Identification of RC3H1 as antiviral host factor binding to the non-structural protein 1 of Influenza A virus via a 3-stage computational pipeline and cell-based analysis

Identification of RC3H1 as antiviral host factor binding to the non-structural protein 1 of Influenza A virus via a 3-stage computational pipeline and cell-based analysis

Abstract To complete its life-cycle in the infected host, Influenza A virus (IAV) hijacks host machineries by expressing multiple viral proteins to bind to specific host proteins. In the era of integrative genomics, there is an opportunity to develop computational techniques to accurately and quickl...

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Bibliographic Details
Main Authors: Swee Teng Teo, Shamima Rashid, Kong Yen Liew, Kah Man Lai, Teng Ann Ng, Jifeng Jiao, Chee Keong Kwoh, Yee-Joo Tan
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Virology Journal
Subjects:
Influenza A virus
RC3H1
NS1
C3H zinc finger protein
Online Access:https://doi.org/10.1186/s12985-025-02746-2
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