Bisphosphonate-Related Osteonecrosis of the Jaw: A Review of the Literature
Bisphosphonates (BPs) are a class of drugs used to treat osteoporosis and malignant bone metastasis. BPs show high binding capacity to the bone matrix, especially in sites of active bone metabolism. The American Society for Bone and Mineral Research defines BRONJ as “an area of exposed bone in the m...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | International Journal of Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2014/192320 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832552182726000640 |
|---|---|
| author | Eder Alberto Sigua-Rodriguez Renato da Costa Ribeiro Ana Caroline Ramos de Brito Natalia Alvarez-Pinzon José Ricardo de Albergaria-Barbosa |
| author_facet | Eder Alberto Sigua-Rodriguez Renato da Costa Ribeiro Ana Caroline Ramos de Brito Natalia Alvarez-Pinzon José Ricardo de Albergaria-Barbosa |
| author_sort | Eder Alberto Sigua-Rodriguez |
| collection | DOAJ |
| description | Bisphosphonates (BPs) are a class of drugs used to treat osteoporosis and malignant bone metastasis. BPs show high binding capacity to the bone matrix, especially in sites of active bone metabolism. The American Society for Bone and Mineral Research defines BRONJ as “an area of exposed bone in the maxillofacial region that has not healed within 8 weeks after identification by a healthcare provider in a patient who is receiving or has been exposed to a bisphosphonate and has not had radiation therapy to the craniofacial region.” Bisphosphonate-related osteonecrosis of the jaw (BRONJ) can adversely affect quality of life, as it may produce significant morbidity. The American Association of Oral and Maxillofacial Surgeons (AAOMS) considers as vitally important that information on BRONJ be disseminated to other dental and medical specialties. The purpose of this work is to offer a perspective on how dentists should manage patients on BPs, to show the benefits of accurately diagnosing BRONJ, and to present diagnostic aids and treatments strategies for the condition. |
| format | Article |
| id | doaj-art-c4a20cc3d34341e0bd3bdfc759c1d06f |
| institution | Kabale University |
| issn | 1687-8728 1687-8736 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Dentistry |
| spelling | doaj-art-c4a20cc3d34341e0bd3bdfc759c1d06f2025-02-03T05:59:20ZengWileyInternational Journal of Dentistry1687-87281687-87362014-01-01201410.1155/2014/192320192320Bisphosphonate-Related Osteonecrosis of the Jaw: A Review of the LiteratureEder Alberto Sigua-Rodriguez0Renato da Costa Ribeiro1Ana Caroline Ramos de Brito2Natalia Alvarez-Pinzon3José Ricardo de Albergaria-Barbosa4Department of Oral and Maxillofacial Surgery, Piracicaba Dental School, P.O. Box 52, University of Campinas (UNICAMP), 13414-903 Piracicaba, SP, BrazilDepartment of Oral and Maxillofacial Surgery, Piracicaba Dental School, P.O. Box 52, University of Campinas (UNICAMP), 13414-903 Piracicaba, SP, BrazilDepartment of Dental Radiology, Piracicaba Dental School, P.O. Box 52, University of Campinas (UNICAMP), 13414-903 Piracicaba, SP, BrazilDepartment of Prosthesis and Periodontology, Piracicaba Dental School, P.O. Box 52, University of Campinas (UNICAMP), 13414-903 Piracicaba, SP, BrazilDepartment of Oral and Maxillofacial Surgery, Piracicaba Dental School, P.O. Box 52, University of Campinas (UNICAMP), 13414-903 Piracicaba, SP, BrazilBisphosphonates (BPs) are a class of drugs used to treat osteoporosis and malignant bone metastasis. BPs show high binding capacity to the bone matrix, especially in sites of active bone metabolism. The American Society for Bone and Mineral Research defines BRONJ as “an area of exposed bone in the maxillofacial region that has not healed within 8 weeks after identification by a healthcare provider in a patient who is receiving or has been exposed to a bisphosphonate and has not had radiation therapy to the craniofacial region.” Bisphosphonate-related osteonecrosis of the jaw (BRONJ) can adversely affect quality of life, as it may produce significant morbidity. The American Association of Oral and Maxillofacial Surgeons (AAOMS) considers as vitally important that information on BRONJ be disseminated to other dental and medical specialties. The purpose of this work is to offer a perspective on how dentists should manage patients on BPs, to show the benefits of accurately diagnosing BRONJ, and to present diagnostic aids and treatments strategies for the condition.http://dx.doi.org/10.1155/2014/192320 |
| spellingShingle | Eder Alberto Sigua-Rodriguez Renato da Costa Ribeiro Ana Caroline Ramos de Brito Natalia Alvarez-Pinzon José Ricardo de Albergaria-Barbosa Bisphosphonate-Related Osteonecrosis of the Jaw: A Review of the Literature International Journal of Dentistry |
| title | Bisphosphonate-Related Osteonecrosis of the Jaw: A Review of the Literature |
| title_full | Bisphosphonate-Related Osteonecrosis of the Jaw: A Review of the Literature |
| title_fullStr | Bisphosphonate-Related Osteonecrosis of the Jaw: A Review of the Literature |
| title_full_unstemmed | Bisphosphonate-Related Osteonecrosis of the Jaw: A Review of the Literature |
| title_short | Bisphosphonate-Related Osteonecrosis of the Jaw: A Review of the Literature |
| title_sort | bisphosphonate related osteonecrosis of the jaw a review of the literature |
| url | http://dx.doi.org/10.1155/2014/192320 |
| work_keys_str_mv | AT ederalbertosiguarodriguez bisphosphonaterelatedosteonecrosisofthejawareviewoftheliterature AT renatodacostaribeiro bisphosphonaterelatedosteonecrosisofthejawareviewoftheliterature AT anacarolineramosdebrito bisphosphonaterelatedosteonecrosisofthejawareviewoftheliterature AT nataliaalvarezpinzon bisphosphonaterelatedosteonecrosisofthejawareviewoftheliterature AT josericardodealbergariabarbosa bisphosphonaterelatedosteonecrosisofthejawareviewoftheliterature |