The impact of endolymphatic hydrops on wideband acoustic immittance and otoacoustic emissions in guinea pigs
BackgroundInner ear disorders, such as EH, commonly lead to hearing loss and vestibular dysfunction. EH is particularly prevalent in various inner ear diseases, including Meniere’s disease. We aimed to evaluate the effects of EH on WAI and OAEs.ObjectiveThis study explores the potential of wideband...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1444928/full |
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| author | Huan Lin Xuanyi Li Huiying Zhang Yi Mu Xi Wang Naveena Konduru Renlong Ji Wen Liu Wen Liu Wen Liu Zhao Fei Wen Jiang Wen Jiang Wen Jiang Yuehua Qiao Yuehua Qiao Yuehua Qiao |
| author_facet | Huan Lin Xuanyi Li Huiying Zhang Yi Mu Xi Wang Naveena Konduru Renlong Ji Wen Liu Wen Liu Wen Liu Zhao Fei Wen Jiang Wen Jiang Wen Jiang Yuehua Qiao Yuehua Qiao Yuehua Qiao |
| author_sort | Huan Lin |
| collection | DOAJ |
| description | BackgroundInner ear disorders, such as EH, commonly lead to hearing loss and vestibular dysfunction. EH is particularly prevalent in various inner ear diseases, including Meniere’s disease. We aimed to evaluate the effects of EH on WAI and OAEs.ObjectiveThis study explores the potential of wideband acoustic immittance (WAI) and otoacoustic emissions (OAEs) for the early detection of changes in acoustic transmission associated with vasopressin-induced endolymphatic hydrops (EH) in a guinea pig model.MethodsWe induced EH in guinea pigs via daily intraperitoneal injections of arginine vasopressin over 14 consecutive days. Auditory function was assessed using Auditory Brainstem Responses (ABR), while changes in sound energy transmission were measured using WAI and Distortion Products Otoacoustic Emissions (DPOAE).ResultsIncreased ABR thresholds in EH models were statistically significant (p < 0.05). After 14 days of EH induction, absorbance at 1 kHz significantly increased, whereas it significantly decreased at 4 kHz and 6 kHz (p < 0.05). DPOAE measures, both magnitude and phase, showed no significant changes (p > 0.05).ConclusionWAI demonstrates greater sensitivity than DPOAE in the early detection of acoustic transmission alterations in EH models, suggesting its utility as a diagnostic tool in early-stage inner ear disorders. |
| format | Article |
| id | doaj-art-c491495f6faa40f2afc1c133a3f55ef4 |
| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-c491495f6faa40f2afc1c133a3f55ef42025-01-23T14:36:30ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-01-011610.3389/fneur.2025.14449281444928The impact of endolymphatic hydrops on wideband acoustic immittance and otoacoustic emissions in guinea pigsHuan Lin0Xuanyi Li1Huiying Zhang2Yi Mu3Xi Wang4Naveena Konduru5Renlong Ji6Wen Liu7Wen Liu8Wen Liu9Zhao Fei10Wen Jiang11Wen Jiang12Wen Jiang13Yuehua Qiao14Yuehua Qiao15Yuehua Qiao16Jiangsu Auditory Engineering Research Center, The Second College of Clinical Medicine, Xuzhou Medical University, Xuzhou, ChinaENT Department, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, ChinaThe First College of Clinical Medicine, Xuzhou Medical University, Xuzhou, ChinaThe First College of Clinical Medicine, Xuzhou Medical University, Xuzhou, ChinaThe First College of Clinical Medicine, Xuzhou Medical University, Xuzhou, ChinaThe First College of Clinical Medicine, Xuzhou Medical University, Xuzhou, ChinaThe First College of Clinical Medicine, Xuzhou Medical University, Xuzhou, ChinaJiangsu Auditory Engineering Research Center, The Second College of Clinical Medicine, Xuzhou Medical University, Xuzhou, ChinaENT Department, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, ChinaThe First College of Clinical Medicine, Xuzhou Medical University, Xuzhou, ChinaCentre for SLT and Hearing Sciences, Cardiff School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, United KingdomJiangsu Auditory Engineering Research Center, The Second College of Clinical Medicine, Xuzhou Medical University, Xuzhou, ChinaENT Department, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, ChinaThe First College of Clinical Medicine, Xuzhou Medical University, Xuzhou, ChinaJiangsu Auditory Engineering Research Center, The Second College of Clinical Medicine, Xuzhou Medical University, Xuzhou, ChinaENT Department, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, ChinaThe First College of Clinical Medicine, Xuzhou Medical University, Xuzhou, ChinaBackgroundInner ear disorders, such as EH, commonly lead to hearing loss and vestibular dysfunction. EH is particularly prevalent in various inner ear diseases, including Meniere’s disease. We aimed to evaluate the effects of EH on WAI and OAEs.ObjectiveThis study explores the potential of wideband acoustic immittance (WAI) and otoacoustic emissions (OAEs) for the early detection of changes in acoustic transmission associated with vasopressin-induced endolymphatic hydrops (EH) in a guinea pig model.MethodsWe induced EH in guinea pigs via daily intraperitoneal injections of arginine vasopressin over 14 consecutive days. Auditory function was assessed using Auditory Brainstem Responses (ABR), while changes in sound energy transmission were measured using WAI and Distortion Products Otoacoustic Emissions (DPOAE).ResultsIncreased ABR thresholds in EH models were statistically significant (p < 0.05). After 14 days of EH induction, absorbance at 1 kHz significantly increased, whereas it significantly decreased at 4 kHz and 6 kHz (p < 0.05). DPOAE measures, both magnitude and phase, showed no significant changes (p > 0.05).ConclusionWAI demonstrates greater sensitivity than DPOAE in the early detection of acoustic transmission alterations in EH models, suggesting its utility as a diagnostic tool in early-stage inner ear disorders.https://www.frontiersin.org/articles/10.3389/fneur.2025.1444928/fullwideband acoustic immittanceendolymphatic hydropsABRDPOAEguinea pigs |
| spellingShingle | Huan Lin Xuanyi Li Huiying Zhang Yi Mu Xi Wang Naveena Konduru Renlong Ji Wen Liu Wen Liu Wen Liu Zhao Fei Wen Jiang Wen Jiang Wen Jiang Yuehua Qiao Yuehua Qiao Yuehua Qiao The impact of endolymphatic hydrops on wideband acoustic immittance and otoacoustic emissions in guinea pigs Frontiers in Neurology wideband acoustic immittance endolymphatic hydrops ABR DPOAE guinea pigs |
| title | The impact of endolymphatic hydrops on wideband acoustic immittance and otoacoustic emissions in guinea pigs |
| title_full | The impact of endolymphatic hydrops on wideband acoustic immittance and otoacoustic emissions in guinea pigs |
| title_fullStr | The impact of endolymphatic hydrops on wideband acoustic immittance and otoacoustic emissions in guinea pigs |
| title_full_unstemmed | The impact of endolymphatic hydrops on wideband acoustic immittance and otoacoustic emissions in guinea pigs |
| title_short | The impact of endolymphatic hydrops on wideband acoustic immittance and otoacoustic emissions in guinea pigs |
| title_sort | impact of endolymphatic hydrops on wideband acoustic immittance and otoacoustic emissions in guinea pigs |
| topic | wideband acoustic immittance endolymphatic hydrops ABR DPOAE guinea pigs |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1444928/full |
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