Pierre Cesaro Jean-Paul N’Guyen Jean-François Ejzenbaum Bernard Pollin Francis Bonnet Preliminary Report on the Effect of Ketamine in Patients with Central Pain Pain Research and Management |
| title | Preliminary Report on the Effect of Ketamine in Patients with Central Pain |
| title_full | Preliminary Report on the Effect of Ketamine in Patients with Central Pain |
| title_fullStr | Preliminary Report on the Effect of Ketamine in Patients with Central Pain |
| title_full_unstemmed | Preliminary Report on the Effect of Ketamine in Patients with Central Pain |
| title_short | Preliminary Report on the Effect of Ketamine in Patients with Central Pain |
| title_sort | preliminary report on the effect of ketamine in patients with central pain |
| url | http://dx.doi.org/10.1155/1997/523784 |
| work_keys_str_mv | AT sylvierostaingrigatti preliminaryreportontheeffectofketamineinpatientswithcentralpain AT pierrecesaro preliminaryreportontheeffectofketamineinpatientswithcentralpain AT jeanpaulnguyen preliminaryreportontheeffectofketamineinpatientswithcentralpain AT jeanfrancoisejzenbaum preliminaryreportontheeffectofketamineinpatientswithcentralpain AT bernardpollin preliminaryreportontheeffectofketamineinpatientswithcentralpain AT francisbonnet preliminaryreportontheeffectofketamineinpatientswithcentralpain |